Open access peer-reviewed Edited Volume

Iatrogenic Diseases - The Role of Drugs

Oreste Capelli

Local Health Authority of Modena


Maria Isabella Bonacini

University Hospitals Plymouth NHS Trust


Drug Efficacy Cardiovascular Drugs Preventive Therapy Drug Safety Chronic Conditions Drugs Interactions Prescribing Cascade Deprescribing Algorithm Holistic Care Proton Pump Inhibitors Palliative Care Limited Life Expectancy

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About the book

The increase in life expectancy leads to an increase in the number and duration of chronic diseases, affecting the majority of people over 60. Consequently, the number of drugs that each patient takes for year increases, both for therapeutic and preventative purposes. Unfortunately, little is known about the damage that politherapies can cause in individual organisms, and when the drugs have been taken for a long time (i.e for decreased absorption or a modified metabolism).
Another area of uncertainty is the potential effect following the suspension/ interruption of some chronic therapies in defined clinical situations.

The purpose of this text is to highlight both the positive and negative aspects of polytherapy in elderly subjects and when it should be necessary to take into consideration the regulated suspension (deprescribing) of one or more drugs. In particular, it would be important reducing or avoiding the prevalence of negative effects, which can even accelerate cognitive or physical decay, leading sometimes to premature death.

Publishing process

Book initiated and editor appointed

Date completed: June 15th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: July 6th 2020

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: September 4th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: November 23rd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: January 22nd 2021

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About the editor

Oreste Capelli

Local Health Authority of Modena

Dr. Oreste Capelli graduated in Medicine and Surgery with honors in 1981, specialized in 1985 in Pneumology and in 1992 in Internal Medicine. In 2003 he obtained a master's degree in Evidence-Based Medicine and Research Methodology, in 2010 a three-year degree in Systemic Counseling and in 2015 the master's degree in Direction and Management of Health Services. He worked as Hospital Pulmonologist from 1985 to 1990, then as a General Practitioner until 2003. From 2004 to 2019 he held various positions in Public Health, as a Clinical Methodologist and Researcher in the Organization of care pathways for Chronic Diseases. From 2012 to 2014 he was the referent for the care pathways for chronic diseases of the Emilia Romagna Region and from 2015 to 2019 he was Director of the Clinical Governance and Medical Library of the Local Health Authority of Modena. From 2017 to 2019 he was a member of the local Research Ethics Committee. Dr. Capelli has held hundreds of seminars on the topics of EBHC, Clinical Governance, and Prescriptive Appropriateness. He is a co-author of numerous scientific articles, book chapters, and speeches at national and international conferences.

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Book chapters authored 7

Books edited 2

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