About the book
The objective of the proposed book is to give a multi-perspective view on role of autophagy in injury, infection and cancer diseases. The book chapters aim to elucidate autophagy pathways in sustaining the host defense mechanisms, adaptive homeostasis as well as in remodeling and regeneration events that are essential for recuperation of the affected tissues. A specific subject for discussion will be up-regulation and/or impairment of autophagy and crinophagy in phagocytes/granulocytes and adult stem cells.
The cell/tissue responses to acute stress, trauma/injury or pathogens are mediated by expression and release of plethora of paracrine and endocrine effectors including DAMPs, PAMPs and inflammatory cytokines, chemokines, defensins, and reactive intermediate species. These effectors drive the integrative interactome constituted by hubs of the acute phase response modules, the inflammatory response modules, the module of the adaptive homeostatic response in the damaged parenchymal cells, vascular cells, immunocompetent cells and emerging stem cells. Among these defense mechanisms is autophagy – the lysosomal pathway for processing of compromised cell constituents and/or bacterial and viral pathogens. In this light, explication of the role of autophagy in cellular pathology may arouse R&D of new modalities for management of devastating diseases such as injury, acute infections or cancer.