Open access peer-reviewed Edited Volume

Current State of the Art in Cysticercosis and Neurocysticercosis

Jorge Morales-Montor

National Autonomous University of Mexico

A pioneering researcher in Neuroinmunoendocrinology of several parasite infections, including cysticercosis. He has published over 153 papers, has edited 12 books, and written around 50 book chapters. Head of the Laboratory of Neuroimmunoendocrinology, Institute of Biomedical Research in UNAM, Mèxico.

Co-editors:

Abraham Landa

National Autonomous University of Mexico

A pioneering researcher in molecular parasitology of Taenia solium cysticerci. He was part of the team that sequenced the Taenia solium genome. He has published over 33 papers on cysticercosis. Head of the Laboratory of Molecular Parasitology in UNAM, Mèxico.

Luis Terrazas

National Autonomous University of Mexico

A pioneering researcher in studying the immunology of taeniasis/cysticercosis, appointed Head of the Unit of Experimental Biomedicine. Recently appointed as Director of the Office of Development and Cultural and Scientific Relationships in the School of Superior Studies Iztacala, UNAM.

Covering

Delivering Methods DNA Vaccines Diagnostic of Cysticercosis Diagnostic of Taeniosis Epidemiology of Cysticercosis Epidemiology of Neurocysticercosis New Drugs Available Drug-Design Taenia Solium Clinical Trials Taenia Crassiceps Immune Response

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About the book

Cysticercosis, caused by the metacestode stage of Taenia solium, is a serious health and veterinary problem in many developing countries and is considered one of the most important neglected tropical diseases in developed countries. In humans, T. solium cysticerci cause neurocysticercosis, which affects ~50 million people worldwide, and it has been considered as an emergent disease in the United States. T. solium also infects pigs, its intermediate host, leading to major economic losses.

When humans ingest undercooked contaminated pork meat, the adult worm develops in the small intestine. After two months of asymptomatic infection, this tapeworm starts producing thousands of eggs, that, once released with the stools, can contaminate the environment, infecting pigs (rapidly differentiating into cysticerci mainly in the muscle) and humans (where most severe symptoms are observed due to the presence of cysticerci in the brain). Thus, maintenance of the parasite's life cycle depends on the adult tapeworm development. Even in communities which do not rear or consume pigs, human neurocysticercosis can be found, because of the presence of a tapeworm carrier. Furthermore, tapeworm development in turn depends on scolex evagination, the initial step through which a single cysticercus becomes an adult parasite with the capability of producing infective eggs. A great deal of scientific advances on the field has been producing in recent times, all on the most important fields of the disease: vaccination, epidemiology, current drug design, diagnostic and host-parasite interaction at all levels. However, to date, there is no actualized book dealing with the recent advances in such an important disease in the world.

This book will intend to provide the reader with a comprehensive overview of the current state-of-the-art in cysticercosis featuring an easy-to-follow, vignette-based format that focuses on the most important evidence-based developments in this critically important area.

Publishing process

Book initiated and editor appointed

Date completed: November 23rd 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: February 19th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 10th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: July 9th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Jorge Morales-Montor

National Autonomous University of Mexico

Dr. Jorge Morales-Montor studied biology at the Iztacala UNAM Faculty of Higher Studies, obtaining the title in 1992. He obtained a doctor’s degree in October 1997. His doctoral thesis was recognized with the Lola and Igo Flisser-PUIS Award to the best graduate thesis at thenational level in theareaofparasitology,a recognition that he has also later received as a tutor, since one of his doctorate students won the same award in 2008. In November 1997, he began a postdoctoral stay at theDepartment of CellularBiology at the UniversityofGeorgia, USA, in the laboratory of Dr. Raymond T. Damia´n, one of the most recognized parasitologists in the world. Dr. Morales received a grant from the Fogarty Foundation (one of the most prestigious in Ibero-America) to carry out research on schistosomiasis in the baboon, being a Pan American Fellow for 4 years. Dr. Ray Damia´n would write years later, which assured that without a doubt, Jorge Morales-Montor had been the best postdoctoral researcher with whom he collaborated in his nearly 35-year career. He was repatriated to Mexico in 2001 by CONACYT and joined the Department of Immunology of the Institute of Biomedical Research of UNAM as Associate Investigator “C”. In just 9 years, he managed to climb the entire ladder of university academic positions, to receive its tenure track positionas a Definitive C Titular Researcher at the Institute of Biomedical Research. The same is reflected in the Level of Premiums for Academic Performance, where it has reached the highest level currently: Level D, for the third consecutive period. Also in the National System of Researchers, he has had the same growth, starting in 1997 as a candidate, and, to date, being promoted to Level III, the highest, for the third consecutive period. Dr.Morales-Montor has been invited to participate in different congresses (more than 100). In addition, he is part of the editorial committee of more than 15 indexed international journals, nd Editor in Chief of 3. Some of his most important contributions are partially determining the role of steroid hormones in immunological sexual dimorphism, in the polarization of the immune response, and in the antigenic presentation.He has alsomade very relevant studies in relation to how different physiological stages, how the estrous cycle, age, sex, or pregnancy affect the functioning of the immune, endocrinological, and nervous system, and what molecules could be the determinants in this context of net. It has been shown that the central nervous system is involved in the regulation of the immune response to parasitic infections, and the effect of this activation on various behaviors of the infectedhost. But the centralnervous system has provided interesting data about its impact in the parasitology approach. For instance, a modern concept is depicted by how the central nervous system modulates the gene and proteomic regulation of the different sex steroids in parasites,which are involved in important functions of parasites such as establishment, growth, and reproduction. Finally, the practical use of the knowledge acquired by the earlier mentioned studies has been applied to a theory that he calls old drugs, new uses: the use of hormones and antihormones as antiparasitic therapy. He has also entered the study of environmental contamination, specifically endocrine disruptors and disease, studying their role in two very important diseases in the country: cancer and obesity, projects with which he has formed two consortiums of investigation. Its results are a very important contribution to the health of both Mexicans and Latin Americans in general, since this is where serious health problems related to parasitic infections, cancer, and obesity are concentrated.His investigations are characterized by an exhaustive and meticulous experimental work, and his scientific production already has 153 articles in international indexed journals, and the majority as the first author or corresponding author. He hasmore than 3000 citations to his works, and an h-index of 29, one of the highest in the country’s scientific community. His articles published in high-impact international journals include Nature, PlosOne, Journal of Immunology, Journal of Infectious Diseases, Journal of Interferon and Cytokine Research, and among others. In fact, recently, his 2015 article, The Role of Cytokines in Breast Cancer Development and Progression, published in the Journal of Interferon and Cytokine Research, was the subject of a press release released by Mary Ann Liebert Publications. This is sent all over the world, to newspapers, Journals, scientists, radio, TV, popular magazines, to what is considered as a very important contribution in a certain area of science. Very few scientific articles are released as “press release.” He is also the 4th most cited author in the area of parasitology in the country. He has also edited several books and published more than 55 chapters in books, national and foreign. In this area, recently, the chapter “The Role of Sex Steroids in the Host-Parasite Interaction,” published in the international book “Sex Steroids” in 2012, reached the figure of 68,000 downloads, which means the degree of attention that has after receiving his work; the foregoing makes it clear that Dr. Morales-Montor’s work is highly relevant and widespread amongthenational and international academic community, and his brilliant career has earned him more than 30 awards, such as the Miguel Aleman Valdez Award in the area of Health 2006, the Distinction National University for Young Academics in the area of Research in Natural Sciences 2006, the CANIFARMA Veterinary Prize 2007 and 2009 the Heberto Castillo Martı´nez Capital City Award for Young Latin American Academics in Basic Research, and for the third consecutive congress, in 2011, one of his works was awarded the “Dr. Jose Eleuterio Gonza´lez” Award, for the best work of and research at the XXVI National Congress of Research in Medicine, to name just a few of its achievements. He has also mentored and graduated more thn 60 students at all levels (Baccularate, Masters and Doctorate) and also been awarded many distinctions, such as joining the Mexican Academy of Sciences (2005), and being one of the few Mexican scientists to be inducted to the Latin American Academy of Sciences (2008), The National Academy of Medicine, the New York Academy of Sciences, the American Association of Immunologists are deserved recognitions for his academic quality and career. His academic leadership is reflected in the trust and respect that his peers confer on him, having been President of the Mexican Society of Parasitology (one of the oldest and most prestigious scientific societies in the country) and currently being President, and founding member, of the Mexican Society of Neuroimmunoendocrinology, since 2011. Due to its scientific curiosity, it is in the process of founding the Mexican Society for Translational Environmental Biomedicine. He has been invited to edit special volumes in various magazines with international circulation and is a member of the editorial committee of magazines of importance in his area of work, such as ParasiteImmunology, The OpenParasitologyJournal, among others. He has been a jury for the Arturo Rosenblueth Awards for the best CINVESTAV Doctoral Thesis, a jury for the Lola and Igo Flisser-PUIS 2010 Awards, and a jury for the Heberto Castillo Award, for the best Latin American Researcher 2012, awarded by the Federal District Government. It is noteworthy that he is an outstanding scientist, who has contributed to the scientific research of Mexico with the generation of new frontier knowledge in the world and with the training of high-level human resources.

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