Open access peer-reviewed Edited Volume

Towards New Perspectives on Toxoplasma gondii

Saeed El-Ashram

Foshan University

Dr. El-Ashram's research focuses on apicomplexan parasites, such as Toxoplasma and Eimeria. He has more than 96 SCI publications, he acted as an academic editor, reviewer, and he holds several registered patents.

Co-editors:

Guillermo Téllez

University of Arkansas at Fayetteville

Researcher in enteric health, most notably probiotics and their relationship to nutrition and disease protection in poultry as well as the design of avian enteric inflammation models for the study of the impact of diet and microbiome on growth and development.

Firas Alali

University of Kerbala

My research focuses mainly on apicomplexan parasites, such as Toxoplasma Cryptosporidium, Eimeria, and minor on nematodes. Prof.Alali has more than 30 publications and he acts as a reviewer in many journals.

Covering

PCR Genotyping ELISA Cell Lines 2D Culture 3D Culture PRRs CD4 Responses CD8 Responses Behavior Manipulation Parasite Cysts Psychiatric Disorders

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About the book

Toxoplasma gondii is a heterogenous protozoan parasite found in virtually all animal species and billions of latently infected people worldwide. Toxoplasmosis may result in lifelong impairment or death in a human host with a weakened immune system, such as an unborn child or newborn, or an AIDS patient. T. gondii may be transferred by contact with cat feces. This was formerly thought to be the most common mode of infection in humans. Subsequent studies with mouse and Felidae models revealed that T. gondii bradyzoites inside intracellular cysts in muscle and brain tissue are considerably more infectious than the oocyst shape discharged in cat feces. This suggests that eating contaminated animal products may also have a significant influence on the world's high prevalence of toxoplasmosis infection. T. gondii immunity is a complicated process that involves both innate and adaptive immune responses. T. gondii has been utilized as a model system pathogen to research macrophage function, cell-mediated immunity, dendritic cells, and the gut-associated immune response. Parasitic manipulation of host behavior is often exploitative, as parasites seek rewards such as food, shelter, or use as a gateway to another host. T. gondii, for example, has been found to change rats' inherent aversion to cat scents, enhancing its chances of transmission. A rising body of research suggests a statistical link between persistent infection and neurological diseases that contribute to behavioral and psychological issues in healthy people. T. gondii has been linked to mental illnesses like schizophrenia and bipolar disorder.

This book is the culmination of six chapters. We hope that the chapters will serve as concise summaries of the present status of the research on T. gondii, allowing for simple access to studies on it. The scientific community's active cooperation was vital in bringing this initiative to fruition. We anticipate that the finished result will be a valuable resource for academics interested in studying T. gondii or using it as a model eukaryotic pathogen.
 

Publishing process

Book initiated and editor appointed

Date completed: March 4th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: July 5th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: September 23rd 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: November 22nd 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Saeed El-Ashram

Foshan University

Dr. Saeed El-Ashram is a professor at Foshan University, China, and Kafrelsheikh University, Egypt, and a research professor at Zhaoqing Dahuanong Biology Medicine Co., Ltd., China. Dr. El-Ashram\'s research focuses on parasitic diseases. He has more than 100 journal publications to his credit. He is currently an academic editor and reviewer and holds several registered patents. The primary focus of his research is to understand how the animal immune system recognizes and responds to parasitic infections with and/or without a microbial community. Some are the causative agents of significant diseases in humans, such as toxoplasmosis, cryptosporidiosis, alveolar echinococcosis, and fascioliasis. Others are a substantial financial burden to food producers because of the effects these parasites have on domestic animals, for example, coccidiosis and cryptosporidiosis (livestock and poultry).

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