Chapters authored
Potential Antioxidative Effects of Kolaviron on Reproductive Function in Streptozotocin-Induced Diabetic Wistar Rats
The present study investigated the effects of Kolaviron (KV) on the testicular and epididymal tissue antioxidant status in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ at 50 mg/kg body weight. The antioxidant status was studied by evaluating epididymal and testicular levels of malondialdehyde (MDA), a lipid peroxidation (LPO) marker, and the activities of catalase (CAT) glutathione peroxidase (GPX) and superoxide dismutase (SOD) were also assessed using biochemical techniques. Diabetes induction resulted in testicular and epididymal LPO and adversely affected the activities of antioxidant enzymes evident by a noticeable decrease in enzyme activity in both tissues. The potential antioxidative effects of KV in the testicular and epididymal tissues of STZ-induced diabetes were revealed by its ability to mitigate against LPO and increase the activity of antioxidant defense enzymes in the reproductive tissues studied. KV might potentially be used as an antioxidant as well as antidiabetic treatment; however, further studies are needed.
Part of the book: Antioxidants
Role of Red Palm Oil in Male Obesity and Infertility Prevention
The African continent has wide, varied, and rich plant diversity due to its climate. Some of these plants and their products have received tremendous attention due to their benefits in treating and managing ailments that plagues humanity. Red palm oil (RPO) is one of such natural products that have immense nutritional value with ability to ameliorate cardiac- and reproductive-related disorders. In this review article, the current knowledge on the potential of RPO as a phytomedicine to lessen or even prevent the negative impact of obesity on general health status and male fertility was evaluated. This study was done using electronic databases such as PubMed, Scopus, Science Direct, Google Scholar and Web of Science. The study revealed some controversies and inconsistent reports on the effect of RPO on obesity and male fertility which needs further research using appropriate experimental models of obesity. Obesity is known to disrupt male fertility by causing changes to the hypothalamic- pituitary-gonadal axis, thus impairing steroidogenesis and spermatogenesis. As spermatozoa are extremely sensitive towards oxidative stress, a carefully balanced daily supplementation of normal diet with antioxidant-rich RPO might be useful to protect spermatozoa and preserving male fertility. RPO was shown to be useful to protect against or ameliorate toxin- or medical condition-induced male infertility. Also, RPO is packed with powerful antioxidants like carotenoids and vitamin E which helps to prevent cell damage. However, its role in obesity prevention remains a debate.
Part of the book: Elaeis guineensis