About the book
Polycystic ovary syndrome (PCOS) is a major health problem with a heterogeneous hormone-imbalance disorder that occurs in reproductive-aged women worldwide, which is characterized by hyperandrogenism, ovulatory process dysfunction and polycystic ovaries. PCOS is affected by various factors and there are no unique diagnostic criteria in different regions, due to the heterogeneity of clinical manifestations and endocrine system changes of PCOS. Therefore, it is often difficult to accurately diagnose women with PCOS, as the signs and symptoms of PCOS can vary among individuals. Although PCOS is usually diagnosed during the early reproductive years, but the precise pathogenesis of PCOS remains unclear. An increasing number of studies have demonstrated that the insulin signaling pathway has an important role in the pathophysiology of PCOS, including phosphatidylinositol 3-kinase and protein kinase B signaling, which is critically implicated in insulin resistance, androgen secretion, obesity and follicular development. PCOS manifests as defective ovarian steroid biosynthesis and hyperandrogenemia, and 50~70% of women with PCOS exhibit insulin resistance and are hyperinsulinemic, indicating that insulin resistance and hyperinsulinism may have an important role in the pathophysiology of PCOS.
This book will intend to provide the reader with a comprehensive overview of the current state-of-the-art in PCOS researches and to benefit the population of women with PCOS. At last, It is my hope that this book will be meaningful to the clinicians who care for women with PCOS and to the researchers who investigate the complexities of this disorder disease.