Open access peer-reviewed Edited Volume

Ion Channel Dysfunction in Disease

Saverio Gentile

University of Illinois at Chicago


Reprogramming Metabolism Cell Death Evasion Inflammation Mechanisms of Immune Response Aerobic Glycolisis Autophagy Oxidative Stress Neurodegeneration Mitochondrial Function Cardioprotection Diabetes Osteoporosis

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About the book

Ion channels belong to a large family of proteins that play important key roles in biology. Traditionally, the physiological and/or pathological role of ion channels have been vastly studied in neurons and myocytes. Nevertheless, recently, numerous studies have demonstrated that ion channels can control a variety of ion channels play fundamental role in a variety of cellular events that are involved in cancer, metabolism, aging and metabolic diseases. For example, ion channels have emerged to contribute to several hallmarks of cancer including sustaining proliferative signaling or evasion to cell death, therefore becoming a potential target class for cancer treatment. Also, new research has demonstrated that ion channels can control the immune response as well as cell metabolism indicating that these proteins are fundamental factors for life homeostasis. In contrast, dysregulation of ion channels plays a major role in disease as well as in the aging process indicating that manipulation of ion channel activity is a formidable tool to regulate physiologic and pathologic events.

Remarkably, drug discovery focused on ion channels has generated an abundance of medicines of critical importance in the pharmacopeia for treating human diseases. This book focuses on the most important evidence-based developments in disease research and intends to provide the reader with a comprehensive overview of the current state-of-the-art in the new field of ion channel in disease. 

Publishing process

Book initiated and editor appointed

Date completed: September 23rd 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 13th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 2nd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 1st 2020

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About the editor

Saverio Gentile

University of Illinois at Chicago

Dr. Gentile obtained his Ph.D. in neurobiology and worked as post-doctoral fellow at the National Institute of Environmental Sciences NIEHS/NIH and at Duke University in which he developed expertise in ion channels. Currently, he is an Assistant professor in the Department of Medicine at the University of Illinois in Chicago. Dr. Gentile’s research focus is on the role of ion channels in cancer biology. His research has brought to light new function of potassium channel in several aspects of cancer including proliferation, senescence, metabolism and metastasis. In collaboration with several clinicians, Dr. Gentile and his team are focusing on developing an anticancer pharmacological approach by targeting potassium channels in breast and ovarian cancer.

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