Descriptive characteristics overall and by ethnicity (n = 10,840).
\r\n\tThe formation and development of seagrass meadows take many years. Among all the plant habitats in the world, the most carbon storage feature belongs to seagrass with 2000 tons/ha. Posidonia oceanica is the most important seagrass species for primary production and is endemic to the Mediterranean. This species is a perennial herb that spreads to a depth of 45 meters on the Mediterranean coast and can live up to 30 years. Their presence is indicative of clean seas.
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Gaze",coverURL:"https://cdn.intechopen.com/books/images_new/3435.jpg",editedByType:"Edited by",editors:[{id:"71983",title:"Dr.",name:"David C.",surname:"Gaze",slug:"david-c.-gaze",fullName:"David C. Gaze"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"79795",title:"Parental Education, Ethnicity, and Functional Connectivity between Nucleus Accumbens and Frontoparietal Network",doi:"10.5772/intechopen.101335",slug:"parental-education-ethnicity-and-functional-connectivity-between-nucleus-accumbens-and-frontoparieta",body:'The right and left nucleus accumbens (NAcc) are subcortical brain structures, located within the ventral striatum, that serve as a key limbic-motor interface, and have an important role in Pavlovian learning [1, 2]. This means that the right and left NAcc contribute to the regulation of emotional and motivation processing [3], incentive salience [4], pleasure, reward, and reinforcement [5]. In addition, neural reactivity to food- and/or drug-related reward cues evokes robust dopamine responses in the right and left NAcc [1]. This suggests that as parts of the brain reward system, the right and left NAcc function reflects how individuals respond to cues that signal a potential reward [1]. The right and left NAcc have also been implicated in obesity [2, 6], food addiction [7], tobacco, alcohol, and drug-seeking behaviors [8, 9, 10], obsessive-compulsive disorder [11, 12], depression [13], and anxiety [12].
To fulfill their functions, the right and left NAcc communicate with a number of large-scale brain networks such as the frontoparietal network (FPN) [14, 15, 16]. Neuroimaging studies have revealed some alterations of the connectivity between the NAcc and FPN as an indicator of altered NAcc function [15]. The FPN, also known as the central executive network (CEN), is a large-scale brain network that works with the NAcc, striatum, and basal ganglia [17]. FPN is implicated in the cognitive control [18], attention [19], problem-solving [19], and working memory [19]. Altered FPN function is linked to attention-deficit/hyperactivity disorder (ADHD) [18, 20], cocaine addiction [21], and several mental disorders [22] in children and adolescents. Disruption in the FPN during cognitive control tasks is a common element of schizophrenia, bipolar disorder, unipolar depression, anxiety, and substance use disorders [23].
Functional magnetic resonance imaging (fMRI) techniques have expanded what we know about functional connectivity across brain regions and networks. Resting-state functional connectivity (rsFC) investigates the temporal correlation of the spatially distributed brain regions’ activity at the resting state (i.e., when the participant has not engaged in an explicit task yet) [24]. rsFC allows us to identify spontaneous brain activity patterns, which can provide insight into neural activity patterns [25]. One advantage of rsFC is that it can explore networks not easily assessed during tasks and activities. Finally, rsFC tends to be free from bias in task selection and allows relatively easy data collection [25].
The frontoparietal-accumbal connectivity has a role in motivated behavior, food seeking, emotion regulation, food preference, obesity, eating disorders, and dopaminergic and reward systems of the brain [14, 15, 26, 27]. Decreased functional connectivity between the NAcc and the FPN is seen in depression [28]. An increase in the functional connectivity between the FPN and the NAcc is seen following mindfulness training [29]. Connectivity between the right NAcc and the FPN is also associated with substance use and cognitive control [30].
In comparison to peers with high parental education, children from low parental education have worse brain development [31]. The effects of parental education are well described on brain reward system, inhibitory control, cognitive development [32], language [33], executive function [33], and school achievement [32]. Low parental education is a risk factor for several mental, physical, and behavioral problems [32] including anxiety [34], depression [34], substance use problems [35, 36, 37], early initiation of sexual behavior [38], delinquency [39], obesity [40], and high blood pressure [41]. Parental education reduces children’s antisocial behaviors [42], externalizing problems [43], anxiety and depression [34], behavioral problems [44], psychiatric disorders [44], mental health problems [45], tobacco dependence and aggression [46], and school problems [47] in children and adolescents. High parental education is linked to the size and function of the NAcc [48], thalamus [49], hippocampus [50], amygdala [34], and cerebral cortex.
According to the Minorities’ Diminished Returns (MDRs) framework, parental education produces unequal outcomes for subpopulations [51, 52]. Additionally, based on the MDRs, ethnic minority children are less likely to have equal opportunities to gain from their parents’ education to ensure health outcomes [53, 54]. Stratification, racism, segregation, and marginalization are shown to decrease parental education’s effects on developmental outcomes for ethnic minorities [55, 56]. However, most of the MDRs’ literature is on Black, rather than Latino, children [49, 57, 58]. While we know about the poor attention [59], low school performance [60], high reward dependence [61], impulsivity [62], suicide [63], aggression [64], depression [65], and problem behaviors [66] of Black children with highly educated parents, very limited knowledge exists on Latino children.
According to Harrist and Criss, influences of parental conditions such as parental education are not additive to the effects of other social and behavioral determinants. There are complex moderated mediational influences of parental conditions that are beyond additive effects and may be sub-additive, synergistic, or multiplicative. These effects also vary across diverse groups of families with different socioeconomic and demographic backgrounds [67]. For example, parental education may have diminished influences on children brain development of Black than White families, in part because structural racism may reduce what parental education can do for a Black child [68]. Thus, there is an interest to test heterogeneity of the effects of parental conditions and to investigate the multiplicative and non-additive effects of parental resources and other factors that impact child development [67]. While these differential effects of parental education are shown for structure and function of some brain regions such as amygdala [69], thalamus [70], hippocampus [71], and cerebral cortex [68, 72, 73], less is known about heterogeneity of the effects of parental education on NAcc.
Previous neuroimaging studies have shown the association between parental education and children’s brain function and structure [56, 65]. Different from other socioeconomic status (SES) indicators such as income and poverty, parental education tends to represent an aspect of SES that is not represented by the presence of financial or material resources in the family [74]. Still, there continues to be a lack of studies on the effects of parental education on brain functional connectivity of the NAcc and FPN in group differences at the resting state. Likewise, it is necessary to examine the connectivity between the right and left NAcc and FPN that may reflect reward salience, reward process, cognitive control [75, 76, 77], and various cognition, emotions, and psychological problems [75, 76].
Using a sample of 9/10-year-old preadolescents from the Adolescent Brain Cognitive Development research (ABCD) study [75, 78], the present study had two aims: first, to investigate the correlation between parental education and rsFC between the right and left Nacc and FPN; and second, to examine ethnic heterogeneity in this correlation. We hypothesized that parental education would be positively associated with the functional connectivity of the right and left NAcc and FPN, and that there would be a weaker effect of parental education on the right and left NAcc functional connectivity with FPN for Latino than non-Latino preadolescents.
Data for this secondary analysis came from baseline (wave 1) of the Adolescent Brain Cognitive Development (ABCD) study. The ABCD is an unprecedented study in the examination of children’s brain development [75, 79]. The ABCD study is a longitudinal study of a diverse sample of children from age 9 to 10 to their early adulthood [80]. For more information regarding the ABCD sample, methods, measures, and imaging techniques, please see here [80].
The ABCD study is a multi-site longitudinal study that has recruited 11,875 children aged 9–10, from 21 cities across different states, to characterize their psychological and neurobiological development from early adolescence to early adulthood [78]. Most of the participants were recruited through schools across the 21 study sites [81]. Because of well-designed and performed sampling process, the ABCD study sample has generated a sample that although is not nationally representative, it is a balanced sample that has a strong proxy of US adolescents [81]. Thus, the ABCD sample is a close approximation of US children in terms of distribution of age, SES, ethnicity, sex, and urbanicity [81].
For this analysis, we only used the ABCD baseline sample. We included the ABCD study regardless of their race, ethnicity, and psychopathologies [81]. However, we limited the sample to those who had complete data on our variables and met satisfactory imaging quality. Our analytical n for the analyses *presented here is 7959.
The study variables included parental education (independent variable), children’s ethnicity (moderator), ethnicity, age, race, sex, parental marital status (confounders), and NAcc functional connectivity with the FPN, separately calculated for the right and left (dependent variables).
We used the Data Exploration and Analysis Portal (DEAP), a user-friendly online platform for multivariable analysis of the ABCD data. For multivariable analyses, two mixed-effects regression models were estimated (Supplementary Table).
The original ABCD research protocol received Institutional Review Board (IRB) approval in several institutions, including the University of California, San Diego (UCSD). Additionally, we received the ABCD data through an agreement between Charles R. Drew University and NIH/NDA. As the ABCD data were fully de-identified, our study was considered to be a nonhuman subject research. This exempted our study from a full review. Besides, all children in the ABCD study provided verbal assent to the protocol approved by the IRB, and all parents/caregivers signed the written informed consent form [80].
The present study used data from a large sample of 10,840 preadolescents between 9 and 10 years old (
N | n | n | n | |
---|---|---|---|---|
N | 10,840 | 8690 | 2150 | |
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
Age (month) | 119.06 (7.51) | 119.18 (7.48) | 118.61 (7.58) | 0.002 |
Right NAcc functional connectivity with the FPN | −0.01 (0.15) | −0.01 (0.15) | −0.02 (0.15) | 0.043 |
Left NAcc functional connectivity with the FPN | −0.06 (0.17) | −0.06 (0.17) | −0.06 (0.17) | 0.421 |
Parental education | ||||
<HS diploma | 470 (4.3) | 184 (2.1) | 286 (13.3) | <0.001 |
HS diploma/GED | 970 (8.9) | 634 (7.3) | 336 (15.6) | |
Some college | 2815 (26.0) | 2071 (23.8) | 744 (34.6) | |
Bachelor | 2791 (25.7) | 2393 (27.5) | 398 (18.5) | |
Postgraduate degree | 3794 (35.0) | 3408 (39.2) | 386 (18.0) | |
Race | ||||
White | 7071 (65.2) | 5798 (66.7) | 1273 (59.2) | <0.001 |
Black | 1654 (15.3) | 1573 (18.1) | 81 (3.8) | |
Asian | 256 (2.4) | 235 (2.7) | 21 (1.0) | |
Other/mixed | 1859 (17.1) | 1084 (12.5) | 775 (36.0) | |
Sex | ||||
Female | 5194 (47.9) | 4162 (47.9) | 1032 (48.0) | 0.949 |
Male | 5646 (52.1) | 4528 (52.1) | 1118 (52.0) | |
Marital status | ||||
No | 3413 (31.5) | 2532 (29.1) | 881 (41.0) | <0.001 |
Yes | 7427 (68.5) | 6158 (70.9) | 1269 (59.0) |
Descriptive characteristics overall and by ethnicity (n = 10,840).
Notes: Source: Adolescent Brain Cognitive Development (ABCD) Study.
The fit of the mixed-effects regression model is summarized in Table 2. Models with the interaction effects between parental education and ethnicity showed a better fit when compared with main effect models that only included ethnicity and parental education. This shows that interaction between parental education and ethnicity contributes more to explaining the variance of the outcome for both the right and left NAcc with FPN connectivity.
Right | Left | |||
---|---|---|---|---|
Main effect | Interaction effect | Main effect | Interaction effect | |
N | 10,840 | 10,840 | 10,856 | 10,856 |
R-squared | 0.00451 | 0.00559 | 0.00347 | 0.00421 |
ΔR-squared | 0.00104 | 0.00241 | 0.00109 | 0.00189 |
ΔR-squared (%) | 0.1% | 0.24% | 0.11% | 0.19% |
Effect sizes and % variance explained by models.
As shown by Table 3 and Figure 1, parental education showed a positive association with the functional connectivity between the right and left NAcc with FPN. This positive correlation suggests that children with higher parental education have a stronger rsFC between the right NAcc and FPN.
Right | Left | ||||||||
---|---|---|---|---|---|---|---|---|---|
B | SE | Sig | b | SE | Sig | ||||
Parental education | |||||||||
HS diploma/GED | 0.01328 | 0.00859 | 0.1223612 | 0.00119 | 0.01272 | 0.925758 | |||
Some college | 0.01023 | 0.00772 | 0.1855986 | −0.00853 | 0.01186 | 0.4721566 | |||
Bachelor | 0.02173 | 0.00802 | 0.0067889 | ** | 0.00371 | 0.01208 | 0.7589529 | ||
Graduate degree | 0.01789 | 0.00800 | 0.0253812 | * | 0.00292 | 0.01203 | 0.8083342 | ||
Hispanic | −0.00353 | 0.00404 | 0.3819443 | −0.02965 | 0.01469 | 0.0436103 | * | ||
Race | |||||||||
Black | −0.01198 | 0.00471 | 0.0109603 | * | −0.01335 | 0.00483 | 0.0056677 | ** | |
Asian | −0.01446 | 0.00967 | 0.1350259 | −0.01465 | 0.00967 | 0.1298128 | |||
Other/mixed | −0.00560 | 0.00411 | 0.1724601 | −0.00572 | 0.00411 | 0.1634748 | |||
Age | 0.00021 | 0.00019 | 0.2671881 | 0.00022 | 0.00019 | 0.2638408 | |||
Sex | 0.00111 | 0.00292 | 0.7044723 | 0.00114 | 0.00292 | 0.6950323 | |||
Married family | 0.00662 | 0.00362 | 0.0670059 | # | 0.00688 | 0.00362 | 0.057242 | # | |
Parental education (HS Diploma/GED) × hispanic | 0.01551 | 0.01763 | 0.379094 | ||||||
Parental education (some college) × hispanic | 0.03629 | 0.01586 | 0.0221188 | * | |||||
Parental education (bachelor) × hispanic | 0.03788 | 0.01680 | 0.0241787 | * | |||||
Parental education (postgraduate degree) × hispanic | 0.01227 | 0.01677 | 0.4644527 |
Mixed-effects regressions on the effects of parental education and ethnicity on the functional connectivity between the frontoparietal network and nucleus accumbens (right).
Notes: Source: ABCD Study; Mixed-effects regression model is used; all covariates such as race, ethnicity, age, sex, family, and site were controlled.
Association between parental education and functional connectivity between the right NAcc and FPN overall and by ethnicity.
Table 4 and Figure 1 show that parental education had a stronger positive association between parental education and the right FPN resting-state functional connectivity in Hispanic children than non-Hispanic children.
Right | Left | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
B | SE | b | SE | |||||||
Parental education | ||||||||||
HS diploma/GED | 0.01432 | 0.00971 | 0.140307 | 0.04212 | 0.01439 | 0.0034347 | ** | |||
Some college | 0.02458 | 0.00873 | 0.0048772 | ** | 0.05058 | 0.01341 | 0.0001636 | *** | ||
Bachelor | 0.01292 | 0.00907 | 0.154451 | 0.03647 | 0.01367 | 0.0076431 | ** | |||
Graduate degree | 0.01748 | 0.00905 | 0.053342 | # | 0.04149 | 0.01361 | 0.0023007 | ** | ||
Hispanic | −0.00232 | 0.00457 | 0.612231 | 0.03703 | 0.01661 | 0.0257893 | * | |||
Race | ||||||||||
Black | 0.01807 | 0.00533 | 0.0007057 | *** | 0.01868 | 0.00546 | 0.0006308 | *** | ||
Asian | −0.00606 | 0.01091 | 0.578768 | −0.00603 | 0.01091 | 0.5804568 | ||||
Other/mixed | 0.01120 | 0.00465 | 0.0159763 | * | 0.01138 | 0.00465 | 0.0143508 | * | ||
Age | 0.00013 | 0.00022 | 0.541902 | 0.00014 | 0.00022 | 0.5346076 | ||||
Sex | 0.00767 | 0.00329 | 0.0195458 | * | 0.00759 | 0.00329 | 0.020868 | * | ||
Married family | 0.00036 | 0.00409 | 0.9291253 | 0.00030 | 0.00410 | 0.9418007 | ||||
Parental education (HS diploma/GED) × Hispanic | −0.05046 | 0.01993 | 0.0113542 | * | ||||||
Parental education (some college) × Hispanic | −0.04662 | 0.01793 | 0.0093157 | ** | ||||||
Parental education (bachelor) × Hispanic | −0.03491 | 0.01899 | 0.066009 | # | ||||||
Parental education (postgraduate degree) × Hispanic | −0.03745 | 0.01895 | 0.0482004 | * |
Mixed-effects regressions on the effects of parental education and ethnicity on the functional connectivity between the frontoparietal network and nucleus accumbens (left).
Notes: Source: ABCD Study; mixed-effects regression model is used; all covariates such as race, ethnicity, age, sex, family, and site were controlled.
As shown by Table 4 and Figure 2, parental education showed a positive association with the functional connectivity between the right and left NAcc with FPN. This positive correlation suggests that children with higher parental education have stronger rsFC between left NAcc and FPN.
Association between parental education and functional connectivity between the left NAcc and FPN overall and by ethnicity.
Table 4 and Figure 2 show that parental education had a negative interaction with ethnicity on the functional connectivity between the FPN and the left NAcc. This interaction was indicative of a weaker positive association between parental education and the left FPN-NAcc resting-state functional connectivity in Hispanic children than non-Hispanic children.
Our first aim showed a positive correlation between parental education and the NAcc resting-state functional connectivity with the FPN. Our second aim showed ethnic variation in the association between parental education and the right and left NAcc resting-state functional connectivity with the FPN. That is laterality, ethnicity, and parental education all show multiplicative effects on NAcc resting-state functional connectivity with the FPN. While we found a stronger correlation between parental education and the resting-state FPN’s functional connectivity with the right NAcc in Latino than non-Latino children, parental education showed a weaker association with the same connectivity for the left NAcc. The finding on the right NAcc contrasts with the MDRs, but the finding on the left NAcc supports the MDRs’ theory, which shows a weaker association between SES and brain development for marginalized and minority children than White children.
Our first finding is in agreement with other work showing the effects of parental education on brain structure [33], performance in several cognitive domains [82], and mental health problems, such as anxiety and depression [34]. However, most of what we know about SES effects are limited to specific brain regions [74, 83, 84], rather than rsFC. Past research has established a link between parental education and the size and activity of brain structures, such as the NAcc [48], amygdala [34], hippocampus [50], and thalamus [49]. In a study of examining a sample of 283 children and adolescents aged 4–18, higher parental education significantly predicted greater cortical thickness in the right anterior cingulate and left superior frontal gyrus [85]. Among 9475 children from the ABCD study, parental education was associated with reduced within and between sensorimotor network connectivity and increased sensorimotor network connectivity to frontal functional networks [76]. Furthermore, in line with our finding, higher parental education is shown to be linked to the development of frontoparietal connectivity in children [76]. Neurodevelopmental correlates of parental education may mediate why parental education is linked to behaviors [86], executive functions [33], reading ability [87], spatial skills, and inhibitory control [55]. Importantly, however, no studies to our knowledge have examined the associations between parental education and rsFC within the NAcc and FPN.
The effect of parental education on brain function can be explained by underlying mechanisms [88], such as cognitive stimulation available at home, parent–child interactions, and home learning environment, which all predict brain development [33, 88]. For example, more educated parents dedicate more time for their children in ways that seem to improve their children’s development [89, 90]. Likewise, more educated parents appear to have higher expectations for their children, provide more stimulating learning materials, use more complex language and speech patterns, and engage more with their children’s learning [89, 91]. These can help promote children’s cognitive development [90]. Furthermore, the skills obtained from formal education appear to enable parents to arrange their activities in ways that allow them to effectively accomplish their parenting goals [88].
The results of the right NAcc-FPN connectivity were not in line with what is shown from the comparison of Black and White children. According to the MDRs’ theory, parental education is more protective for White children than Black children. This finding was observed for the left NAcc-FPN connectivity. Similar to our finding on the left side, the effects of SES on attention [59], reward dependence [61], school performance [60], aggression [64], impulsivity [62], suicide [63], anxiety [92], and problem behaviors [66] are shown to be weaker in Black than White adolescents. This is the first study on the MDRs of parental education for NAcc functional connectivity with the FPN in Latino children. Even when MDRs exist, the right and left NAcc findings may vary largely.
Parental education has different and group-specific effects on children and youth brain development. This means that SES resources and ethnicity may have multiplicative, rather than additive, effects on the right NAcc resting-state functional connectivity with FPN. In this study and all the MDRs’ literature, ethnic variation in the SES effects is shaped by social rather than biological mechanisms. Thus, in our study, ethnicity is a social rather than biological factor. Consequently, the differential treatment of society, which is preventable, has resulted in the ethnic differences. Importantly, we consider race as a proxy of racism, such as labor market discrimination, low school quality, segregation, and differential policing, that results in reduced effects of parental education, even for more educated people [93].
The present study had some limitations. Firstly, a cross-sectional design limits any inference of causal links between parental education, ethnicity, and NAcc functional connectivity with the FPN. Secondly, we only studied parental education; other SES indicators were not included. Moreover, we did not examine how other factors, such as neighborhood context, stress, and social adversities, mitigate these effects across groups. Thirdly, Latino people are highly diverse. Cuban, Mexican, and Puerto Rican families differ in their history, culture, neighborhoods, SES, and other factors that may alter SES effects.
Although high NAcc resting-state functional connectivity with FPN is under the influence of parental education, ethnicity, and laterality, these effects are multiplicative rather than additive. This means that, while the parental education gradient was stronger for the right NAcc in Latino than non-Latino American preadolescents, the opposite finding was observed for the left NAcc. Due to qualitative differences in the lived conditions of ethnic groups in the United States, various subgroups may show different SES effects on brain development.
Right | Left | |
---|---|---|
Model 1 | rsfmri_cor_network.gordon_frontoparietal_subcort.aseg_accumbens.area.rh ∼ high.educ.bl + hisp + race.4level + age + sex + married.bl Random: ∼(1|rel_family_id) | rsfmri_cor_network.gordon_frontoparietal_subcort.aseg_accumbens.area.lh ∼ high.educ.bl + hisp + race.4level + age + sex + married.bl Random: ∼(1|rel_family_id) |
Model 2 | rsfmri_cor_network.gordon_frontoparietal_subcort.aseg_accumbens.area.rh ∼ high.educ.bl + hisp + race.4level + age + sex + married.bl + high.educ.bl * hisp Random: ∼(1|rel_family_id) | rsfmri_cor_network.gordon_frontoparietal_subcort.aseg_accumbens.area.lh ∼ high.educ.bl + hisp + race.4level + age + sex + married.bl + high.educ.bl * hispRandom: ∼(1|rel_family_id) |
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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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Beloborodova",profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9731",title:"Oxidoreductase",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9731.jpg",slug:"oxidoreductase",publishedDate:"February 17th 2021",editedByType:"Edited by",bookSignature:"Mahmoud Ahmed Mansour",hash:"852e6f862c85fc3adecdbaf822e64e6e",volumeInSeries:19,fullTitle:"Oxidoreductase",editors:[{id:"224662",title:"Prof.",name:"Mahmoud Ahmed",middleName:null,surname:"Mansour",slug:"mahmoud-ahmed-mansour",fullName:"Mahmoud Ahmed Mansour",profilePictureURL:"https://mts.intechopen.com/storage/users/224662/images/system/224662.jpg",institutionString:"King Saud bin Abdulaziz University for Health Sciences",institution:{name:"King Saud bin Abdulaziz University for Health Sciences",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9742",title:"Ubiquitin",subtitle:"Proteasome Pathway",coverURL:"https://cdn.intechopen.com/books/images_new/9742.jpg",slug:"ubiquitin-proteasome-pathway",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"af6880d3a5571da1377ac8f6373b9e82",volumeInSeries:18,fullTitle:"Ubiquitin - Proteasome Pathway",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9002",title:"Glutathione System and Oxidative Stress in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9002.jpg",slug:"glutathione-system-and-oxidative-stress-in-health-and-disease",publishedDate:"August 26th 2020",editedByType:"Edited by",bookSignature:"Margarete Dulce Bagatini",hash:"127defed0a50ad5ed92338dc96e1e10e",volumeInSeries:17,fullTitle:"Glutathione System and Oxidative Stress in Health and Disease",editors:[{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:3},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:8},{group:"subseries",caption:"Chemical Biology",value:15,count:10}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:3},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:301,paginationItems:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"ofsBook.detail",path:"/welcome/174d974e744ab42717bb8da4add5b6b0",hash:"",query:{},params:{hash:"174d974e744ab42717bb8da4add5b6b0"},fullPath:"/welcome/174d974e744ab42717bb8da4add5b6b0",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()