Open access peer-reviewed Edited Volume


Joseph Shapiro

Marshall University


Zeid Khitan

Marshall University


cardiac outcomes hormones cytokines autoregulation renal function curves physiology vascular proximal tubule distal tubule thick ascending limb collecting duct connecting tubule K (potassium) Cl (chloride) Mg (magnesium) Ca (calcium) acid-base congestive heart failure liver failure ascites edema hypotension

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About the book

This book will collect a series of monographs on the subject of natriuresis. Natriuresis refers to the excretion of sodium by the kidney and is a complex process regulated by a multitude of humoral and physical factors. This topic will be the subject of monographs selected to address topic 2. A considerable amount of this complexity is due to the intrarenal mechanisms involved in determining ultimate sodium excretion which will be addressed in topic 4. These renal mechanism have protean extrarenal manifestations because of the other ions impacted by this process; this is the subject of topic 5. In particular, the cardiovascular system is particularly tied to the topic of natriuresis, and hypertension can often be considered a disease which is largely dependent on such natriuresis. This important area will be covered in topics 1, 3 and 6. In this collection, we hope to share both historical concepts as well as cutting edge information on this topic which is so critical to medicine and public health.

Publishing process

Book initiated and editor appointed

Date completed: October 7th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: February 5th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 16th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: June 15th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Joseph Shapiro

Marshall University

Dr. Joseph I. Shapiro was born in Newark, NJ in 1954. He received a B.A. in Mathematics from the University of Pennsylvania in 1976 and his M.D. from UMDNJ-Rutgers Medical School in 1980. Dr. Shapiro trained in Internal Medicine at Georgetown University Hospital (1980-83) and Nephrology at the University of Colorado (1983-87). He rose through the academic ranks there and moved to the University of Toledo (formerly the Medical College of Ohio) as Professor of Medicine and chief of Nephrology in 1997. He became chairman of Medicine in 1999, serving until 2012 when became Vice President and Dean of the School of Medicine at Marshall University. Dr. Shapiro has been active as a clinician, teacher and researcher. He has received a number of awards for his scholarship, teaching, research and institutional citizenship including induction into Alpha Omega Alpha, Fellowship and Mastership in the American College of Physicians, American Society of Nephrology and American Heart Association and the Arnold P. Gold Humanism in Medicine Award. Recently, Dr. Shapiro was honored by Mastership in the American College of Physicians, an honor bestowed on < 1% of the members of this organization of internal medicine physicians. Dr. Shapiro maintains board certification in both internal medicine and nephrology and is perennially listed on the various “top doctors” lists including Castle Connelly. During this career, Dr. Shapiro has received more than 50M dollars in funding from the NIH as principal or co-principal investigator and authored more than 300 scientific articles, book chapters and patents. Dr. Shapiro has also been active as an entrepreneur, starting several companies based on scientific discoveries.

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Book chapters authored 2

Books edited 0

Introducing your Author Service Manager

Ms. Sara Debeuc

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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