About the book
Heterocycles are found in nature and signify life due to innate structural subunits existence in many natural products, viz. vitamins, hormones, and antibiotics. Therefore, a considerable attention in the designing of biologically active molecules and in advanced drug industries is needed. Aromatic organic skeleton containing six-membered heterocyclics with two nitrogen at 1 & 3 positions in the ring which also belongs to one of the three diazines family, is more vulnerable in nucleic acids/nucleobases viz. cytosine (C), thymine (T), and uracil (U). This moiety owes resistivity to many microbes.
Substantial inventory research and developments are done in developing pyrimidine based drugs/API. Structurally modified pyrimidine moiety derived antimicrobials that have extended the lifespan of antifungals like azoles, antivirals as nonnucleoside reverse inhibitors, antibacterials β-lactams and quinolones. Thus many pharmaceutic industries have focused efforts on improving antimicrobials in established pyrimidine derivatives in response to antimicrobial resistance with multitasking portfolio of chemotherapeutics alterations. It is essential to develop novel drugs that work on different target sites as derived through pyrimidine derivatives.
This book will focus on significant pyrimidine derivatives in microbial and industrial world of antimicrobial agents along with clinical utilities. This is an overview of pyrimidine and its various derivatives with different mono-, di-, tri-, and tetrasubstituted classes along with in vitro antimicrobial activities.