Open access peer-reviewed Edited Volume

Use and Effects of Ketamine

Antigona Hasani

University of Prishtina


Ketamine Pharmacodynamic Pharmacokinetic Effects Opioid Free Anesthesia Epidural Intrathecal Acute Pain Postoperative Pain Psychotic Effects Depression Non-analgesic Effects

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About the book

Ketamine is N-metil-D-aspartate and glutamate receptor antagonist, feniksilidin derivative, with first onset, potent anesthetic agent. Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. It is administered to humans via multiple routes, including intravenous, intramuscular, oral, intranasal, epidural, intrathecal and intrarectal. Behinds the well-known analgesic, amnestic and hypnotic effects of ketamine, he also causes bronchodilatation, protects airway reflexes and spontaneous ventilation and provides hemodynamic stability.

Ketamine is used widely for procedural sedation and premedication in children, during opioid free anesthesia and to increase the duration of spinal block and epidural analgesia. Subdissociative doses of ketamine are effective in treatment of acute postoperative pain and chronic pain especially in cancer patients.

Recently, the popularity of ketamine is growing due to his non-anesthetic and non-analgesic effects, and in clinical practice it is used for the management of immune system disorders, depression and acute brain injury. This book intends to provide the reader with the novel knowledge about ketamine and his effects, and not only in anesthesia"

Publishing process

Book initiated and editor appointed

Date completed: October 17th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: January 6th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 26th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 25th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Antigona Hasani

University of Prishtina

Dr. Hasani has graduated at the University of Prishtina (Kosovo) in 1987 and completed the specialization in anesthesiology and reanimation at the Marmara University, Istanbul, Turkey, in 1999. She finished the postgraduate studies, defending the Master’s thesis at Medical Faculty of Prishtina (Kosovo) in 2005, in the field of neuroanesthesia. She completed the PhD studies at University 'Kiril at Metodij” in Skopje (Macedonia), defending the Ph.D. thesis in 2011. She was elected as Professor of Anesthesiology and Reanimation at Medical Faculty, University of Prishtina, in 2012. Her clinical and research interests include airway management, pediatric anesthesia, neuroanesthesia and regional anesthesia. Dr. Hasani is the author of a number of scientific papers and three books. She also helped translate one. In 2018 she founded and is the president of Kosova Airway Management Society.

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