About the book
This book intends to summarize and present comprehensively the latest advances in understanding of temperature regulation either at the level of the cell or at the level of tissue and central regulation by the hypothalamus. Specifically, we will aim to investigate the impact of temperature on mitochondrial and lysosomal function, as well as the delayed effects on protein expression and post-translational modifications. At the level of the tissue, we will aim to focus on the effect of temperature on inflammation and the specific effects on vascular permeability, chemokine production, and reactive oxygen species release and neutralization. Having assessed the pathophysiological significance of temperature alterations, we intend to present the clinical effects of temperature alterations in human disease, with the greatest focus on cardiovascular and neurological disease. Lastly, we will aim to assess the current clinical applications of targeted temperature management, discuss the differences between the experimental and clinical methodologies and assess the future of the field in the context of biomedical technology improvement and concomitant increased capacity to regulate heat exchange.