Open access peer-reviewed Edited Volume

Cardiac Troponins - Analytical and Clinical Performance for the Detection of Cardiovascular Disease

David C. Gaze

University of Westminster


Cardiac Troponins Antibody Selection Analytical Sensitivity High Sensitive Troponin Prognosis Risk Stratification CP in Kidney Disease Cardiac Troponins in Exercise Cardiac Function Cardiac Output Long Term Risk Prognosis

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About the book

Cardiac markers are the integral to the diagnosis and management of patients with cardiovascular disease (CVD). Classical enzyme biomarkers have been replaced by cardiac troponin (cTn) T (cTnT) and I (cTnI) measurements. Due to their high specificity cTn determinations are considered the gold standard in patients with suspected acute coronary syndrome (ACS). Early contemporary cTn assays were unable to detect circulating protein in healthy individuals. They also demonstrated a late diagnostic window following onset of chest pain, reflecting prognostic risk to the patient. The 99th percentile value of a healthy population is considered the optimal cut point to define an abnormal troponin concentration. With the advent of high sensitivity assays, assay design and analytical performance has an impact not only on the 99th percentile concentration but also the clinical value for diagnosis and prognosis in a range of disease states outside the remit of ACS. This edited volume will discuss how evolving cTn assay design has impacted the analytical performance and clinical utility of cTn in the established acute cardiac setting but will discuss novel uses beyond the ACS continuum. 

Publishing process

Book initiated and editor appointed

Date completed: September 6th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 26th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 14th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 14th 2020

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About the editor

David C. Gaze

University of Westminster

Dr. David Gaze studied biochemistry at undergraduate and Masters level in West Yorkshire followed by a Ph.D. in Clinical Biochemistry in London, United Kingdom. He is currently Lecturer in Clinical Biochemistry at the University of Westminster and Honorary Cardiac Research Scientist within the Department of Chemical Pathology, Clinical Blood Sciences at St George’s Hospital and Medical School, London. He has authored and co-authored in excess of 150 peer-reviewed papers and 200 abstracts, as well as presented at over 50 internationally invited conferences. He has contributed five book chapters to cardiovascular-related textbooks as well as writing a textbook on cardiac troponin. He is a peer reviewer for 25 medical journals. He is the commissioning editor for review articles for the Annals of Clinical Biochemistry & Laboratory Medicine and is Co-editor-in-chief of Practical Laboratory Medicine. His academic research interests are in the development and clinical utility of cardiac biomarkers for the detection of cardiovascular disease with a special interest in the cardiorenal population. He is a member of the Royal Society of Medicine of London; The Association for Clinical Biochemistry, of which he chairs the Clinical Sciences Review Committee for the Annals of Clinical Biochemistry. He is also a member of the American Association of Clinical Chemistry; Institute of Biomedical Sciences; Institute of Biology; European Society of Pathology; The Pathological Society of Great Britain and Ireland and the associate member of the Royal Institution of London. Gaze and colleagues have won a number of awards including two distinguished Abstract awards from the National Academy of Clinical Biochemistry as well as Diploma for Oral Presentation regarding D-dimer, natriuretic peptide and cardiac troponin in dialysis patients presented at the 17th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine and the 60th National Congress of the Netherlands Society of Clinical Chemistry and Laboratory Medicine in Amsterdam in 2007.

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Book chapters authored 5

Books edited 5

Introducing your Author Service Manager

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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