Open access peer-reviewed Edited Volume

Hypothermia and Hyperthermia - Physiology Concepts and Clinical Applications

Marinos Kosmopoulos

University of Minnesota Medical School

Dr. Marinos Kosmopoulos is an Internal medicine resident at the University of Minnesota Medical school, an active researcher in the fields of cardiology and resuscitation. He has participated in many cardiopulmonary resuscitations (CPR) translational research projects.


Hypothalamus Metabolism Thyroid Gland Heat Shock Protein OHCA Brain Porcine Models ECMO Resuscitation CABG Congenital Heart Disease Perfusion

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About the book

This book intends to summarize and present comprehensively the latest advances in understanding of temperature regulation either at the level of the cell or at the level of tissue and central regulation by the hypothalamus. Specifically, we will aim to investigate the impact of temperature on mitochondrial and lysosomal function, as well as the delayed effects on protein expression and post-translational modifications. At the level of the tissue, we will aim to focus on the effect of temperature on inflammation and the specific effects on vascular permeability, chemokine production, and reactive oxygen species release and neutralization. Having assessed the pathophysiological significance of temperature alterations, we intend to present the clinical effects of temperature alterations in human disease, with the greatest focus on cardiovascular and neurological disease. Lastly, we will aim to assess the current clinical applications of targeted temperature management, discuss the differences between the experimental and clinical methodologies and assess the future of the field in the context of biomedical technology improvement and concomitant increased capacity to regulate heat exchange.

Publishing process

Book initiated and editor appointed

Date completed: March 4th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: July 5th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: September 23rd 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: November 22nd 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Marinos Kosmopoulos

University of Minnesota Medical School

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