Open access peer-reviewed Edited Volume

3D Printing of Drugs

Marilena Vlachou

National and Kapodistrian University of Athens

Marilena Vlachou is an Assistant Professor who obtained her Pharmacy and Pharmaceutical Technology Ph.D. degrees from the National and Kapodistrian University of Athens and just prior to obtaining her Ph.D. she moved to the University of Rhode Island, United States, as a Visiting Research Scientist, she has over 100 publications.


3D Printing Technology Drug Delivery Systems Rapid QC Methods 3DP Drug Formulations Biopolymers Limitations Drug Carriers Chemometrics HPCL 3DP Processing New Techniques Personalized Medicines

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About the book

Three-dimensional printing (3DP) is an intriguing technique for fabricating a large variety of structures of objects, of diverse functions, by the sequential deposition of layers of materials. Using computer-aided design software, 3DP has found great potential in various areas, including biomedical and pharmaceutical applications, particularly for the development of patient-customized products. Within the pharmaceutical field, 3D printing can produce batches of medicinal products, of adequate size, with tailored dosages and release characteristics. To this end, different natural biopolymers, like gelatin, collagen, alginates, and chitosan have been utilised. Yet, they frequently necessitate cross-linkers, which could be cytotoxic, and therefore synthetic polymers have recently attracted attention for 3DP to avoid these disadvantages of natural polymers.

The fact that the products fabricated from 3 DP possess poor mechanical properties and anisotropic behaviour, creates a considerable hurdle in scale up. This is one of the challenges in 3 DP-based pharmaceutics production. Other challenges refer to the unsuitability of the commonly used polymers in 3 DP, with respect to thermolabile drug substances (API); this, however, can be circumvented by the preparation of a nanoformulation of the API before incorporation into the polymer.

The future perspectives of 3 DP products include the design of modern tools, like advanced chemometrically derived modeling for inducing fabrication speed and scaling up.

Publishing process

Book initiated and editor appointed

Date completed: August 26th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

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Approved chapters written in full and submitted

Deadline for full chapters: November 22nd 2020

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Full chapters peer reviewed

Review results due: February 10th 2021

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Expected publication date: April 11th 2021

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About the editor

Marilena Vlachou

National and Kapodistrian University of Athens

Marilena Vlachou is an Assistant Professor at the National and Kapodistrian University of Athens (NKUoA), Greece. She obtained her Pharmacy and PhD (Pharmaceutical Technology) degrees from the NKUoA. Just prior to obtaining her PhD she moved to the University of Rhode Island, United States, as a Visiting Research Scientist to conduct state-of-the art research on Pharmaceutical Technology techniques. Her research interests include: the formulation and in vitro release of bioactive substances from topical formulations; the efficacy and safety of formulations in skin disease therapies; the modified release of novel synthetic derivatives, with diverse activity; the investigation of the physicochemical properties of new excipients, including those of marine origin (Ulvans), and nanomaterials, with respect to their interaction with active pharmaceutical ingredients (APIs).

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Book chapters authored 2

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