Open access peer-reviewed Edited Volume

Pyrimidine and its Derivatives

Rajendra Dongre

RTM Nagpur University


chemoinformatics POM-combinatorial analysis QSAR pyrimidines antibacterials drug score index POM combinatorial analysis gram positive gram negative bacteria pharmacophore site evaluated in continuation of POM investigation antimicrobial activity naturally occurring pyrimidine as antimicrobial mono- di- tri- & tetrasubstituted derivatives pyrimidine in synthetic products as antimicrobial

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About the book

Heterocycles are found in nature and signify life due to innate structural subunits existence in many natural products, viz. vitamins, hormones, and antibiotics. Therefore, a considerable attention in the designing of biologically active molecules and in advanced drug industries is needed. Aromatic organic skeleton containing six-membered heterocyclics with two nitrogen at 1 & 3 positions in the ring which also belongs to one of the three diazines family, is more vulnerable in nucleic acids/nucleobases viz. cytosine (C), thymine (T), and uracil (U). This moiety owes resistivity to many microbes.

Substantial inventory research and developments are done in developing pyrimidine based drugs/API. Structurally modified pyrimidine moiety derived antimicrobials that have extended the lifespan of antifungals like azoles, antivirals as nonnucleoside reverse inhibitors, antibacterials β-lactams and quinolones. Thus many pharmaceutic industries have focused efforts on improving antimicrobials in established pyrimidine derivatives in response to antimicrobial resistance with multitasking portfolio of chemotherapeutics alterations. It is essential to develop novel drugs that work on different target sites as derived through pyrimidine derivatives.

This book will focus on significant pyrimidine derivatives in microbial and industrial world of antimicrobial agents along with clinical utilities. This is an overview of pyrimidine and its various derivatives with different mono-, di-, tri-, and tetrasubstituted classes along with in vitro antimicrobial activities.

Publishing process

Book initiated and editor appointed

Date completed: October 18th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: January 7th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 27th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 26th 2020

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About the editor

Rajendra Dongre

RTM Nagpur University

Rajendra S. Dongre M.Sc. from Department of Chemistry, R.T.M., Nagpur University in 1996 (Gold Medalist) and Ph.D. in 2010. Research work on organic synthesis, chitosan bio-composites, matrixes and remediation of water pollution de-fluoridation, nitrate, chromium, phosphate lead (II). Worked as Scientists-B in CSIR-LAB, National Environmental Engineering Research Institute (NEERI) Nagpur M.S., India. Overall 25 years of experience in R&D and 17 years of post graduate teaching experience which resulted in fifty five international/national research publications. Also guided four Ph.D. research students. Received 6th National Award (Runner Up position) for Technology Innovation in Petrochemicals and Downstream Plastics Processing Industry, for the research in the field of polymer science & technology handed by Hon’ble Ananth Kumar, Petrochemical & Fertilizers Minister of Government of India in 2016. Received 5th National Science & Technology Award for research contribution in the field of developing science in 2017, by EET-CRS, Noida, India.

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Book chapters authored 6

Books edited 1

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