Open access peer-reviewed Edited Volume

Mild Cognitive Impairment

Denis Larrivee

Loyola University Chicago


Amnestic MCI Non-amnestic MCI tau/beta amyloid ratios Lewy Body Dementia Enactment Coding memory impairment Montreal Cognitive Assessment white matter disruption object naming visual spatial processing prospective memory training

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About the book

Clinically identified in 1997, mild cognitive impairment (MCI) represents a stage of age related cognitive decline often described as midway between deficits incurred in normal aging and those associated with dementia. Diagnosis of MCI is notably correlated with a greatly increased risk in incidence of dementia, ranging from 5 to 10 fold higher than the 1 % incidence level in the general population; hence, it is significant as a prognosticator and research domain. Its relationship to the progression of dementia, however, is complex, with high rates of reversion as well as variability in symptomatic expression, time course, and outcome. In Petersen's algorithm, for example, amnestic MCI is tasked to Alzheimer's dementia, whereas non-amnestic MCI devolves to frontotemporal lobular dementia. MCI's clinically complex diagnosis is increasingly well resolved with unique phenomenal subgroups now distinguished in terms of the impairments associated with amnestic and non- amnestic cognitive features. Relating these to underlying neural correlates, which may evolve to more severely impaired states of AD or other forms of dementia, and those that do not so evolve, however, remains an open but increasingly tractable problem that holds promise for therapy aimed at mitigating cognitive decline. This book will incorporate insights from diagnostic and dementia studies, as well as findings from a growing range of potential therapies that include transcranial magnetic stimulation, neuroplasticity and cognitive exercise, and dietary and pharmaco supplements. For a rapidly growing population at risk, the book promises up to date insights into positive prognostication and therapeutic possibility of this unique state of cognitive impairment.

Publishing process

Book initiated and editor appointed

Date completed: August 19th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 8th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: January 27th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: March 27th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Denis Larrivee

Loyola University Chicago

Dr. Denis Larrivee is a visiting scholar at the Mind and Brain Institute, University of Navarra Medical School and Loyola University, Chicago, and has held professorships at Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University’s Medical School he received the Association for Research in Vision and Ophthalmology’s first place award for studies on photoreceptor degenerative and developmental mechanisms. He is the editor of a recently released text on brain computer interfacing with IntechOpen Publishing and an editorial board member of the journals Annals of Neurology and Neurological Sciences (USA) and EC Neurology (UK). An International Neuroethics Society expert he is the author of more than 75 papers and book chapters on such varied journals/venues as Neurology and Neurological Sciences (USA), Journal of Neuroscience, Journal of Religion and Mental Health, and IEEE Explore. In 2018 he was a finalist in the international Joseph Ratzinger Expanded Reason award.

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