About the book
Antiphospholipid syndrome is a systemic autoimmune disease characterized by vascular thrombosis and/or pregnancy-related morbidity, accompanied by persistent positive antiphospholipid antibodies. It is considered the most common acquired form of thrombophilia worldwide. Obstetric antiphospholipid syndrome is a complex entity that can affect both the mother and the fetus throughout pregnancy with high morbidity. In the general population, the incidence of clinical manifestations relevant to antiphospholipid syndrome is high and could often be triggered by other underlying factors. Consequently, diagnosis of antiphospholipid syndrome is still mainly based on laboratory measurements of antiphospholipid antibodies. However, the available laboratory-based tests are hampered by technical limitations, and despite the many attempts to increase the specificity of laboratory criteria and establish consensus criteria for serology, a high number of patients are still diagnosed inaccurately. There is a need for novel, robust and reliable biomarkers, firstly to detect antiphospholipid syndrome and secondly to monitor the risk of recurrence over time.
This book provides essential insights into recent advances in molecular diagnostic approaches to antiphospholipid syndrome and new findings in the pathophysiology of antiphospholipid syndrome. In addition, recent discoveries about the thrombo-inflammatory nature of the disease are included, providing the reader with the necessary information to understand the complexity of the disease.