Open access peer-reviewed Edited Volume

Antiphospholipid Syndrome - Recent Advances in Basic and Clinical Aspects

Polona Žigon

University Medical Centre Ljubljana

A senior researcher at the University Medical Center Ljubljana investigating diagnostic aspects of systemic autoimmune diseases. A teaching assistant, Ph.D. student mentor, co-author of 31 original scientific articles published in peer-reviewed journals, six chapters, and one patent application.


Prothrombotic Antibodies Coagulopathy Exosomes Microvesicles Surface Protein Markers Antiphospholipid Antibodies Thrombosis Pregnancy Complications Inflammation Interferons Neutrophils COVID-19

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About the book

Antiphospholipid syndrome is a systemic autoimmune disease characterized by vascular thrombosis and/or pregnancy-related morbidity, accompanied by persistent positive antiphospholipid antibodies. It is considered the most common acquired form of thrombophilia worldwide. Obstetric antiphospholipid syndrome is a complex entity that can affect both the mother and the fetus throughout pregnancy with high morbidity. In the general population, the incidence of clinical manifestations relevant to antiphospholipid syndrome is high and could often be triggered by other underlying factors. Consequently, diagnosis of antiphospholipid syndrome is still mainly based on laboratory measurements of antiphospholipid antibodies. However, the available laboratory-based tests are hampered by technical limitations, and despite the many attempts to increase the specificity of laboratory criteria and establish consensus criteria for serology, a high number of patients are still diagnosed inaccurately. There is a need for novel, robust and reliable biomarkers, firstly to detect antiphospholipid syndrome and secondly to monitor the risk of recurrence over time.

This book provides essential insights into recent advances in molecular diagnostic approaches to antiphospholipid syndrome and new findings in the pathophysiology of antiphospholipid syndrome. In addition, recent discoveries about the thrombo-inflammatory nature of the disease are included, providing the reader with the necessary information to understand the complexity of the disease.

Publishing process

Book initiated and editor appointed

Date completed: October 7th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: November 4th 2020

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Approved chapters written in full and submitted

Deadline for full chapters: January 3rd 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 24th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 23rd 2021

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About the editor

Polona Žigon

University Medical Centre Ljubljana

Dr. Polona Žigon is a senior scientist at the Department of Rheumatology, University Medical Center Ljubljana and is teaching assistant at the Faculty of Mathematics Natural Sciences and Information Technologies, University of Primorska. She obtained MSc in Clinical Biochemistry in 2008 and PhD in Biomedicine in 2014 at the Faculty of Pharmacy, University of Ljubljana. During her post-graduate studies, she completed a 6-month research internship in the School of Medicine at the Hokkaido University Sapporo, Japan. She is a member of Slovene Chamber Laboratory Medicine, a working member of EMEUNET and a member of the Autoimmunity Network. Her research in the field of systemic autoimmune diseases resulted in more than 30 original scientific articles published in peer-reviewed journals, six chapters and one patent application.

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