Pradeep Chatterjee

North Carolina Central UniversityUnited States of America

Dr. Pradeep Chatterjee completed his undergraduate studies in Chemistry from the Indian Institute of Technology, Kharagpur and Indian Institute of Technology, Kanpur, India. He received his Ph.D. in Chemistry from Columbia University, New York, developing novel technology to generate psoralen-DNA monoadducts photochemically. His postdoctoral training at MIT, Cambridge, Massachusetts, elucidated the role of the cytoskeleton to assemble the nucleocapsid proteins of Vescicular Stomatis Virus. His studies continued at Princeton University, Princeton, with adenovirus nucleoprotein assembly and eukaryotic gene transcription. Dr. Chatterjee then joined DuPont-Merck to study mechanisms of cell killing by antitumor drugs using both biochemical and genetic approaches. He joined BBRI-NCCU in 1999 to start a research program in genomics. His research interests include application of genomic and molecular genetic technologies to understand eukaryotic gene regulation using the zebrafish model system, and developing new technology to map genetic markers and cis-acting gene-regulatory elements that influence expression from large distances along the DNA.

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Latest work with IntechOpen by Pradeep Chatterjee

This book focuses on the numerous applications of Bacterial Artificial Chromosomes (BACs) in a variety of studies. The topics reviewed range from using BAC libraries as resources for marsupial and monotreme gene mapping and comparative genomic studies, to using BACs as vehicles for maintaining the large infectious DNA genomes of viruses. The large size of the insert DNA in BACs and the ease of engineering mutations in that DNA within the bacterial host, allowed manipulating the BAC-viral DNA of Varicella-Zoster Virus. Other reviews include the maintenance and suitable expression of foreign genes from a Baculovirus genome, including protein complexes, from the BAC-viral DNA and generating vaccines from BAC-viral DNA genomes of Marek's disease virus. Production of multi-purpose BAC clones in the novel Bacillus subtilis host is described, along with chapters that illustrate the use of BAC transgenic animals to address important issues of gene regulation in vertebrates, such as functionally identifying novel cis-acting distal gene regulatory sequences.

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