About the book
Ion channels belong to a large family of proteins that play important key roles in biology. Traditionally, the physiological and/or pathological role of ion channels have been vastly studied in neurons and myocytes. Nevertheless, recently, numerous studies have demonstrated that ion channels can control a variety of ion channels play fundamental role in a variety of cellular events that are involved in cancer, metabolism, aging and metabolic diseases. For example, ion channels have emerged to contribute to several hallmarks of cancer including sustaining proliferative signaling or evasion to cell death, therefore becoming a potential target class for cancer treatment. Also, new research has demonstrated that ion channels can control the immune response as well as cell metabolism indicating that these proteins are fundamental factors for life homeostasis. In contrast, dysregulation of ion channels plays a major role in disease as well as in the aging process indicating that manipulation of ion channel activity is a formidable tool to regulate physiologic and pathologic events.
Remarkably, drug discovery focused on ion channels has generated an abundance of medicines of critical importance in the pharmacopeia for treating human diseases. This book focuses on the most important evidence-based developments in disease research and intends to provide the reader with a comprehensive overview of the current state-of-the-art in the new field of ion channel in disease.