Open access peer-reviewed Edited Volume

Endothelial Dysfunction - A Novel Paradigm

Alaeddin Abukabda

Lake Erie College of Osteopathic Medicine

A scientist who has been involved in the submission and writing of several National Institutes of Health (NIH) and National Science Foundation (NSF) grants. Dr. Abukabda is a member of many societies including the American Physiological Society and the American Association for the Advancement of Science.


Christopher Fonner

Lake Erie College of Osteopathic Medicine

Dr. Christopher Fonner is an assistant professor of physiology at the Lake Erie College of Osteopathic Medicine. He served as an advisor to several student organizations, including the Tri-Beta Biological Honors Society and the Health Professions Institute, among others.


Diabetes Mellitus Hypertension Rarefaction Oxidative Stress Nitric Oxide Endothelium Vascular Reactivity Microcirculation Circulation Vasomotion Blood Pressure Blood Flow

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About the book

The overarching scope of this book is aiming to provide a broad overview of the evolving foundational landscape regarding the function of this recently discovered cellular layer; the endothelial layer. Utilizing a step-up approach, the authors begin by describing the physiology of the endothelium and its importance as a regulatory hub for the maintenance of a constant cardiovascular and tissue environment. Mechanisms of endothelial dysfunction and its impact on cardiovascular homeostasis are presented to the reader in a clear and concise manner. Lastly, the relevance of the endothelium in the pathophysiology of highly relevant diseases including diabetes mellitus, hypertension, and metabolic syndrome are also approached. Book intends to provide the readers with chapters about understanding the intriguing role the endothelium plays in the normal function of the cardiovascular system.

Publishing process

Book initiated and editor appointed

Date completed: March 17th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: May 25th 2022

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: July 24th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: October 12th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: December 11th 2022

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About the editor

Alaeddin Abukabda

Lake Erie College of Osteopathic Medicine

Dr. Abukabda graduated from Al Fateh Dental College, Libya, in 2007. He obtained a master`s degree in Molecular Biology from Clarion University, Pennsylvania, in 2011. He later obtained a Ph.D. in Cellular Physiology from West Virginia University in 2018 and a Certification in Biostatistics from the West Virginia University School of Public Health. In 2018, Dr. Abukabda worked as a postdoctoral research associate at the Vascular Medicine Institute at the University of Pittsburgh. He has been involved in the submission and writing of several National Institutes of Health (NIH) and National Science Foundation (NSF) grants and intramural seed grants. Dr. Abukabda has published and presented many papers in immunology, toxicology, and cardiovascular physiology. He has also served as a reviewer for many journals in his field of expertise.

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