Open access peer-reviewed Edited Volume

Drug Metabolism

Katherine Dunnington

Celerion (United States)

Dr. Dunnington holds an interdisciplinary Ph.D. from the University of Missouri-Kansas City, she previously worked in MDS Pharma Services Lincoln, Nebraska, Principal Medical Writer PRA International Lenexa, KS and Pharmacist Hen House Pharmacy Gladstone, Missouri. Currently, she is a Senior Principal Scientist in the Data Management and Biometrics department at Celerion, USA.

Covering

Radio-labeled Profiling Mass Balance Oxidation Reduction Animal Model Hepatic Impaired Polymorphism Pharmacogenetics Immunogenicity Esterases Hepatocytes Liver Microsomes

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About the book

As scientists and health professionals, information regarding the metabolism of a given drug is a key aspect to its development, regulatory approval, and eventual use in patients. The sciences of drug metabolism are advancing rapidly; the objective of this book is to provide a multidisciplinary presentation regarding related topics that range from introduction of current best practices in clinical research to recent technical advancements. The determination of a drug's metabolic fate, the enzymatic pathways involved, the pharmacology of metabolites produced, the impacts of drug-drug or drug-disease interactions, slowly evolves during the non-clinical and pre-clinical development. Contributions to this project will provide the reader with a better understanding of the vast amounts of emerging information even outside his or her area of expertise. Comprehending the methods and science involved in determining the metabolic pathway and its implications will allow scientists and health professionals to interact on a new level and allow improved application of drug metabolism information provided in drug labeling and literature.

Publishing process

Book initiated and editor appointed

Date completed: September 18th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 15th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 5th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 4th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Katherine Dunnington

Celerion (United States)

Dr. Katherine "Shelly" Dunnington resides and works in the Midwest United States in the state of Kansas. She is a pharmacokineticst with training in pharmaceutical science and cellular/molecular biology, and originally was a practicing pharmacist both in hospital and retail settings. She is currently a Senior Principal Scientist in the Data Management and Biometrics department at Celerion, a pharmaceutical contract research organization. With 21 years in contract research, Dr. Dunnington has many roles in her current position, including training/mentoring scientists; consulting on clinical study design and conduct; analysis, interpretation, and reporting of clinical PK/PD and cardiac safety data, and software validation. Dr. Dunnington holds both a bachelor's of science degree in pharmacy, as well as an interdisciplinary Ph.D. from the University of Missouri-Kansas City.

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