Open access peer-reviewed Edited Volume

Hemophilia - Recent Advances and Future Perspectives

Cees Smit Sibinga

University of Groningen

Prof. Cees Th. Smit Sibinga is the founder of the European Society for Haemapheresis and co-founder of the World Apheresis Association. He is a long-term member of the WHO Expert Advisory Panel on Blood Transfusion Medicine. Prof. Smit Sibinga has written and edited over 35 books, published over 300 peer-reviewed articles and chapters.


Hemophilia A Hemophilia B Hemophilia C vWD Antenatal Counselling Gene Mapping Education Molecular Biology Genetics Classification Specification Cryoprecipitate Plasma-Derived Concentrates Recombinant Products Gene Therapy Musculoskeletal Access Affordability Source Material Cryoprecipitate Fractionation Socio-Economics Safety Efficacy Environment Education Social Acceptance Integration Genetic Engineering

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About the book

Over the past few decades a broad scala of developments took place advancing diagnostic tools, treatment and social life of patients suffering from inherited deficiencies of Factor VIII, Factor IX, Factor XI and von Willebrand factor. However, these advances are not universally accessible, applicable and affordable.

A large proportion of the global population lives in the less privileges part of the world and suffers from poor economics. Gene therapy might be a solution to avoid life long dependency on plasma derived clotting factors and inherently related risks e.g. infections and immune defined complications. Although currently gene therapy is expensive, it seems a promising investment because lifelong no more supplement therapy will be needed and patient will be able to contribute to society and economy in a normal way!

The book will provide information on these advances but also on the future perspectives with an emphasis on the diagnostic and treatment possibilities in poor economics in line with the 2012 UN Universal Health Coverage programme and the WHO Model List of Essential Medicines.

Publishing process

Book initiated and editor appointed

Date completed: July 3rd 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: September 22nd 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: December 11th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: February 9th 2021

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About the editor

Cees Smit Sibinga

University of Groningen

Prof. Cees Th. Smit Sibinga MD, PhD, FRCP Edin, FRCPath Cees Th. Smit Sibinga is a University of Groningen graduate, clinical haematologist and specialist of Transfusion Medicine. He is special professor of International Development of Transfusion Medicine at the University Medical Centre Groningen. He has been involved in the development of Transfusion Medicine and quality systems and management for economically restricted countries since 1980 through his work with the World Health Organization (WHO), the World Federation of Haemophilia (WFH) and the International Consortium for Blood Safety. For 25 years he has served as the Managing Director of Sanquin Division Blood Bank Noord Nederland in Groningen, the Netherlands. Since 1993 the Blood Bank did incorporate the WHO Collaborating Centre for Blood Transfusion and the WFH International Hemophilia Training Centre in Groningen. In 2001 the Blood Bank became the first Collaborating Centre of the International Consortium for Blood Safety (ICBS). Cees Smit Sibinga is now emeritus professor, but still deeply involved in the development of transfusion medicine through WHO, AABB (Global Transfusion Forum) and ISBT (Working Party on Global Blood Safety) and continues actively his academic health sciences oriented research and publications, and tertiary education in the developing part of the world. Quality Management Cees Smit Sibinga is the Founder of the Dutch Blood Bank Inspection and Accreditation Program and Haemovigilance System. His blood bank was the first non-American civilian blood centre accredited by the AABB in 1981. Since then he served the AABB inspection and accreditation program as a lead inspector/auditor till 2004. He also is the founder, first Director and Manager Operations of the Consulting Services* of the Sanquin Blood Supply Foundation and of the Academic Institute for International Development of Transfusion Medicine (IDTM)** at the University of Groningen in the Netherlands. He served (2000-2004) as the regional coordinator to the global WHO Quality Management Project for the Europe region. In addition, Cees Smit Sibinga has also been the first Vice President and Director of the AABB Consulting Services Division providing quality and process improvement solutions to Transfusion Medicine and related biological therapies worldwide, to which he now serves as the Senior Medical Advisor. * created in 2001 and ISO 9001:2000 certified since December 2004 ** created in 2001, registered under Dutch law as a Foundation since 2004 and ISO 9001:2000 certified since June 2007 Science and Education Cees Smit Sibinga has organized 28 international symposia on Transfusion Medicine in Groningen, published over 250 peer reviewed scientific articles and chapters in books, and edited over 30 books. He was the chairman of the organizing committee of the 1986 12th International Scientific Meeting Society for Low Temperature Biology in Groningen, the 1990 3rd WAA congress and vice-chairman of the 1994 International Congress of ISBT in Amsterdam. Cees Smit Sibinga has served ISBT in numerous working parties and committees (e.g. Socio-economic, Education, Publications, etc) and served as the Editor in Chief of Transfusion Today from 1992 till 2004. Cees Smit Sibinga is the founder of the European Society for Haemapheresis (EFSH) and a co-founder of the World Apheresis Association (WAA) and served both organizations as a President. Cees Smit Sibinga is the founder of the Academic Institute for International Development of Transfusion Medicine (IDTM) at UMCG, Groningen focused on restricted economy countries. This unique institute provides a post-academic Master course in Management of Transfusion Medicine (MMTM). He has edited over 35 books on Transfusion Medicine, published over 350 peer reviewed articles and 40 chapters in books and presented countless posters and orals at numerous international professional congresses and meetings of which the abstracts were published. International Consulting Since 1980 he has been increasingly involved in international short term consulting missions and medium and long term projects focused on the development of Transfusion Medicine in economically restricted countries in Asia, Eastern Europe, Africa, Western Pacific and the Middle East. Many of these missions and projects were undertaken and completed on behalf of WHO and/or on a specific request of country Ministries of Health. Biodata - Born 17-06-1939, Makassar, Indonesia Marital status married, 4 children, 8 grandchildren Education 1965, MD at University of Groningen 1971, Clinical Haematologist, University Medical Center, Groningen 1972, PhD University of Groningen 1992, FRCP Transfusion Medicine, Edinburgh, Scotland 1995, FRCPath Transfusion Medicine, London, UK

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