Open access peer-reviewed Edited Volume

Purinergic System

Margarete Dulce Bagatini

Universidade Federal da Fronteira Sul

Dr. Margarete Dulce Bagatini has a degree in Pharmacy and a Ph.D. in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee and a member of the Biovitta Research Institute


Ectonucleotidases E-NTPDase E-5'-Nucleotidase Nucleotides Adenosine Nucleosides Receptors - P1 P2 A1 A2 Purinergic System and Inflammation Cytokines

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About the book

Characterized by being a common signaling pathway between cells, the purinergic system is capable of modulating physiological and biochemical processes. Currently, it has been widely studied for its therapeutic potential and modulation of physiological processes, such as performance in the process of apoptosis, thromboregulation, cell proliferation, platelet aggregation, endothelial vasodilation, and pain mechanism, as well as neurotransmission and neuroprotection. In addition, promising studies also report an association of the purinergic system with inflammatory processes and immune responses. The purinergic system is defined as a set of components capable of generating a cellular intercommunication network. Composed of signaling molecules, regulatory enzymes and specific receptors, this organization is capable of modulating several basal pathways of the organism, however, its understanding is relatively recent for researchers. It is understood that purinergic signaling is present in all aspects of immunity and inflammation and, increasingly, studies show that extracellular ATP, together with its adenosine metabolite, are the main mediators of response. This occurs since most immune cells express P2 and P1 receptors, which are sensitive to the ATP and adenosine molecules, respectively. In addition, depending on the amount of ATP in the extracellular environment, this cotransmitter can act as an immunostimulant or immunodepressor, on the other hand, the concentration of adenosine has anti-inflammatory actions and is considered a potent immunosuppressive molecule.

The objective of this book is to describe the purinergic system, as well as the correlation between the system and the health and disease process.

Publishing process

Book initiated and editor appointed

Date completed: October 21st 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: December 23rd 2021

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Approved chapters written in full and submitted

Deadline for full chapters: February 21st 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 12th 2022

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Book compiled, published and promoted

Expected publication date: July 11th 2022

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About the editor

Margarete Dulce Bagatini

Universidade Federal da Fronteira Sul

Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee and a member of the Biovitta Research Institute. She is currently: the leader of the research group: Biological and Clinical Studies in Human Pathologies, professor of postgraduate program in Biochemistry at UFSC and postgraduate program in Science and Food Technology at UFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly on the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.

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Book chapters authored 2

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