About the book
Neuroblastoma is a complex genetic pediatric malignancy arising from the peripheral nervous system and affects infants and young children with a low survival rate. The source of neuroblastoma is from neural crest cells and the tumor has heterogeneous biological, morphological, genetic, and clinical presentations. There is a significant increase in our understanding of the genetic determinants and molecular events that predispose to the formation of neuroblastoma. Understanding of genetic basis of neuroblastoma has helped us to understand the molecular events which drive tumorigenesis, develop novel therapeutic strategies, and also to precisely stratifying the risk and to interpret the prognosis. This information facilitates identifying the high-risk patients who may get benefitted from combination chemotherapy before surgery or many adjuvant management options (autologous stem cell transplantation, local radiation, or immunotherapy).
The present book shall try to bring the researchers together to describe various characteristics of neuroblastomas including biological characteristics, various molecular markers, clinal behavior, imaging characteristics, management strategies including the role of modern immunotherapy, outcomes in these patients, and future scope of the research.