Open access peer-reviewed Edited Volume

Aromatase - Normal Function in Human Body and Associated Disorders

Binafsha Syed

Liaquat University of Medical & Health Sciences


Jawaid Naeem Qureshi

University of Modern Sciences, Tando Mohammad Khan


Aromatase Enzyme Normal Function Embryonic Development Aromatase Enzyme in Nervous System Neuronal Protection Aromatase Enzyme in Breast Cancer Benign Breast Diseases Aromatase Enzyme in Uterine Diseases Uterine Fibroid Aromatase Inhibitors Bone Diseases

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About the book

Aromatase is an enzyme coded by the CYP19 gene located on chromosome 15q21. The enzyme catalyzes the production of estrogen from androgen (ie testosterone and androstenedione) in the form of estrone and 17β-estradiol. Aromatase is normally located in the endoplasmic reticulum of the cells in adrenal glands, ovaries, testes, placenta, fatty tissues, skin, bone, blood vessels, and neurons. The aromatase deficiency and excess both are associated with disorders and diseases. In both conditions (ie deficiency or excess) the result will be androgen imbalance, whereby excess testosterone remains without conversion in case of deficiency and excess production of estrogen in case of the excessive aromatase enzyme. The enzyme has been in limelight due to the utilization of its inhibitors in controlling breast cancer. This book focuses on aromatase enzyme in the normal body and diseases caused by its abnormality. Following topics will be covered in greater detail in the book: Normal molecular structure and function of aromatase; Role of aromatase in embryonic development; Role of aromatase in the nervous system; Aromatase in Breast diseases; Aromatase in uterine diseases; Aromatase in prostate disorders; Medicinal use of aromatase inhibitors. 

Publishing process

Book initiated and editor appointed

Date completed: October 15th 2019

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Deadline Extended: Open for Submissions

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Deadline for full chapters: January 4th 2020

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Review results due: March 24th 2020

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Expected publication date: May 23rd 2020

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About the editor

Binafsha Syed

Liaquat University of Medical & Health Sciences

BINAFSHA MANZOOR SYED has earned her Bachelor of Medicine, Bachelor of Surgery in 2002 from Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan. She got her PhD in Breast Surgery/Clinical Sciences in 2012 from School of Clinical Sciences, The University of Nottingham, England. She is currently serving as the Director ORIC & MRC, and Head of Clinical Research Division, Medical Research Centre, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan. Dr. Syed’s research interest is mainly focuses on Cancer in particular therapeutic targets. She conducts regular workshops on research subjects. She is also Master trainer for PhD Supervisors training. She is principal investigator and lead in two key projects to study: 1) Molecular pattern of Breast cancer in Pakistani population and 2) Biological characterization of colorectal cancers in correlation with clinical parameters and outcome; funded by Higher Education Commission of Pakistan. She has published more than 21 papers in international peer-reviewed journals, she a many abstracts presented at International platforms. She is also author of three book chapters on different topics on breast cancer published by International Publishers.

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