Open access peer-reviewed Edited Volume


Vasil Georgiev

Bulgarian Academy of Science


Atanas Pavlov

Bulgarian Academy of Science


Phytochemistry Structure Elucidation Biodiversity Alkaloids Pharmacology Anesthetics Relaxant Narcotic Cytotoxic Acetylcholine Esterase Inhibitors Antimicrobial Activity Biotechnology Cell Culture Technology Synthetic Biology

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About the book

Alkaloids are secondary metabolites with a wide range of biological and pharmacological properties. These nitrogen-containing natural compounds are produced mainly by plants, but also could be found in some animals, insects, algae and marine organisms. Many alkaloids have been used in medicine for centuries, because of their anesthetics, relaxant, cytotoxic, neurotoxic, toxic, anti-microbial activities and anti-cancer activities. Recently, with the advance in alkaloids chemistry, many new structures have been discovered and thousands of synthetic and semisynthetic analogs have been produced. Nowadays, searching for novel drug candidates with improved therapeutic properties greatly increased the scientific attention to alkaloids chemistry, biochemistry and pharmacology. In parallel with the improved methods for isolation and purification from natural sources, various new biotechnological methods, based on plant cell culture technology, have been developed for sustainable production of some valuable and rare alkaloids. This book intends to provide the reader with a comprehensive overview of the current state-of-the-art in alkaloids research, including, but not limited to chemistry, biochemistry, biosynthesis, synthesis and modifications, analytical techniques, pharmacology, biological and physiological activities, bioavailability, and medicinal application of natural, synthetic and semi-synthetic structures.

Publishing process

Book initiated and editor appointed

Date completed: October 3rd 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 24th 2019

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: December 23rd 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 12th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 11th 2020

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About the editor

Vasil Georgiev

Bulgarian Academy of Science

Dr. Vasil Georgiev obtained his Ph.D. degree at the Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, in 2009. He is an expert on bioprocess engineering and secondary metabolite production by plant cells, tissue and organ cultures, functional genomics, metabolite profiling, development, and improvement of a plant in vitro production platforms. In 2011, he was awarded by the Bulgarian Academy of Sciences with the 'Prof. Marin Drinov” prize for outstanding research in biological sciences. Dr. Georgiev did postdoctoral research at Florida A&M University, Tallahassee, FL, USA (2012–2016), and he was a faculty in the Department of Organic Chemistry at the University of Food Technologies, Plovdiv, Bulgaria (2016-2019). Since 2016, Dr. Georgiev is an Associate Professor in the Laboratory of Applied Biotechnology at the Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences.

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