About the book
Ulcerative colitis is an idiopathic disorder of the colonic mucosa without precise cause of gut inflammation. Its prevalence is higher than the prevalence of Crohn disease. Incidence is higher in North America and northern Europe, but it has increased in countries that have adopted a western lifestyle.
Genetically susceptible individuals seem to have a dysregulated mucosal immune response to commensal gut flora, but environmental factors might trigger the disease onset.
The clinical course of ulcerative colitis is characterized by alternating periods of remission and relapse, with extension of colonic disease in time, but with similar mortality to the general population.
The treatment is complex, targeting the induction of response and remission, followed by maintenance of remission, and surgery in case of emergencies, refractoriness or intolerance to long-term maintenance treatments , or dysplasia or colorectal cancer.
This book intends to provide the reader with a comprehensive overview of the current state-of-the-art in patient’s epidemiology, physiopathology, diagnosis, complications and therapy, focusing on the most important evidence-based developments in this critically important area.