Open access peer-reviewed Edited Volume

Leukemia - From Biology to Diagnosis and Treatment

Margarita Guenova

Laboratory of Haematopathology and Immunology, National Specialized Hospital for Active Treatment of Haematological Diseases

Head of the national reference diagnostic laboratory for malignant blood diseases, professor of hematology, member of national and international medical societies, and author/co-author of research papers related to leukemia.

Co-editor:

Gueorgui Balatzenko

Laboratory of Cytogenetics and Molecular Biology at the National Specialised Hospital for Active Treatment of Haematological Diseases

Dr.Balatzenko is a Professor of Hematology and Blood Transfusion at the Laboratory of Cytogenetics and Molecular Biology at the National Specialised Hospital for Active Treatment of Haematological Diseases, Sofia, Bulgaria. He has authored and co-authored many articles in peer-reviewed journals and book chapters. He is a member of several professional societies, such as the Bulgarian Society of Hematology, the Bulgarian Society of Genetics, and the European Hematology Association; a life member of the UICC.

Covering

Leukemogenesis Diagnosis Target Therapies Minimal Residual Disease COVID-19 Molecular Biology Mechanisms of Resistance and Disease Progression Treatment-Free Remission New Drugs in Development Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Acute Myeloid Leukemia Biomarkers

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About the book

Novel technological, molecular, and immunologic approaches are rapidly creating novel insights into the biology and therapeutic perspectives of leukemias. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options of leukemias requires frequent updating of this topic.
The primary objective of this book is to provide the specialists involved in the clinical management and experimental research of acute and chronic leukemias updates on the theoretical aspects as well as state-of-the-art diagnostic and clinical management of acute and chronic leukemias.

The book is intended to cover a broad spectrum of leukemia-related topics such as:
-novel and still evolving insights into the biology and diagnosis and how these result in new drug approvals and new therapeutic options with a focus on molecular and immunotherapeutic targeted therapeutics,
- the molecular and functional features of leukemic stem cells and their interaction with the microenvironment,
- preleukemic hematopoiesis and clonal diversity,
- new standard treatment algorithms,
- mechanisms of resistance and disease progression
- diagnosis and management of rare acute leukemia subtypes,
- Covid-19 aspects in specific leukemia categories,
- real-world data
- new drugs in development

Publishing process

Book initiated and editor appointed

Date completed: April 5th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: July 2nd 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: September 20th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: November 19th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Margarita Guenova

Laboratory of Haematopathology and Immunology, National Specialized Hospital for Active Treatment of Haematological Diseases

Professor Dr. Margarita Guenova received her medical training at the Medical University of Sofia and her PhD degree at the National Center of Haematology in 2000. She is employed as Head of the Laboratory of Haematopathology and Immunology and Professor of Hematology and Blood Transfusion at the National Specialised Hospital for Active Treatment of Haematological Diseases, Sofia, Bulgaria, teaching both undergraduate and graduate studies at the Sofia Medical University. She specializes in the field of leukemia and lymphoma diagnostics. In regard to her scientific interests, she worked on the elucidation of critical mechanisms of leukemia pathogenesis and progression, investigation of clinically relevant biomarkers and potential targets for therapy in leukemias and lymphomas, characterization of leukemic stem cell populations, minimal residual disease, and implementation of a multifaceted approach in oncohematology. Dr. Guenova has authored and coauthored many abstracts, articles in peer-reviewed journals, and book chapters. She serves on several editorial boards and is the Past-president of the Bulgarian Society of Hematology as well as a member of several professional societies, such as the Bulgarian Society of Pathology, the Bulgarian Association of Clinical Immunology, the European Hematology Association, the European Association of Haematopathology, and the International Society of Haematology.

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Book chapters authored 3

Books edited 3

Introducing your Author Service Manager

Ms. Ana Cink

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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