Open access peer-reviewed Edited Volume

Animal Models and Experimental Research in Medicine

Mahmut Karapehlivan

Kafkas University

Dr. Karapehlivan is part of the university senate of Kafkas University. So far, he has authored 65 journal papers, 5 book chapters, and 75 other publications. He worked as an assistant professor in the Department of Biochemistry from 2004 to 2009. He earned the title of Associate Professor of Biochemistry in the field of Health Sciences in 2009. Dr. Karapehlivan was appointed Professor in 2014.


Volkan Gelen

Kafkas University

Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.

Abdulsamed Kükürt

Kafkas University, Turkey

Dr. Kükürt has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.


Animal Care and Feeding Breeding Environment Physiological Parameters Biochemical Parameter Genetic and Transgenic Animals Neuronal Activity Brain IRI Renal IRI Therapeutic Agents Hepatotoxicity Immunity

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About the book

Animal models are used to understand physiological, biochemical, and pathological mechanisms of cells, tissues, organs, and systems, to elucidate inter-system relations, to develop new diagnostic methods for diseases or functional disorders, and to develop new strategies for their treatment. When considering the ethical and legal constraints, the need to use animal models maintains its importance from past to present. The success of the research depends on the suitability of the chosen model. For example, while single-celled organisms such as yeast are a convenient model for the study of basic eukaryotic cell functions such as cell cycle regulation, vesicular transport, protein folding, and DNA repair, simple invertebrates such as Caenorhabditis elegans or Drosophila are regarded as good models in studies examining the coordinated functions of genes related to signal transmission or protein-protein interactions. Simple vertebrates (zebrafish, frogs, etc.) or mammals (rat, mouse, rabbit, guinea pig, etc.) are used to establish human disease models or to explain their effects at the organism level. In addition, the use of experimental animals is quite common in experimental medicine research, especially in pharmaceutical developments and molecular pathway studies.

This book aims to discuss current developments such as the definition of model animals, the purposes of using model animals and the diseases in which they are used, the selection of appropriate models and subjects, and the technological methods used in the experimental model.

Publishing process

Book initiated and editor appointed

Date completed: March 18th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: May 27th 2022

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: July 26th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: October 14th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: December 13th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Mahmut Karapehlivan

Kafkas University

Dr. Karapehlivan was born in 1969, in Saruhanlı county of Manisa-Türkiye. He completed his primary and secondary school in Forchheim, Germany, and his high school education at Semikler High School in İzmir. He graduated from Kafkas University Faculty of Veterinary Medicine in 1995. In 2003, he completed his Ph.D. in Biochemistry at the Institute of Health Sciences. He worked as an assistant professor in the Department of Biochemistry from 2004 to 2009. He earned the title of Associate Professor of Biochemistry in the field of Health Sciences in 2009. He was appointed Professor in 2014. He is currently working as a Professor in the Department of Biochemistry at Kafkas University Faculty of Medicine.

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