Open access peer-reviewed Edited Volume


Manash K. Paul

University of California Los Angeles

Successful Principal Investigator with demonstrated expertise in lung stem cell and lung cancer research. Lead teams and manage projects with a decisive, knowledgeable, and forward-thinking approach. Experienced teacher and multi-talented Investigator with experience in basic and translational research.


Adult Stem Cell Organoid Bioengineering Pharmacology Personalized Medicine Tissue Regeneration 3D Printing Transplantation Rare Disease Cancer Brain Organoids Liver Organoids

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About the book

Organoid technology is an interdisciplinary technique that uses stem cells' self-renewal and multi-differentiation abilities to self-organize into three-dimensional (3D) tissue-like structures termed organoids. Multiple tissue types, including the kidney, brain, lung, intestine, stomach, breast, and liver, have thrived in organoid culture. The potential for fundamental and translational research in cultivating organ-specific tissue organoids and disease modeling to mimic the physiology and intricacy of a tissue-specific disease is enormous. Given the disparities between animal models and human disease pathology, a paradigm shift toward the utilization of a 3D human organoid platform may aid in better understanding the human component of disease progression. The Organoids system offers insights into the human disease development process, signal interactions, cell-cell interactions, potential therapeutic targets, and drug screening and discovery. Genome editing, hybrid culture systems, biobank creation, and single-cell sequencing are examples of cutting-edge technologies that may help create more physiologically realistic human illness models, which can change drug discovery. The use of a person's own stem cells for customized disease modeling, organoid transplantation, and drug screening for precision treatment has become easier because of advances in biobanking.

Publishing process

Book initiated and editor appointed

Date completed: October 20th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: February 21st 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 12th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: July 11th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Manash K. Paul

University of California Los Angeles

Manash K. Paul, Ph.D., MRSB is currently working as an Assistant Project Scientist at the Department of Pulmonary and Critical Care Medicine, University of California, USA. His research area is lung stem cells and cancer, the leading cause of cancer death, and metastatic disease that is overwhelmingly the predominant cause of death. His studies deciphered that exosomes derived from highly motile premalignant cells can transfer metastatic phenotypes to neighboring healthy cells via paracrine signaling. While exosomes are known to serve as functional mediators in cell interaction leading to cancer metastasis, this will be the first comprehensive study to fully characterize the mechanisms underlying these events in the context of pulmonary premalignant migration, as well as in the context of metastatic cells from malignant pleural effusions using a microfluidic chip-based migration/ metastasis assay. Dr. Paul is the recipient of many awards that include the prestigious UCLA Vice Chancellor’s Award and was nominated for Paul Boyer’s award. Dr Paul is a member of multiple editorial boards and he has one registered patent. He has edited 2 books and authored/co-authored 44 journal papers, 7 book chapters, and 48 abstracts. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE). He is also a member of many esteemed societies including the Royal Society of Biology (MRCB), American Association for Cancer Research (AACR), International Society for Stem Cell Research (ISSCR), American Chemical Society (ACS), European Cancer Association (ECA), American Association of Indian Scientists in Cancer Research (AAISCR), International Society of Biotechnology (ISBT), Biotech Research Society (BRI) and Indian Associations of Teachers in Biological Sciences (IATBS).

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Book chapters authored 2

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Introducing your Author Service Manager

Mr. Josip Knapic

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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