About the book
Ketamine is N-metil-D-aspartate and glutamate receptor antagonist, feniksilidin derivative, with first onset, potent anesthetic agent. Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. It is administered to humans via multiple routes, including intravenous, intramuscular, oral, intranasal, epidural, intrathecal and intrarectal. Behinds the well-known analgesic, amnestic and hypnotic effects of ketamine, he also causes bronchodilatation, protects airway reflexes and spontaneous ventilation and provides hemodynamic stability.
Ketamine is used widely for procedural sedation and premedication in children, during opioid free anesthesia and to increase the duration of spinal block and epidural analgesia. Subdissociative doses of ketamine are effective in treatment of acute postoperative pain and chronic pain especially in cancer patients.
Recently, the popularity of ketamine is growing due to his non-anesthetic and non-analgesic effects, and in clinical practice it is used for the management of immune system disorders, depression and acute brain injury. This book intends to provide the reader with the novel knowledge about ketamine and his effects, and not only in anesthesia"