Open access peer-reviewed Edited Volume

Regulation and Dysfunction of Apoptosis

Yusuf Tutar

University of Health Sciences

An eminent scientist in the molecular mechanism, appointed head of Biochemistry and Molecular Medicine Division of University of Health Sciences, editor of top journals, and holder of several awards and one registered patent.


Apoptosis Programmed Cell Death Granzyme Perforin Cell Cycle Proliferation Pathology of Apoptosis Mathematical Modelling System Modelling Assays of Apoptosis PARP-Caspase Inhibitors Clinical Applications

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About the book

Apoptosis or programmed cell death is an essential biochemical process that mediates cell turnover, immune system, embryonic development, and induced cell death. Malfunction in the apoptotic mechanism leads to various human diseases, including but not limited to neurodegenerative diseases, cancer, and immune disorders. Therefore, physiology and pathology of apoptosis are under intensive investigation to reveal therapeutic potential out of these correlations. Cell cycle machinery and signaling pathways are the focus of the biochemical process to understand cell cycle arrest and apoptosis control mechanism. Although most components of this energy-dependent pathway have been identified, physiology and pathology of the initiation as well as inhibitors-activators have been under investigation. Apoptotic machinery is an important part of health and disease and this book provides recent insights into novel research that may influence therapeutic interventions.

The first part of the book will spotlight signaling pathways, physiology, and pathology of the apoptosis, while the second part of the book will elaborate mathematical modeling of the apoptosis, instrumental assays, and clinical applications. The book will compile a comprehensive review of the current literature. Therefore, it will not be interesting only to early-career scientists, but also to the experienced researchers who want to link relevant research to their analysis.

Publishing process

Book initiated and editor appointed

Date completed: October 23rd 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: December 1st 2020

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: January 30th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: April 20th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: June 19th 2021

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About the editor

Yusuf Tutar

University of Health Sciences

Prof. Dr. Yusuf Tutar is the head of Biochemistry Division at the Faculty of Pharmacy, University of Health Sciences, Istanbul, Turkey. Dr. Tutar is also the coordinator of the Molecular Medicine Division at the same university. He obtained his MSc and Ph.D. degrees at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and National Institutes of Health (NIH/NIDDK), USA. Dr. Tutar’s research is mainly focused on biochemistry, biophysics, genetics, and molecular biology with a specialization in the fields of prion, drug design, cancer, protein structure-function, protein folding, microRNA, pseudogenes, molecular cancer, proteomics, genomics, and protein expression and characterization by spectroscopic and calorimetric methods.

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Book chapters authored 1

Books edited 3

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