About the book
Multifactorial heredity refers to the action of several genes, which interact with each other and together with environmental factors and determine a certain phenotype. These genes have a minor effect but their action adds up and creates the genetic predisposition.
Genetic predisposition is converted into a pathological phenotype only under the effect of environmental factors.
Multifactorial disorders are considered to be the most common features that affect people, such as diabetes, high blood pressure, coronary heart disease, and cancer, as well as some of the common isolated birth defects, including cleft lip or palate, neural tube defects, congenital heart disease, and clubfoot.
Multifactorial inheritance did not follow a simple Mendelian pattern. However, the recurrence risk of multifactorial disorders is higher in relatives of affected individuals than in the general population. The empirical risks of a multifactorial disorder are based on large population studies.
It is important to understand the multifactorial transmission model for proper genetic counseling and for avoiding environmental factors, a measure that could ensure the prophylaxis of these common diseases.
This book intends to provide valuable evidence-based information, a comprehensive overview of this complex pathology. The aim will be to highlight the importance of collaboration and multidisciplinary teams for multifactorial disease management in an easy-to-follow format.