Open access peer-reviewed Edited Volume

Post-Translational Modifications in Cellular Functions and Diseases

Shibo Ying

Hangzhou Medical College

A young biological researcher in post-translational modifications with extensive overseas experience, the awardee of a Japanese government scholarship, a former research fellow of the German Cancer Research Center, Chinese Society for Cell Biology permanent member and holder of two grants from NSFC.

Covering

Enzyme Activity Intrinsic Disorder Protein Structure Transcription Factor Cell Apoptosis Cell Proliferation Cellular Signal Transduction Gene Regulation Carcinogenesis Diagnostic Marker Prognostic Marker Therapeutic Target

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About the book

Post-translational modification (PTM) is an elaborate process that occurs on a protein after its translation by ribosomes is complete. PTMs of proteins are crucial because they may alter the physical and chemical properties, folding, stability, activity, localization, molecular interaction and consequently the functions of the targets. PTMs are mostly catalyzed by special enzymes that recognize specific target sequences in specific proteins. To date, more than 400 different types of PTMs have been identified, including phosphorylation, methylation SUMOylation, acetylation, ubiquitination, glycosylation, hydroxylation, ADP-ribosylation, palmitoylation, citrullination and other novel protein-bound amino acid modifications. PTMs can be mainly grouped into reversible and irreversible categories according to their stability or transience. Most reversible PTMs are usually associated with cellular signal transduction and gene regulation, which are utilized as a switch to control the state of cells being the resting or proliferating in normal cells. Some irreversible PTMs are also involved in cell apoptosis, cell cycle and cell differentiation, which may lead to abnormal pathogenesis or tumorigenesis. There has been an increasing appreciation for the roles of PTMs in a wide variety of cellular functions and diseases.

This book intends to provide the reader with an overview of the current state-of-the-art in this research field, which focuses on the recent advances, new findings and perspectives in cellular functions and their clinical applications in human diseases.
 

Publishing process

Book initiated and editor appointed

Date completed: October 7th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: November 4th 2020

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Approved chapters written in full and submitted

Deadline for full chapters: January 3rd 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 24th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 23rd 2021

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About the editor

Shibo Ying

Hangzhou Medical College

Dr. Shibo Ying is an associate professor in Hangzhou Medical College (China). He graduated and obtained his Ph.D. in Applied Life Sciences from Tokyo University of Agriculture and Technology (Japan) in 2011. He was awarded Japanese government scholarship and he visited University of California at Davis (UCD) as an exchange student in 2010. After his graduation, he became a research fellow at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg (Germany). Dr. Ying acts as a reviewer of many scientific journals and has authored or co-authored over 25 scientific publications. His research interests include molecular mechanisms of post-translational modification, such as SUMOylation, citrullination, and their clinical relevance in human diseases.

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