About the book
Aromatase is an enzyme coded by the CYP19 gene located on chromosome 15q21. The enzyme catalyzes the production of estrogen from androgen (ie testosterone and androstenedione) in the form of estrone and 17β-estradiol. Aromatase is normally located in the endoplasmic reticulum of the cells in adrenal glands, ovaries, testes, placenta, fatty tissues, skin, bone, blood vessels, and neurons. The aromatase deficiency and excess both are associated with disorders and diseases. In both conditions (ie deficiency or excess) the result will be androgen imbalance, whereby excess testosterone remains without conversion in case of deficiency and excess production of estrogen in case of the excessive aromatase enzyme. The enzyme has been in limelight due to the utilization of its inhibitors in controlling breast cancer. This book focuses on aromatase enzyme in the normal body and diseases caused by its abnormality. Following topics will be covered in greater detail in the book: Normal molecular structure and function of aromatase; Role of aromatase in embryonic development; Role of aromatase in the nervous system; Aromatase in Breast diseases; Aromatase in uterine diseases; Aromatase in prostate disorders; Medicinal use of aromatase inhibitors.