About the book
Since its initial isolation in 1934, hyaluronic acid (HA) has been studied extensively. HA is an unbranched glycosaminoglycan that consists of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid. It is a main component of articular cartilage where it has a critical role in maintaining cartilage homeostasis. HA is a contributor to many biological processes including cell signaling, wound repair, tissue regeneration and pathobiology. In addition to its bioactive properties, HA is a fascinating biomaterial. Key to its functionality, HA elicits unique physico-chemical properties such as biocompatibility, biodegradability, muco-adhesive and viscoelasticity. It is no wonder that HA has been extensively investigated as an integral cosmetic ingredient and active for treatment of joint disease. Advances in Hyaluronic Acid Based Therapy focuses on current applications with specific emphasis on anti-aging, osteoarthritis, tissue regeneration, natural and synthetic sources and methods of delivery. Both conventional and emerging methods for production of HA are explored. Examples of HA-based products are discussed and referenced throughout the book.