About the book
Apoptosis or programmed cell death is an essential biochemical process that mediates cell turnover, immune system, embryonic development, and induced cell death. Malfunction in the apoptotic mechanism leads to various human diseases, including but not limited to neurodegenerative diseases, cancer, and immune disorders. Therefore, physiology and pathology of apoptosis are under intensive investigation to reveal therapeutic potential out of these correlations. Cell cycle machinery and signaling pathways are the focus of the biochemical process to understand cell cycle arrest and apoptosis control mechanism. Although most components of this energy-dependent pathway have been identified, physiology and pathology of the initiation as well as inhibitors-activators have been under investigation. Apoptotic machinery is an important part of health and disease and this book provides recent insights into novel research that may influence therapeutic interventions.
The first part of the book will spotlight signaling pathways, physiology, and pathology of the apoptosis, while the second part of the book will elaborate mathematical modeling of the apoptosis, instrumental assays, and clinical applications. The book will compile a comprehensive review of the current literature. Therefore, it will not be interesting only to early-career scientists, but also to the experienced researchers who want to link relevant research to their analysis.