\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5703",leadTitle:null,fullTitle:"Electrical Resistivity and Conductivity",title:"Electrical Resistivity and Conductivity",subtitle:null,reviewType:"peer-reviewed",abstract:'Motivated by the importance of electrical resistivity and conductivity, important experts in this field grasp most recent researches in this book. It addresses recent advances in electrical resistivity and conductivity modelling, measurement, estimation and sensing methods and implications. This book introduces innovative case studies for "Electrical Resistivity Sensing Methods and Implications", "Resistivity Model of Frozen Soil and High-Density Resistivity Method for Exploration of Discontinuous Permafrost", "Measurement of Electrical Resistivity for Unconventional Structures", "Estimation of Hydrological Parameters from Geoelectric Measurements" and "Assessment of Cryoprotectant Concentration by Electrical Conductivity Measurement and Its Applications in Cryopreservation". These recent advances are well prepared and presented in six chapters. These chapters are carefully selected to reflect current variable techniques, new concepts and methods related to the book\'s topic from different perspectives.',isbn:"978-953-51-3186-1",printIsbn:"978-953-51-3185-4",pdfIsbn:"978-953-51-4815-9",doi:"10.5772/65130",price:119,priceEur:129,priceUsd:155,slug:"electrical-resistivity-and-conductivity",numberOfPages:124,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"1610778635f74a85054885a032a5554a",bookSignature:"Adel El Shahat",publishedDate:"May 31st 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5703.jpg",numberOfDownloads:9822,numberOfWosCitations:16,numberOfCrossrefCitations:9,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:21,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:46,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 29th 2016",dateEndSecondStepPublish:"September 19th 2016",dateEndThirdStepPublish:"December 16th 2016",dateEndFourthStepPublish:"March 16th 2017",dateEndFifthStepPublish:"May 15th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"193331",title:"Dr.",name:"Adel",middleName:null,surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat",profilePictureURL:"https://mts.intechopen.com/storage/users/193331/images/system/193331.jpg",biography:"Dr. Adel El-Shahat received a B.Sc. in Electrical Engineering from Zagazig University, Egypt, in 1999. the M.Sc. in Electrical Engineering (Power and Machines) from Zagazig University, Egypt, in 2004, and the Ph.D. degree (Joint Supervision) from Zagazig University, Egypt, and The Ohio State University (OSU), Columbus, OH, USA, in 2011. He is currently an Assistant Professor - Energy Technology, School of Engineering Technology at Purdue University, USA. He is the Founder and Director of Advanced Power Units and Renewable Distributed Energy Lab (A_PURDUE). His research focuses on Modeling, Design, Multi-Objectives Optimization, Simulation, Analysis, and Control of various aspects such as Smart Nano & Micro- Grids; Electric Mobility & Transportation Electrification, Renewable Energy Systems; Wireless Charging of Electric Vehicles; Electric Vehicles; Special Purposes Electric Machines; Deep Learning Techniques; Distributed Generation Systems; Thermoelectric Generation; Special Power Electronics Converters; Power Systems; Energy Storage & Conservation; and Engineering Education. So far, He has 9 books, 5 chapters in books, 63 journal papers, 73 conference papers, and 106 other publications with his collaborators, and students related to his research interests. He has more than 20 years of working experience in academia and industry. He has experience in funding grant proposals, and He got some awards and recognitions due to his research work. He has good experience directing research for both graduate and undergraduate students for funded projects. He holds full-time academic positions at Purdue University, Georgia Southern University, the University of Illinois at Chicago, Ohio State University, USA, and Suez University, Egypt, along with some full-time and part-time positions in Egyptian companies as an electrical engineer, and consultant as a professional engineer. Additionally, He has distinguished professional training, and He is a Senior Member in the IEEE and IRED institutions along with 21 professional memberships in other societies. Finally, He served as a book editor for 4 books, and a reviewer for 8 books. He is a guest editor and editor-in-chief for three international journals. Also, He is a reviewer for other 35 international journals. Moreover, He served as invited conference sessions chair and reviewer for 31 international conferences along with other community and academic services.",institutionString:"Georgia Southern University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Purdue University West Lafayette",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"756",title:"Power Electronics",slug:"power-electronics"}],chapters:[{id:"55295",title:"Introductory Chapter: Recent Advances",doi:"10.5772/intechopen.69046",slug:"introductory-chapter-recent-advances",totalDownloads:1291,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Adel El-Shahat",downloadPdfUrl:"/chapter/pdf-download/55295",previewPdfUrl:"/chapter/pdf-preview/55295",authors:[{id:"193331",title:"Dr.",name:"Adel",surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat"}],corrections:null},{id:"54410",title:"Electrical Resistivity Sensing Methods and Implications",doi:"10.5772/67748",slug:"electrical-resistivity-sensing-methods-and-implications",totalDownloads:1686,totalCrossrefCites:5,totalDimensionsCites:12,hasAltmetrics:1,abstract:"This chapter discusses and explains the basic operating principles of various measuring methods of resistivity for materials in both liquid and solid phase. It provides explanations for two-, three-, and four-pole as well as toroidal resistivity cells. The van der Pauw technique is explored as a step-by-step procedure to estimate the resistivity of a material with no arbitrary shape. The special case of sheet material resistivity and resistance is explained in more detail, and equation for that special problem is simplified. It further provides information on common experimental errors and a short guideline to improve the reliability and accuracy of the measurements. The implications and challenges faced during resistivity measurements are explored and explained with ways to compensate for errors due to temperature and capacitance changes. In addition, the way to experimentally determine the cell constant of a cell is described and the necessity for calibration is clearly explained. It further provides information to overcome the standard problem of polarisation when the resistivity of solutions with high ionic content is investigated.",signatures:"Marios Sophocleous",downloadPdfUrl:"/chapter/pdf-download/54410",previewPdfUrl:"/chapter/pdf-preview/54410",authors:[{id:"195268",title:"Dr.",name:"Marios",surname:"Sophocleous",slug:"marios-sophocleous",fullName:"Marios Sophocleous"}],corrections:null},{id:"54869",title:"Resistivity Model of Frozen Soil and High‐Density Resistivity Method for Exploration Discontinuous Permafrost",doi:"10.5772/intechopen.68197",slug:"resistivity-model-of-frozen-soil-and-high-density-resistivity-method-for-exploration-discontinuous-p",totalDownloads:1759,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:"In permafrost‐degraded areas, “islands” of permafrost can be buried in the unfrozen soil. When permafrost is arranged in this discontinuous pattern, it is more difficult to analyze from an engineering or geological perspective. The degree of resistivity of unfrozen soil is determined by the dry density, temperature, moisture content, and pore water resistivity of the soil, as well as by the mineral composition, size, and cementing state of the soil particles. Part of the water in the soil pores experiences a phase change as the soil freezes, so permafrost has different resistivity than unfrozen soil. In this chapter, we explore the conduction characteristics of permafrost. First, we established a theoretical model to analyze the factors affecting the resistivity of permafrost. Next, we used an experimental study to analyze how unfrozen water content, initial moisture content, soil temperature, and dry density influence the resistivity of frozen soil. These experimental study results served to validate the rationality of the model of permafrost resistivity. To analyze differences in conductivity between underground media, we used a high‐density resistivity (HDR) method, which infers the storage of underground geologic bodies with different resistivity based on the distribution of a conduction current under the electric field action. In this chapter, the WGMD‐9 super HDR measurement system produced by the Chongqing Benteng Numerical Control Technique Research Institute was used to obtain the resistivity profile. The study region was the road area from Bei’an Expressway to Heihe Expressway in the permafrost degeneration area in Northeast China. A permafrost profile map was drawn based on data from engineering drilling and an analysis of factors that influence permafrost resistivity. The reliability of the permafrost profile map was verified by an analysis of temperature data taken at measured points at different depths of the soil profile.",signatures:"Wei Shan, Zhaoguang Hu, Ying Guo, Chengcheng Zhang and Yao\nLiu",downloadPdfUrl:"/chapter/pdf-download/54869",previewPdfUrl:"/chapter/pdf-preview/54869",authors:[{id:"139091",title:"Dr.",name:"Wei",surname:"Shan",slug:"wei-shan",fullName:"Wei Shan"},{id:"162871",title:"Dr.",name:"Ying",surname:"Guo",slug:"ying-guo",fullName:"Ying Guo"},{id:"184953",title:"Mr.",name:"Zhaoguang",surname:"Hu",slug:"zhaoguang-hu",fullName:"Zhaoguang Hu"},{id:"204567",title:"Dr.",name:"Chengcheng",surname:"Zhang",slug:"chengcheng-zhang",fullName:"Chengcheng Zhang"},{id:"204568",title:"Dr.",name:"Yao",surname:"Liu",slug:"yao-liu",fullName:"Yao Liu"}],corrections:null},{id:"54627",title:"Measurement of the Electrical Resistivity for Unconventional Structures",doi:"10.5772/67854",slug:"measurement-of-the-electrical-resistivity-for-unconventional-structures",totalDownloads:1670,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This study presents an apparatus for the measurement of the electrical volume resistivity of concrete structures in civil and industrial constructions in 2.5 accuracy class, which operates at 500 Hz, for measuring the in situ resistivity of concrete in the range of 5–100 Ωm that is immune to errors due to the polarization phenomena at the interface probe/concrete sample. Also, a quench protection active system (QPS), which works in tandem with a superconducting coil structures (SCSs), in order to prevent the damaging effects when the coil structures pass from the superconducting state into normal conduction state (quench), is presented. An SCS made of YBCO tape high‐temperature superconductor (HTS) type, with a critical temperature of 92 K, has been experimented. In order to minimize the heat transfer influx by convection, the SCSs are confined to a cryostat, which is vacuumed at about 0.001 mbar. The working temperature of the HTS coil structures is about 77 K, ensured by liquid nitrogen as cryogenic agent. Finally, the measurement of the electrical resistance of the sensing element (SE) as part of the resistive‐type gas sensor is shown. The SE is placed on a Wheatstone bridge. The electrical resistance of the SE is variable by an amount ΔR, on when all the resistances of a Wheatstone bridge are nominally equal.",signatures:"Lucian Pîslaru‐Dănescu and Lipan Laurențiu Constantin",downloadPdfUrl:"/chapter/pdf-download/54627",previewPdfUrl:"/chapter/pdf-preview/54627",authors:[{id:"187612",title:"Dr.",name:"Lucian",surname:"Pîslaru-Dănescu",slug:"lucian-pislaru-danescu",fullName:"Lucian Pîslaru-Dănescu"},{id:"196151",title:"Dr.",name:"Laurentiu Constantin",surname:"Lipan",slug:"laurentiu-constantin-lipan",fullName:"Laurentiu Constantin Lipan"}],corrections:null},{id:"54740",title:"Estimation of Hydrological Parameters from Geoelectrical Measurements",doi:"10.5772/67990",slug:"estimation-of-hydrological-parameters-from-geoelectrical-measurements",totalDownloads:2036,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:1,abstract:"In the coastal aquifer of the lowlands on the right side of the river Sinaloa there is need for fresh water for agricultural development since, around 15% of the water used in agricultural irrigation, is from underground sources. This situation is exacerbated in periods of drought, which promotes drilling with the risk of finding brackish water in them; besides, there is the risk of not meeting water demand due to low hydraulic transmissivity (T) of the aquifer, putting at risk the drilling costs that this implies. In this sense, the determination of T and K (hydraulic conductivity) is important for the development and management of groundwater exploitation of the study area. Generally by means of pumping tests in wells, T is obtained, with high costs, so there are few values of T. K is generally obtained by wells and laboratory test. The aim of this chapter is to establish an empirical relationship between T and K with Dar-Zarrouk parameter in porous media, transverse resistance (T\nR\n), in addition to a characterization of the water quality through the electrical resistivity. This parameter is estimated from surface resistivity measurements, which are more economical in relation to the pumping tests; thus, T was characterized in the study area. The coefficient of correlation of the exponential adjustment is 0.79 and the relation is T=137185.7 TR0.020758−156691 and K=367.210.0548−518.813 with coefficient of correlation of 0.678.",signatures:"Héctor José Peinado Guevara, Jaime Herrera Barrientos, Omar\nDelgado Rodríguez, Víctor Manuel Peinado Guevara, Omar Llanes\nCárdenas and María Ladrón De Guevara Torres",downloadPdfUrl:"/chapter/pdf-download/54740",previewPdfUrl:"/chapter/pdf-preview/54740",authors:[{id:"36734",title:"Dr.",name:"Héctor José",surname:"Peinado-Guevara",slug:"hector-jose-peinado-guevara",fullName:"Héctor José Peinado-Guevara"},{id:"196347",title:"Dr.",name:"Jaime",surname:"Herrera Barrientos",slug:"jaime-herrera-barrientos",fullName:"Jaime Herrera Barrientos"},{id:"196348",title:"Dr.",name:"Omar",surname:"Delgado Rodríguez",slug:"omar-delgado-rodriguez",fullName:"Omar Delgado Rodríguez"},{id:"196349",title:"Dr.",name:"Víctor Manuel",surname:"Peinado Guevara",slug:"victor-manuel-peinado-guevara",fullName:"Víctor Manuel Peinado Guevara"},{id:"196350",title:"Ms.",name:"María",surname:"Ladrón De Guevara Torres",slug:"maria-ladron-de-guevara-torres",fullName:"María Ladrón De Guevara Torres"},{id:"205290",title:"Dr.",name:"Omar",surname:"Llanes Cardenas",slug:"omar-llanes-cardenas",fullName:"Omar Llanes Cardenas"}],corrections:null},{id:"54433",title:"Assessment of Cryoprotectant Concentration by Electrical Conductivity Measurement and Its Applications in Cryopreservation",doi:"10.5772/67747",slug:"assessment-of-cryoprotectant-concentration-by-electrical-conductivity-measurement-and-its-applicatio",totalDownloads:1380,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"This chapter presents an important application of the electrical conductivity measurement in cryopreservation. Long-term cryopreservation of cells and tissues is essential in both clinical treatments and fundamental researches. In order to reduce the cryo-injury to the cells during cryopreservation, cryoprotective agents (CPAs) should be added before freezing, but also removed after thawing duo to the cytotoxicity. In these steps, severe osmotic stresses may result in injuries to the cells too. Therefore, monitoring the addition and removal of CPAs to the cell samples is critical in order to prevent the osmotic injury. In this chapter, the electrical conductivity measurement was applied to assess the CPA concentration in cryopreservation. Firstly, the standard correlations between the CPA concentration and the electrical conductivity of the solutions (including CPA-NaCl-water ternary solutions and CPA-albumin-NaCl-water quaternary solutions) were experimentally obtained for a few mostly used CPAs. Then a novel ?dilution-filtration? system with hollow fiber dialyzer was designed and applied to remove the CPA from the solutions effectively. Measurement of electrical conductivity was validated as a safer and easier way to on-line and real-time monitoring of CPA concentration in cell suspensions. This work demonstrated a very important application of electrical conductivity in the biomedical engineering field.",signatures:"Zhiquan Shu, Hsiu-Hung Chen, Xiaoming Zhou and Dayong Gao",downloadPdfUrl:"/chapter/pdf-download/54433",previewPdfUrl:"/chapter/pdf-preview/54433",authors:[{id:"100298",title:"Prof.",name:"Dayong",surname:"Gao",slug:"dayong-gao",fullName:"Dayong Gao"},{id:"173780",title:"Dr.",name:"Zhiquan",surname:"Shu",slug:"zhiquan-shu",fullName:"Zhiquan Shu"},{id:"195682",title:"Dr.",name:"Hsiu-Hung",surname:"Chen",slug:"hsiu-hung-chen",fullName:"Hsiu-Hung Chen"},{id:"195683",title:"Dr.",name:"Xiaoming",surname:"Zhou",slug:"xiaoming-zhou",fullName:"Xiaoming Zhou"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7211",title:"Electric Machines for Smart Grids Applications",subtitle:"Design, Simulation and 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\r\n\tGenome-Wide Association Studies (GWAS) are analyzes of specific genetic variations throughout a genome to identify whether any variant is associated with a particular trait. in the post-genomic era, there is an immense amount of data regarding the genome of countless organisms. This enormous availability of genomic information, in addition to its data availability, enables analysis of the complete genome of the species and imposes a growing demand for the understanding of several complex biological phenomena. Initially, the GWAS approach was applied in human genome studies involving entire sets of DNA from numerous individuals to find gene variations related to diseases such as asthma, diabetes, cancers, heart disease, and mental disorders. Nowadays the impact of GWS studies is not restricted only to the human genome to advances in the understanding of diseases. With the genome sequencing of several species and the availability of their complete genomes in large databases, other complex aspects can be investigated today by GWAS, such as evolutionary and phylogenetic relationships, characteristics of relevance for biodiversity conservation, and genetic improvement of plants and animals. Included in this book there are original and relevant works involving GWAS studies, carefully selected for the academic public. This book has been carefully designed to provide current and quality information to students and researchers of all levels who have an interest in Genome-Wide Association Studies and its applications.
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Academic editor of books and journals and author of 3 patents and 1 software registration. Dr. Rafael Trindade Maia received a master´s degree in Genetics, Conservation, and Evolutionary Biology from the National Institute of Amazonian Research, Brazil, in 2008, and a Ph.D. in Animal Biology from the Federal University of Pernambuco, Brazil, in 2013.",coeditorOneBiosketch:"Dr. Magnólia A. Campos is a researcher with experience in the Genetics and Plant genomics and the author of books and patents. She has a master's in Agronomy / Plant Breeding from the Federal University of Pelotas and a Ph.D. in Biological Sciences / Molecular Biology from the University of Brasília. 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He is currently an adjunct professor at the Center for the Sustainable Development for Semiarid (CDSA) at Federal University of Campina Grande (UFCG), Brazil. He has experience with population genetics, bioinformatics, molecular docking, and modeling and molecular dynamics of proteins. He works in science and biology education. 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She has experience in the area of plant biotechnology, working mainly on the following topics: genomics, bioinformatics, tissue culture and plant cells, genetic transformation of plants, study of gene expression during plant-microbe interactions and expression of heterologous proteins in bacteria.",institutionString:"Federal University of Campina Grande",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Federal University of Campina Grande",institutionURL:null,country:{name:"Brazil"}}},coeditorTwo:{id:"468502",title:"Dr.",name:"Marco Antônio",middleName:null,surname:"Alves Schetino",slug:"marco-antonio-alves-schetino",fullName:"Marco Antônio Alves Schetino",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Dr. Marco Antônio Alves Schetino studied biological sciences at the Federal University of Viçosa (UFV), Brazil (2005), received a master´s degree in Genetics, Conservation, and Evolutionary Biology from the National Institute of Amazonian Research (INPA), Brazil, in 2008, and a Ph.D. in Genetics from the Federal University of Minas Gerais (UFMG), Brazil, in 2017. 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The physics of the system dictates that excitons must dissociate efficiently at a donor-acceptor interface, and that sufficient pathways for charge transport to the electrodes are also required. Conjugated polymer crystals are considered to be the primary hole carrier and thus are essential for effective charge transport. With this in mind, the ideal morphology for an organic photovoltaic BHJ film was often considered until a few years ago to be a bicontinuous, interpenetrating network morphology composed of pure P3HT and pure PCBM phases, with both phases of order ∼20 nm in size [5, 6] and numerous cartoon depictions have helped to propagate this view, as the one shown in Figure 1.
\n\t\t\tIn this idealized model, the two pure phases of donor and acceptor within the bulk heterojunction are interdigitated in percolated highways with an average length scale of around 10-20 nm, equal to or less than the exciton diffusion length, to ensure exciton dissociation and high mobility charge carrier transport with reduced recombination. Furthermore, a pure donor phase at the hole collecting electrode and a pure acceptor phase at the electron collecting electrodes should exist in order to minimize the losses by recombination of opposite charges or acting as diffusion barriers for the opposite sign charge carriers at the respective electrodes. The presence of mixed phases in these BHJ were considered to be counterproductive to device performance, since isolated molecules could act as traps for separated charges and centers for charge recombination within the percolation pathways.
\n\t\t\tMany efforts have used this ideal model to design studies that examine the effect of the chemical structure of conjugated polymer, composition, and processing methods on the ability to achieve this ideal interpenetrating two-phase system [1]. Furthermore, when describing the device physics of such organic photovoltaic devices, theoretical models have been developed which mainly relied on the assumption that the components existed as two separated pure phases [7-10].
\n\t\t\tThe ideal structure of a bulk heterojunction solar cell as represented by Sariciftci
Experimentally, although several different techniques have been used to study the morphology of these systems, part of the difficulties in the past in determining the precise composition of phases, interfacial structure, and morphology of bulk heterojunctions has been the limitations of contrast between the phases. For instance in standard electron-based techniques, crystalline P3HT and PCBM offer sufficient contrast between those two phases; however their amorphous counterparts are almost indistinguishable. Consequently conventional x-ray diffraction methods are unable to probe the amorphous regions in these conjugated polymer-fullerene mixtures. On the other hand, AFM techniques only allow the study of the morphology of surfaces and this might be very different from the morphology of the underlying bulk of the film. Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) have also been used but they can only provide indirect information about the morphology of these BHJ. For these reasons, more recently neutron and soft x-ray scattering techniques have started being used to provide heretofore unavailable information concerning the bulk morphology of these bulk heterojunctions. Additionally techniques utilizing specific atomic or group specific contrast such as secondary ion mass spectroscopy (SIMS) have added further information to the growing wealth of morphological information about BHJs. One clear advantage on the use of neutrons lies in the fact that for instance in the case of P3HT/PCBM systems, the scattering length density (SLD) difference between P3HT (0.83x10-6 Å-2) and PCBM (4.3x10-6 Å-2) is sufficiently high, and no additional deuteration of one component is necessary.
\n\t\t\tOver approximately the last five years a reinterpretation of the existing idealized model has lead to a new understanding on the thermodynamics and the morphology of these bulk heterojunction systems. This chapter reviews some of the relevant literature relating to this new emerging understanding with concentration on the system of P3HT and PCBM, which has been the most widely studied OPV system to date.
\n\t\tUntil a few years ago, the conventional wisdom was that the most widely studied OPV system of P3HT:PCBM was a simple two phase bulk heterojunction with well-defined interfaces between regions of approximately pure P3HT and pure PCBM. Then, from 2008 onwards several works in the literature began to show that this model was deficient in a number of ways since it did not account for the phase behavior of the mixtures or explain what the interface was between the phases or the two electrode interfaces. However, the results reported are often contradictory or conflicting as explained below.
\n\t\t\tOne of the early studies to refute the concept of simple pure two phase behavior in BHJ systems was made by Muller
Additional studies by Kim
A further measurement of the phase diagram of P3HT:PCBM blends was made by Zhao
Phase diagrams of the system P3HT:PCBM as reported by Muller
Hopkinson
The effects of polymer crystallinity on miscibility have also been studied for P3HT and MDMO-PPV blended with PCBM by Collins
Miscibility phase diagram for P3HT mixed with PCBM according with Collins
Small-angle neutron scattering (SANS) studies on 1:1 P3HT:PCBM blend thin films by Kiel
Recently, Kozub
where Tm is the melting point at a solvent (i.e. PCBM) volume fraction
Small-angle x-ray scattering (SAXS) studies of the phase separation of P3HT-PCBM thick films showed that a bulk heterojunction system blend of 1:0.7 P3HT:PCBM is not just a simple two-phase system with well-defined interfaces [20]. As other workers have shown the phase behavior was shown to be a much more complicated system incorporating regions of crystalline P3HT and PCBM, and a mixed phase of amorphous P3HT and PCBM. The phase separation length scale was found to be ∼25 nm both before and after thermal annealing. The thermal annealing was also shown to cause a reduction in the phase separation associated with diffusion of PCBM into the amorphous P3HT, as previously also reported by Kiel
The influence played by the electrode interfaces on BHJ phase behavior has been studied by Chen
Yin
Estimate of the miscibility from measurements of the melting point depression, as described by Kozub
Treat
A direct comparison between conventionally prepared P3HT/PCBM BHJs (C-BHJ) and an active layer created by solution processed, layer-by-layer, sequential deposition (layer evolved BHJ, LE-BHJ) has been studied by Moon
A systematic study to understand how the P3HT molecular weight influences the P3HT/PCBM phase behavior and the corresponding device performance has been undertaken by Nicolet
Molecular mixing in P3HT/PCBM thin films annealed at 140ºC was also the focus of a grazing incidence small-angle neutron scattering (GISANS) study by Ruderer
As discussed above, the thermodynamics and phase behavior of conjugated polymer/fullerene systems is very complex and except in specific examples (such as P3HT/PCBM) it is still poorly understood. Even in the highly studied example of P3HT/PCBM there are conflicting results about the phase behavior. For example while some consider that these systems have an eutectic type of phase behavior [11-13] (as is usually found in metal mixtures and salt mixtures), others [19] are more in favor of the classical Flory-Huggins phase behavior common in amorphous polymer systems [27]. There is also disagreement in the P3HT/PCBM miscibility limits (i.e. in the amount of molecularly dispersed PCBM in the P3HT phase) reported in the literature. For instance, while Kozub
In most of the studies described above, the main focus has been the study of the thermodynamics of the bulk and therefore the experimental samples were thick enough to avoid any relevant effect from the substrate’s surface energy. It is however known that in very thin polymer films (~100 nm) as used in OPVs, the thin film morphology and phase behavior is also affected by the substrate’s surface energy. This phenomenon has also been the object of intense research and it is known that the substrate’s free energy can induce vertical phase segregation (normal to the substrate’s surface). However, just like reports of bulk BHJ behavior there are also contradictory reports in the literature concerning the effect of the substrate’s surface energy on the final film morphology.
\n\t\t\ta) Distances (structure size) and small (object radius) and large PCBM domains (domain radius) used for the simulations of the GISANS data depending on the PCBM content [
The compositional depth profiles in thin films of APFO-3:PCBM blends spin-coated from chloroform solutions onto silicon has been studied by Björström
Vertical segregation behavior in P3HT:PCBM (1:1) blend films were also studied by Kim
The importance of film thickness has been investigated by Verploegen
Further NR studies of morphology of the P3HT:PCBM thin films either freshly cast, or after solvent and thermally annealing have been made by Parnell
The use of ToF-SIMS has been able to add to the morphological model derived by NR measurements by examining both the vertical as well as the lateral distribution of PCBM and P3HT in BHJ films [35]. In 150 nm thick films spun coated from a 1:1 weight ratio of P3HT:PCBM chlorobenzene solutions, ToF-SIMS imaging showed that the lateral phase separation (within the limit of the micron resolution of SIMS imaging) was similar before and after an annealing treatment at 140ºC for 30 min. However, depth profiling clearly shows a vertical phase separation of P3HT:PCBM on the pristine blend (before annealing), with a higher concentration of PCBM close to the PEDOT:PSS interface. On the other hand, after annealing, the cross-sectional images of PCBM and P3HT are both uniform along the vertical axis showing that the annealing treatment suppresses the vertical phase segregation. Using low voltage, high resolution TEM, Beal
Xue
Theoretical descriptions indicate a segregation preference for a typical photovoltaic device is where the donor (P3HT) is concentrated close to the substrate, and the acceptor (PCBM) next to the top surface, onto which the cathode (for example Al) is deposited. This distribution of components is expected to enhance the selectivity of the contacts towards one type of charge carrier and so reduce charge leakage. As discussed above, there are clearly contradictory results in the experimental literature concerning the exact nature of this vertical phase segregation. However, there is agreement that annealing leads to an increase of the PCBM concentration closer to the cathode [30, 33-35], and this has been pointed out as being one of the reasons for the improvement of device efficiencies that is usually observed upon annealing treatments. The timing of the annealing process, i.e. before or after the deposition of a metal electrode, is also known to influence the results. Post-production thermal annealing can improve the evolution of well-ordered nanoscale morphology because of a limitation of PCBM overgrowth, that is, due to the confinement effect.
\n\t\tAs shown in Figure 2, Muller
The effect of drying kinetics on the resultant P3HT:PCBM blend has a profound effect on the final device characteristics [38], where it was found that films dried slowly had better performance characteristics (higher external quantum efficiency, higher power conversion efficiency, higher fill factor, and lower series resistance) than the rapidly dried films. The charge carrier mobility of holes and electrons in P3HT:PCBM thick films was shown to have more balanced transport properties and non-dispersive dynamics for the slowly dried films, where as the rapidly dried film displayed dispersive dynamics and unbalanced transport. All these differences in performance were explained by the rate of solvent evaporation, as fast solvent loss quenches the phase separation process, and conversely the longer the blend is mobile and contains solvent the more the mixture will proceed to a more phase separated state. Campoy-Quiles
The time-dependent morphology evolution of blend films of P3HT and PCBM, was investigated by Jo
The reasons for the irreproducibility of the performance of P3HT:PCBM BHJ solar cells fabricated using nominally identical conditions has been investigated by de Villers
Wang
The rate of evaporation is clearly affected by the boiling point and vapor pressure of the solvents used. The influence solvent boiling point on the morphology and photovoltaic performance of P3HT:PCBMBHJ films produced via spin-coating, has been studied by Ruderer
Schmidt-Hansberg
a) Schematic of the experimental setup for simultaneous real time GIXD and laser reflectometry of doctor-bladed thin films in a controlled drying environment. (b) Schematic of P3HT unit cell. (c) Ternary phase diagram of P3HT-PCBM-DCB; the star symbols denote phase transitions in the binary cases. From reference [
Sobkowicz
The rate of cooling, after annealing, also has a dramatic influence on the final morphology of the film. A slower cooling rate leads to a greater extent of crystallization, when semi-crystalline polymers or crystalline nano-particles are involved. Despite this fact, only recently have some authors drawn attention to this important factor [37].
\n\t\tRecent detailed studies of the phase behavior of conjugated polymer:fullerene blends have begun to provide important information for understanding the property-processing relationships in organic solar cell blends. Until these studies conventional wisdom suggested that the P3HT:PCBM system was a simple two phase bulk heterojunction with well-defined interfaces between regions of pure P3HT and pure PCBM. The latest results clearly demonstrate that this assumption is not correct, but instead unequivocally show that BHJ materials are more complex systems incorporating regions of crystalline P3HT, PCBM, and intermixed regions of amorphous P3HT and PCBM. Upon annealing there is considerable interdiffusion of PCBM into the amorphous P3HT. It has also been shown that in the case of thin BHJ films (~100 nm) such as those used in OPVs, the substrate’s surface energy can have a crucial role on the final morphology.
\n\t\t\tFurthermore, the kinetics as manifested in the processing routes and conditions can also play a dominant role in the observed structure/morphology. For all these reasons it is very difficult to predict the structure of the BHJ since apparently the same process used by different groups can end to with different results.
\n\t\t\tWhilst significant insight has been derived in understanding the behavior of a limited number of systems, with P3HT:PCBM the most widely studied system by far, there is still no predictive understanding in even this system. If technologically meaningful device efficiencies are to be achieved significant additional work must be undertaken to derive predictive capability for these complex BHJ systems. This will ultimately require a global effort of complementary experimental measurements combined with theoretical and computational modeling.
\n\t\tAFM – Atomic Force Microscopy
\n\t\t\tBHJ – Bulk Hetero-Junction
\n\t\t\tDMTA – Dynamic Mechanical Thermal Analysis
\n\t\t\tGISANS - Grazing Incidence Small-Angle Neutron Scattering
\n\t\t\tGIXS – Grazing Incidence X-ray Scattering
\n\t\t\tGIWAXS/GIXD – Grazing Incidence Wide-Angle X-ray Scattering/x-ray diffraction
\n\t\t\tITO – Indium Tin Oxide
\n\t\t\tMEH-PPV - poly [2-methoxy-5-(2-ethyl-hexyloxy)-1,4-phenylene-vinylene]
\n\t\t\tMDMO-PPV – poly(2-methoxy-5-(3’,7’-dimethyloctyloxy)-1,4-phenylenevinylene)
\n\t\t\tNEXAFS – Near-Edge X-ray Absorption Fine Structure
\n\t\t\tNR – Neutron Reflectivity
\n\t\t\tOPV – Organic Photo-Voltaic
\n\t\t\tP3HT – poly(3-hexylthiophene)
\n\t\t\tPCBM – phenyl-C61-butyric acid methyl ester
\n\t\t\tPEDOT:PSS – Poly(3,4-EthyleneDiOxyThiophene):Poly(StyreneSulfonate)
\n\t\t\tSANS – Small Angle Neutron Scattering
\n\t\t\tSAXS – Small-Angle X-ray Scattering
\n\t\t\tSIMS – Secondary Ion Mass Spectrometry
\n\t\t\tTEM – Transmission Electron Microscopy
\n\t\t\tToF-SIMS – Time-of-Flight Secondary Ion Mass Spectrometry
\n\t\t\tUCST – Upper Critical Solubility Temperature
\n\t\t\tUV-Vis – Ultra-Violet Visible
\n\t\t\tXRD – X-ray diffraction
\n\t\t\tWAXS – Wide-Angle X-ray Scattering
\n\t\tGabriel Bernardo acknowledges financial support from the IPC\'s (Institute for Polymers and Composites) strategic project: "PEst-C/CTM/LA0025/2011" (Projecto Estratégico—LA 25—2011-2012—Strategic Project—LA 25—2011-2012).
Chronic migraine (CM) is defined as the occurrence of headache for at least 8 migraine days in a month and at least 15 headache days in the same month [1], being much less common and more debilitating than episodic migraine. Evidence indicates that migraine is a progressive disorder [2, 3, 4], and therefore, diagnosis and early management of episodic migraine are recommended, in order to avoid its chronicity, especially in adolescents; however, there is a failure in the accuracy of the diagnosis of CM in this population [5]. Migraine in this population can be misdiagnosed as sinusitis, attempted school skipping, and cerebral neoplasia, which may culminate in unnecessary testing [6].
CM is a common disorder in children, and its incidence in adolescents presents a considerable increase [7]. Irrespective of age, the prevalence of chronic migraine is estimated at 1.5–2% in general population. On the other hand, its prevalence is 3% (from 3 to 7 years of age), 4–11% (from 7 to 11 years of age), and 8–23% (at 11 years of age), with a mean age of onset of 7.2 years for male and 10.9 years for female [8, 9]. Migraine is the 6th most disabling disease worldwide between the ages of 10 and 14 years and the 5th between the ages of 15 and 19 years [10]. In addition to toe the line impact inflicted by pain itself, migraine generates serious consequences in children’s and adolescent’s routine, since it is responsible for school absences, negatively affecting academic performance. It also has social impacts, since it hinders the child’s interactions with his peers, and economic, due to the costs generated by the treatment [11]. Migraine has two-fold higher prevalence in females when compared to their peer male adolescents [12, 13, 14, 15, 16, 17]. In women, the prevalence of migraine increases during adolescence, presenting a maximum prevalence at 30 years of age, decreasing sharply after menopause [12, 14, 17], since 50–60% of women report having migraine during their menstrual period [18]. In the American Migraine Prevalence and Prevention Study (AMPP), patients with CM presented with depression, anxiety, and chronic pain twice as much as patients with episodic migraine [17]. Abu-Arafeh et al., in 2010, estimated that the overall prevalence of migraine in children is 7.7% (9.7% in female and 6.0% in male), being more common in female after completing 11 years of age, in male before the age of 7, and being equal in both sexes between 7 and 11 years of age [19, 20]. In another study, WöberBingöl et al. reported general prevalence of migraine of 9.1% [21].
Among the risk factors for CM, the following are included:
gender (female, once migraine has been associated with menorrhagia, dysmenorrhoea, and endometriosis [22]);
age group;
ethnicity: more specifically, white;
genetic factors: family history of headache, mental disorders [5, 22, 23], anxiety, and depression [5, 23], as well as comorbidities, such as sleep disorders [5, 23] (sleep apnea syndrome and hypopnea, snoring, and insomnia [22]), obesity [23], epilepsy [24], hypertension, asthma, hypothyroidism, genitourinary disorders, musculoskeletal disorders, [22] and gastrointestinal disorders [22, 24];
family and environmental factors: divorce [23], socioeconomic class [5, 23], and low level of education [5]; and
other factors: pro-thrombotic factors [5] and pro-inflammatory factors [5, 23].
In addition to the factors mentioned above, others still under study may be related to the pathophysiology of CM and, therefore, represent risk factors such as traumatic brain injury, epilepsy, hemodialysis, and excessive use of symptomatic medications.
The existence of correlation between CM and traumatic brain injury was the subject of a systematic review study published by Sowell et al., in 2017, in which was sought to relate it to posttraumatic chronic headache (PTCH) in children and adolescents. In this study, it was observed that 7.6% of children with PTCH presented migraine [24], thus disclosing it to be a relatively common condition and that it should be considered.
Another factor that may be correlated with CM is epilepsy. Both migraine and epilepsy are considered neuronal hyperarousal-related diseases which can be partially prevented by antiepileptic drugs. According to the Center of Disease Control (CDC), 16.2% of adults with no history of epilepsy have severe headache or migraine, while those with active epilepsy have 35.5% of prevalence [25]. Therefore, although the correlation between epilepsy and migraine has not been completely elucidated yet, there are strong indications for such an interdependence.
Regarding hemodialysis in pediatric and adolescent patients with chronic kidney disease, Davidovits and Eidlitz Markus, in a study published in the International Headache Society, concluded a three-fold higher prevalence of headache among patients in hemodialysis compared to those with chronic kidney disease without this treatment, the most commonly described type of headache being migraine. Furthermore, other variables were associated with headaches, such as anemia, hyperparathyroidism, and low glomerular filtration [26].
Notwithstanding, excessive symptomatic medication is also described in the literature as a risk factor for CM. With this in mind, Rojo et al. made a comparison between patients with CM with and without excessive medication use (analgesics, tryptans, ergotamine, and opioids). In the study, it was observed that individuals overusing symptomatic medication had the onset of migraine at a younger age, with a longer progression time before looking for a specialist, as well as a higher percentage of preventive prior treatment (mainly antidepressants), compared to those without excessive use of medication [5].
Even though there are differences between the clinical findings of CM in the pediatric population and other age groups, due to the scarce evidence in relation to diagnostic methods aimed specifically at these patients, the International Classification of Headache Disorders, of Headache Classification Committee of the International Headache Society (IHS), 2018, is used, the same applied to the adult population [1, 5].
According to IHS, CM is characterized by occurrence of ≥8 days of migraine in a month and ≥15 headache days. Migraine attacks can be with and/or without aura [1]. In this case, migraine without aura is a headache lasting 4–72 h, which has at least two of the following characteristics: (1) unilateral location; (2) pulsatile character; (3) moderate to strong pain intensity; and (4) is exacerbated by routine physical activities and, during the headache, the patient has at least one of the following symptoms: (1) nausea and/or vomiting; (2) photophobia; and (3) phonophobia [1].
On the other hand, migraine with aura is a headache with the same characteristics mentioned above, plus one or more symptoms of fully reversible aura, and may be visual, sensory, speech and/or language, motor, brain stem, or retinal. Furthermore, crises should have at least three of the following characteristics: (1) at least one symptom of aura gradually spreads for more than 5 min; (2) two or more aura symptoms occur in succession; (3) each individual aura symptom lasts 5–60 min; (4) at least one symptom of aura is unilateral; (5) at least one symptom of aura is positive; and (6) aura is accompanied, or followed within 60 min, by headache [1].
Although the use of IHS criteria is recommended, the health professional should know the peculiarities of CM in adolescent population in order to complement the diagnosis. The characteristics of the headache tend to be more prominent in this group, since the brain is in the growth and development process. Furthermore, the duration of pain crises may be less than 1 h, contrary to the IHS criteria, which mentions a minimum duration of 2 h [1, 6, 27]. A direct relation between the patient’s age and duration of crises is observed, being younger shorter the duration of the crisis [4]. An important information is that adolescents may present nonpulsatile and bilateral pain, which may induce the misdiagnosis of tensional headache [2, 6, 27].
Approximately 10% of young people with migraine present aura, from visual, sensory, speech, or language disorders, motor, or brain stem changes, manifesting themselves as scotomas, paresthesias, dysphasias, hemiplegia, ataxia, or confusion. The suspicion of other diseases of the central nervous system should be listed through fever, nuchal stiffness, altered mental status, absence of family history of migraine, occipital or positional headaches, or headaches that constantly awaken the individual during sleep [28, 29, 30].
In adolescents, it is common for patients with migraine to have comorbidities such as epilepsy and atopy. The most common atopic disorders reported concomitantly with CM are seasonal rhinitis, conjunctivitis, and asthma, with correlation with positive family history. Regarding epilepsy, it is mainly associated with migraine with aura, which corroborates the role of depression of cortical propagation. Another hypothesis is that both, migraine and epilepsy, have the influence of canalopathies on their pathophysiology [30, 31, 32].
The mechanisms responsible for the occurrence of CM are not yet fully understood. Thus, the existing model to explain its pathophysiology still has gaps. It is accepted that migraine occurs by complex mechanisms involving activation and sensitization of trigeminal nociceptive pathways, especially its ophythalmic division, changes of the autonomic nervous system function, descending pain modulator system dysfunction, thalamic sensitization, and central sensitization due to the excessive use of medication in the acute treatment of pain crises.
It is noteworthy that the córtex of patients with migraine is hyperexcitable and abnormally sensitive to external stimuli. Due to triggering factors, the so-called cortical spreading depression (CSD) occurs, characterized by a slow propagation wave (2–6 mm/min) of sustained neuronal depolarization, which generates a transient peak of intense activity as it progresses in the tissue, followed by a long-term neural suppression. That is, there is a period of electrochemical hyperactivity followed by cortical inactivity, which results in the release of substances in the extracelular environment (ECE), such as K+ and H+ ions, nitric oxide, arachidonic acid, and prostaglandins [33, 34, 35]. Such a change in the ECE may activate or sensitize trigeminal afferences. The trigeminal ganglia, once stimulated, releases neuropeptides, causing inflammation of the dura mater. Cernuda-Morollón et al. demonstrate in their studies that interictal levels of calcitonin gene-related peptide (CGRP) and intestinal vasoactive peptide (IVP) are higher in CM [36, 37]. Thus, meningeal inflammation occurs, with vasodilation and endotelial dysfunction, resulting in plasma leakage and release of more inflammatory cytokines by mast cells. Thereby, neurogenic inflammation can lead to activation and sensitization of meningeal trigeminal afferences—a phenomenon known as peripheral sensitization [38, 39, 40].
A widely spread hypothesis is that increased peripheral nociceptive processing triggers increased activity of the descending pain modulation system, resulting in increased oxidative stress and consequent nociceptive modulation, further lowering the threshold for new pain crises. However, so far studies have not shown association between gene polymorphisms associated with oxidative stress and the occurrence of CM. On the other hand, repetitive painful stimuli on the trigeminal nerve cause activation of the pain modulating descending system in several portions, including the periaqueductal gray matter, showing that during migraine attacks, the neurons of this region show increased activity, which may lead to oxidative stress and finally dysfunction of nociceptive modulation by such system [33, 41, 42, 43].
Thalamic modulation of trigeminal afferences appears to be related to the development of cutaneous allodynia in migraine, as sensitized thalamic neurons process nociceptive information from cranial meninges, along with sensory information from the scalp, skin, face, body, and limbs. Furthermore, the use of drugs that act modulating trigeminal afferences on the thalamus is effective in the preventive treatment of migraine attacks, such as topiramate, sodium valproate, and CGR66 receptor antagonists, corroborating the role of this structure in the chronicity of migraine [44, 45, 46, 47].
The overuse of medications to relieve acute migraine may also lead to the chronicity of this condition, through the drug-mediated central sensitization mechanism, leading to increased susceptibility to cortical spreading depression. Central sensitization manifests clinically from increased pericranial sensitivity and allodynia [48, 49, 50].
Andersen et al. demonstrated in 2016 that during pain crises serum miRNA changes occur, and in patients with CM such changes persist the same in periods without pain. This implies the possibility of serum miRNA changes as a pathogenic feature of migraine. Thus, the study suggests that serum miRNA dosage is a potential biomarker of this disease [51].
According to Oakley et al., there is a possibility that obesity may be involved in the pathophysiology of migraine in the pediatric population. It is hypothesized that there is an overlap of the central and peripheral neural pathways responsible for the regulation of diet and those linked to the pathogenesis of migraine [33, 52]. Peterlin et al. demonstrated that several hypothalamic peptides, proteins, and neurotransmitters involved in the mechanisms of hunger also participate in the pathophysiology of migraine, such as serotonin, orexin, and adipokines. It is possible that the release of these substances, associated with the mechanism of diet and/or obesity states, may act as a trigger or corroborate the development of migraine. There is also the possibility that lifestyle and behavioral differences influence the relationship between migraine and obesity, such as differences in diet and physical exercise, or the lack of it [33, 53].
The treatment of chronic migraine in adolescents aims not only to reduce frequency, duration, and intensity of the headache attacks, but also to reduce the consequences of this condition on the patient’s quality of life, seeing as he or she is going through a process of growth and development. It also aims to treat comorbidities and reduce the social impact of the disease, such as school absences, school underachievement, and reduced peer interactions. Thus, the treatment should be developed from a multiprofessional perspective, with the help of pediatricians, neurologists and psychiatrists, psychologists, educators, and nutritionists, among others [54].
Firstly, family members should receive detailed information about the adolescent’s diagnosis and ensure that the condition is not secondary to malignant diseases, in order to transmit confidence to the patient and their parents, thus contributing to treatment adherence [5].
Proper living habits are of paramount importance for treatment. However, the health professional should be careful to not excessively restrict the activities of young people, as this may lead to difficulties in adherence [55].
Sleep disorders are important comorbidities of chronic migraine. Therefore, regular sleep habits should be advocated in order to promote restful and restorative sleep. For this, the teenager can use some techniques, such as scheduling a daily bedtime, avoid using electronic media when in bed, avoid eating 4 h before bedtime, and avoid daytime naps. Still, sleep deprivation can be a triggering factor for pain crises, corroborating the importance of a well-slept night [56, 57].
Regarding food, it is important to prioritize regular meals, with the consumption of healthy foods and adequate hydration. Caffeine and tobacco should be avoided. The performance of physical activities should be encouraged, as it not only reduces the occurrence of crises, but also is able to assist in the treatment of depression and anxiety comorbidities, when present [58, 59].
Gelfand et al. emphasize that the patient should be alerted about the negative effects of overuse of medications, as it is one of the factors responsible for the chronicity of migraine, from the central sensitization mechanism, as previously explained about the pathophysiology [60].
Kroon Van Diest et al. [61], based on a randomized study, demonstrated the importance of Cognitive Behavioral Therapy (CBT) for adherence to pharmacological treatment and institution of lifestyle changes [62]. CBT aims, through interventions guided by a psychologist, to promote the patient’s active learning in order to implement skills to deal with migraine and related conditions and situations to her. Thus, during the sessions, behavioral coping skills are worked out, such as problem-solving and thought restructuring, that is, the adolescent is urged to change their ideas, beliefs, and attitudes regarding his chronic condition [62]. CBT, in combination with amitriptyline, is suggested as a first-line treatment in the context of CM in adolescents [61].
Regarding acute pharmacological treatment, that is, to relieve pain crises, nonsteroidal anti-inflammatory drugs (NSAIDs) and triptans are used [28, 63, 64]. Among NSAIDs, the most used are ibuprofen and naproxen [28]. Evers et al. demonstrated that ibuprofen is better than placebo. There is no evidence regarding the efficacy of acetaminophen in adolescents [63, 65, 66].
In the adolescent population, the following triptans are indicated: sumatriptan, rizatriptan, zolmitriptan, and almotriptan. Studies indicate that such drugs are the most effective in relieving pain during acute crises in adolescents, with no statistically significant differences between them [63]. According to Derosier et al., the combination of naproxen and sumatriptan was superior to placebo when analyzing the permanence of analgesia after 2 h, with sumatriptan + naproxen sodium 10 mg + 60 mg (29%; p = 0,003), 30 mg + 180 mg (27%; p = 0.003), and 85 mg + 500 mg (24%; p = 0.003) versus placebo (10%) [67]. Among the side effects of this class, the most common are mild fatigue, paresthesia, dizziness, and taste disorders [28, 64].
In the case of long-term migraine or migratory status, that is, disabling crisis lasting more than 72 h, hospital treatment may be required for intravenous administration of prochlorperazine with ketorolac, which Brousseau showed that 57% of patients had pain reduction in 60 min [28, 68]. Dihydroergotamine (DHE) has been shown to be well tolerated and effective in acute treatment and is generally administered in hospital setting, and an association with metoclopramide or prochlorperazine is suggested, which is able to attenuate gastrointestinal side effects [28, 69]. Ayulo et al. suggested the use of intravenous lidocaine for the treatment of migratory status in adolescents, but further evidence is needed to ensure the long-term efficacy and safety of this medication [28, 70].
Prevention of chronic migraine attacks in adolescents remains limited [71, 72]. Newly developed therapies, including drugs, biologic products, and neuromodulation devices are safe and well tolerated in adults [73, 74, 75, 76, 77, 78, 79, 80]. Studies in the pediatric population are still being developed [81]. Therefore, the current nonpediatric prevention will be presented.
Epidemiological studies suggest that approximately 38% of migraine patients require preventive therapy, however, only 3–13% currently use it [12]. The prevention of CM currently presents concrete evidence for the following drugs: onabotulinumtoxina [82], topiramate [83, 84], and fremanezumab (TEV-48125) [85]. Other therapies, such as β-blockers and amitriptyline, are often used despite the lack of evidence, as they are not fully effective or poorly tolerated, which may culminate in low adherence rates [85]. However, a randomized study developed by Powers et at. demonstrated that amitriptyline, when combined with Cognitive Behavioral Therapy (CBT), reduces migraine disability and pain days by 1 month—adolescents receiving amitriptyline alone (group A) reduced the number of days with headache in 1 month of 6.8 days, while those who associated amitriptyline with CBT (group B) had a reduction of 11.5 days; headache disability as assessed by the Pediatric Migraine Disability Score (PedMIDAS) decreased by 52.7 points in group B versus 38.6 points in group A [62].
Currently, new forms of prevention have been proposed, based on the understanding of the pathophysiology of the disease. The calcitonin gene-related peptide (CGRP) has increased plasma concentration during a migraine attack [86, 87, 88]. Therefore, a human monoclonal antibody against the receptor of CGRP, named Galcanezumab, which was effective in preventing migraine when given at a dose of 150 mg twice a month, was developed in a study by Skljarevski et al. [89]. Treatment with self-administered injections of subcutaneous galcanezumab [90], subcutaneous fremanezumab [91], and enerumab [92] was associated with a reduction in the number of monthly days of migraine (5.6–6.5 days, 1.3–1.5 days, and 6.6 days, respectively).
Recent studies indicate that nonpharmacological strategies are effective in preventing CM, reducing the activation of peripheral nociceptive terminations. This can be accomplished by manipulation technique, increasing the range of motion and reducing the stiffness of the cervicothoracic spine. In the study by Gandolfi et al., patients undergoing this treatment had lower consumption of analgesics, NSAIDs, and triptans [93].
Guilbot et al. showed that
CM in adolescents is a disease of clinical and epidemiological importance, since it can affect approximately a quarter of the pediatric population with an average of 11 years of age, being considered debilitating due to psychological, social, and economic repercussions.
This disorder has intrinsic and nonmodifiable (genetic and comorbidities) risk factors, as well as modifiable risk factors, such as behavioral and socioenvironmental variables, in addition to several other elements still under study that may contribute to the onset or that are correlated.
The diagnosis of migraine is made clinically according to the ICHD-3 criteria, taking into account the particularities of the adolescent population.
Pathophysiology, as well as risk factors and prevention, are still not completely elucidated items in CM. However, it is generally agreed that migraine occurs from complex mechanisms involving activation and sensitization of trigeminal nociceptives pathways, alteration of autonomic nervous system function, pain modulating descending system dysfunction, thalamic sensitization and further central sensitization due to the overuse of medicines in the acute treatment of pain crises.
Treatment, in turn, is multiprofessional and supported by both pharmacological and nonpharmacological measures. Nonpharmacological measures include guidance to parents and family members about the chronic condition, as well as sleep hygiene and adoption of good eating habits by the patient. In the case of drug measures, NSAIDs and triptans are the first option and, in case of migraine status, prochlorperazine associated with intravenous ketorolac added to recent evidence suggesting the use of intravenous lidocaine.
Finally, studies are still needed to fill the gaps present for the complete understanding of this complex and debilitating entity that is chronic migraine. Through a better understanding of the pathophysiological mechanisms responsible for the development of CM, as well as its risk factors, it will be possible to develop more effective prevention and treatment methods in adolescents.
Supporting women in scientific research and encouraging more women to pursue careers in STEM fields has been an issue on the global agenda for many years. But there is still much to be done. And IntechOpen wants to help.
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\\n\\nWe aim to publish 100 books in our Women in Science program over the next three years. We are looking for books written, edited, or co-edited by women. Contributing chapters by men are welcome. As always, the quality of the research we publish is paramount.
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\n\nWe aim to publish 100 books in our Women in Science program over the next three years. We are looking for books written, edited, or co-edited by women. Contributing chapters by men are welcome. As always, the quality of the research we publish is paramount.
\n\nAll project proposals go through a two-stage peer review process and are selected based on the following criteria:
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\n\nInterested? If you have an idea for an edited volume or a monograph, we’d love to hear from you! Contact Ana Pantar at book.idea@intechopen.com.
\n\n“My scientific path has given me the opportunity to work with colleagues all over Europe, including Germany, France, and Norway. Editing the book Graph Theory: Advanced Algorithms and Applications with IntechOpen emphasized for me the importance of providing valuable, Open Access literature to our scientific colleagues around the world. So I am highly enthusiastic about the Women in Science book collection, which will highlight the outstanding accomplishments of women scientists and encourage others to walk the challenging path to becoming a recognized scientist." Beril Sirmacek, TU Delft, The Netherlands
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Simulation studies have been applied separately to two different control systems in order to demonstrate the feasibility, performance, and effectiveness of the proposed control methodology through the design of the sliding mode controller: firstly, the position control of an armature-controlled dc servo motor subject to a varying external disturbance, and secondly, a two-link robot manipulator that were also analyzed in terms of its robustness by adding extra mass to one of the joints to be able to maintain the trajectory in the sliding surface. Simulations show that a fast convergence rate, and therefore quick response, the ability to reject the varying external disturbances, and the robustness against the model uncertainty assumed to be unbounded and fast-varying have all achieved its purpose entirely. This study also examines the advantages of SMC and PID comparably. The results given here do not contradict the view that one can use it instead of the other without losing too much performance, and confirm the success of the presented approach.",book:{id:"9893",slug:"automation-and-control",title:"Automation and Control",fullTitle:"Automation and Control"},signatures:"İhsan Ömür Bucak",authors:[{id:"319745",title:"Associate Prof.",name:"İhsan",middleName:"Omur",surname:"Ömür Bucak",slug:"ihsan-omur-bucak",fullName:"İhsan Ömür Bucak"}]},{id:"37999",title:"Graphics Generator for Physics Research",slug:"graphics-generator-for-physics-research",totalDownloads:2081,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1904",slug:"automation",title:"Automation",fullTitle:"Automation"},signatures:"Eliza Consuela Isbăşoiu",authors:[{id:"111059",title:"Dr",name:null,middleName:null,surname:"Isbasoiu",slug:"isbasoiu",fullName:"Isbasoiu"}]},{id:"71965",title:"Polygonal Approximation of Digital Planar Curve Using Novel Significant Measure",slug:"polygonal-approximation-of-digital-planar-curve-using-novel-significant-measure",totalDownloads:603,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter presents an iterative smoothing technique for polygonal approximation of digital image boundary. 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The combined thermodynamic/heat transfer relations of the phase change materials (PCMs) in silica nanoporous materials are developed to obtain mass, thickness, and temperature excursion as functions of percentage area of PCM under given maximum energy and thermal flux. The studies show that PCMs are one of the most preferred methods to thermal control applications that can effectively delay or modify the temperature rise of the surface of the aircrafts subjected to high thermal flux. This chapter also introduces the preparations of porous ceramic matrix phase change composite, putting PCMs to use in the internal thermal control materials for the hypersonic vehicles. Porous ceramic matrix serves as the supporting material, which provides structural strength and prevents the leakage of melted PCMs, and PCMs act as thermal absorb material limiting the temperature abruptly rising of the aircrafts. 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He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). 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