Open access peer-reviewed Edited Volume

Ovarian Cancer - Updates in Tumour Biology and Therapeutics

Gwo Yaw Ho

Monash University

A specialist in treating women with breast and gynecologic cancer, Dr. Gwo Yaw Ho is a senior medical oncologist at Monash Health. He completed his Ph.D. at the Walter and Eliza Hall (WEHI) Institute of Medical Research whilst practicing as a medical oncologist at the Peter MacCallum Cancer Centre and Royal Women’s Hospital, Melbourne.


Kate Webber

Monash University

Dr. Kate Weber is a medical oncologist with a keen interest in gynaecological oncology, cancer survivorship and clinical trials. Research arising from her PhD has been presented at scientific meetings for the American Society of Clinical Oncology, International Gynaecological Cancer Society and European Society of Gynaecological Oncology. She is the co-chair of the Cancer Institute NSW eviQ Medical Oncology Reference Committee.


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About the book

Ovarian cancer (OC) is a heterogeneous disease composed of multiple distinct molecular and clinical subtypes. Women with OC, in particular high grade serous ovarian cancer (HGSOC), face a formidable challenge as fatal resistance to therapies commonly occurs within a few years of diagnosis. Improvement in our ability to target the underlying drivers and vulnerabilities of HGSOC is essential to develop effective treatments for women battling this disease. Despite a decline in age-adjusted incidence and cancer death for OC over the last 2 decades, these advancements and progress are less impressive compared to the breast, colorectal and prostate cancer outcomes. OC is one of only four cancer types that has a smaller decline in age-adjusted death rate compared to age-adjusted incidence rate. As the death rate has not reduced by more than the incidence rate, this suggests that the improvements and advancements in OC screening and treatment have only a modest impact in lowering OC death rate. To develop more effective treatments for HGSOC, an in-depth understanding of the early genetic events in HGSOC tumorigenesis is crucial.

This book will intend to provide the reader with a comprehensive overview of the genomic landscape of ovarian cancer and tumorigenesis, challenges in managing this cancer as well as an in-depth update in novel therapeutic approaches and pre-clinical models. The book will also address major key issues in ovarian cancer survivorship.

Publishing process

Book initiated and editor appointed

Date completed: September 9th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 7th 2020

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Approved chapters written in full and submitted

Deadline for full chapters: December 6th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 24th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 25th 2021

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About the editor

Gwo Yaw Ho

Monash University

Gwo Yaw Ho is a senior medical oncologist at Monash Health and he specialises in treating women with breast and gynaecologic cancer. He has an academic appointment with Monash University as a research fellow and was awarded the Monash University, School of Clinical Science Clinician-scientist Fellowship in 2019. He completed his PhD study in 2019 at the Walter and Eliza Hall (WEHI) Institute of Medical Research whilst practicing as a medical oncologist at the Peter MacCallum Cancer Centre and Royal Women’s Hospital, Melbourne. The focus of his research is a subset of high-grade ovarian cancer, including carcinosarcoma, with the poorest outcome which is associated with increased activity of the oncogenic MYCN pathway.

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