Open access peer-reviewed Edited Volume

Autophagy in Injury, Infection and Cancer Diseases

Nikolai Gorbunov

Uniformed Services University of the Health Sciences


Autophagy-related Genes Autophagy-related Proteins Organelle Network Signaling Mechanisms and Modulators Cell Damage Tissue Damage PAMP and DAMP Inflammasome Autophagy Evasion Cancer Stem Cells Cancer Target Therapy Disease

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About the book

The objective of the proposed book is to give a multi-perspective view on role of autophagy in injury, infection and cancer diseases. The book chapters aim to elucidate autophagy pathways in sustaining the host defense mechanisms, adaptive homeostasis as well as in remodeling and regeneration events that are essential for recuperation of the affected tissues. A specific subject for discussion will be up-regulation and/or impairment of autophagy and crinophagy in phagocytes/granulocytes and adult stem cells.

The cell/tissue responses to acute stress, trauma/injury or pathogens are mediated by expression and release of plethora of paracrine and endocrine effectors including DAMPs, PAMPs and inflammatory cytokines, chemokines, defensins, and reactive intermediate species. These effectors drive the integrative interactome constituted by hubs of the acute phase response modules, the inflammatory response modules, the module of the adaptive homeostatic response in the damaged parenchymal cells, vascular cells, immunocompetent cells and emerging stem cells. Among these defense mechanisms is autophagy – the lysosomal pathway for processing of compromised cell constituents and/or bacterial and viral pathogens. In this light, explication of the role of autophagy in cellular pathology may arouse R&D of new modalities for management of devastating diseases such as injury, acute infections or cancer.

Publishing process

Book initiated and editor appointed

Date completed: September 23rd 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 13th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 2nd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 1st 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Nikolai Gorbunov

Uniformed Services University of the Health Sciences

Dr. Gorbunov obtained his Ph.D. degree in Biology from the Russian Academy Sciences. Then, he was a recipient of the NRC NAS ( and the Department of Energy fellowship awards to pursue postdoctoral training in translational science at the University of Pittsburgh and the Pacific Northwest National Laboratory ( Washington, USA). His translational research area has encompassed molecular pathology of trauma and countermeasures against acute radiation injury that was explored at the Walter Reed Army Institute of Research ( and the Uniformed Services University of the Health Sciences. His research interests are the disease-specific mechanisms driving alterations and defense responses in organelles, cells and tissues constituting biological barriers. With this perspective, the main objectives of his research are : i) to define the key components and pathways which regulate adaptive homeostasis and sustain intrinsic resistance to the harmful exposures and mediate recovery from the produced stress, cytotoxicity and damage; and (ii) to employ the acquired knowledge for advancement of injury-specific therapeutic modalities.

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Book chapters authored 2

Books edited 2

Introducing your Author Service Manager

Ms. Sandra Maljavac

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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