Main psychometric properties of ankle-related self-report measures.
\r\n\tSome of them are potential hazards caused by novel (bio)technologies, such as nanoparticles or process-related toxicants. Others are well-known hazards that climate change and new trends in food consumption have now moved under the spotlight. Some are due to the deliberate adulteration of food for economic reasons, that is strongly affecting the global market.
\r\n\tFood scientists are strongly involved in tackling this global challenge, supported by novel technologies and ICT-based tools. On one hand, innovative analytical approaches, mainly based on omics science and big data, may offer a great support for hazard characterization and risk assessment. On the other hand, early warning tools are strongly needed to efficiently support risk management and avoid food losses.
\r\n\tAlthough many contaminants are regulated worldwide and routine control plans ensure the compliance of food before entering our plate, scientists are now focusing their research not only on single compounds, but mainly on a cocktail of toxicants thanks to biomonitoring and imaging techniques. This change in the approach will lead to a new design of risk assessment within few years.
\r\n\tBesides traditional players, like scientists and policy-makers, also agro-food companies are investing efforts and resources in the identification and assessment of emerging risks, to meet consumer’s demand of safer food and prevent misleading communication.
\r\n\tIt is clear that the food safety scenario is rapidly changing, driven by innovation and big data. This book intends to provide the reader with a comprehensive overview on the methodological advances the scientific community has brought about to face emerging risks and new trends.The main emerging risks will be covered, and methodological improvements will be outlined. Strategies in management and communication will be described. New market trends and consumers’ behavior leading to a change in the future scenario, will be discussed.
The main purpose of this chapter is to present a clinical and scientific perspective of the applicability of self-report outcome measures on the assessment of rehabilitation intervention designed to treat ankle/foot disorders. Some aspects about the development of these clinical tools will be briefly discussed in order to offer clinicians and scientists some criteria to better select an appropriate measure for a given clinical goal. In addition, a presentation is given of how the item response theory (IRT), by using Rasch analysis, can be used to assess such clinical measurement tools and to enrich rehabilitation data concerning clinical intervention effectiveness.
\nThroughout the history of orthopedic field, the main focus of clinical relevant outcome measures used to be those related to body structure and function, quantifying movement restrictions, such as range of motion or functional impairments like muscle strength. By this point of view, treatment goals and definitions of successful interventions captured mainly what is direct important for the healthcare professional rather than for the patient. However, what is crucial and naturally understandable for patients is functionality and disability, which brings a clear necessity to measure dysfunction at this level. Furthermore, the International Classification of Functionality (ICF) proposed by the World Health Organization (WHO) suggests that health issues should be considered by taking into account individual function, activity, and social participation. The impact that injuries, illnesses, and any other harm might have upon health, especially over functionality and quality of life, must be considered in a context of clinical evaluation in the health area.
\nUsually, ankle dysfunctions require the involvement of a wide variety of healthcare professionals in order to achieve excellence in recovery and functionality. This is particularly true when the treatment plan includes surgery, medications, rehabilitation program, and many other interventions carried out by different professionals. Multidisciplinary healthcare thus requires instruments that work across distinct disciplines in a sense of combining them and unifying perspectives.
\nThe health team may have priorities that can diverge from patient-specific needs or beliefs. This may happen often because both look for a health condition from different backgrounds and starting points and this communication noise may lead to inappropriate treatment plan and can decrease patient’s compliance.
\nFocusing on the patient, who is most interested in full recovering of his/her health, quantifying subjective perception of functional status as well as health-related quality of life represents a challenge both for clinicians and researches, particularly in the field of rehabilitation. A patient-centered or also called client-based assessment tool is needed and should meet the clinical needs of both the patient and the healthcare team, in such a way that it must be practical and accepted by everyone involved in a treatment context [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17].
\nClient-based assessment instruments, like questionnaires, are tools suitable to comprise the domains of activity and social participation being commonly the selected instrument for the assessment of health-related quality of life. They have the ultimate goal of transforming subjective measures into objective data that can be quantified and analyzed. Self-report questionnaires are useful both for clinical and scientific research purposes once they combine efficiency, reliability, and low cost and, at the same time, meeting the necessity to quantify patient-centered clinical outcome measures.
\nEvery clinical outcome measure may have five goals in order to be useful in a clinical-based scenario. The acronym that exemplifies this feature is known as SMART goals and can be visualized in \nFigure 1\n.
\nSMART goals for a clinical assessment tool.
One way to classify questionnaires and functional scales is by their assessment application (see \nFigure 2\n). In this case, they can be categorized as being generic or specific. Generic questionnaires measure overall health, within biopsychosocial approach, and are intended to be applicable across a wide spectrum of diseases, interventions, demographic, and cultural subgroups. The most famous and used instrument that encompasses this properties is the 36-item short-form health survey (SF-36), which measure health-related quality of life in two main domains of mental and physical health. On the other hand, disease-specific measures aim to assess the most important traits usually affected by a condition of interest and that can be used to determine clinical improvement or deterioration. The foot and ankle outcome score (FAOS) and the American Orthopedic Foot and Ankle Society ankle-hindfoot scale (AOFAS) are both examples of condition-specific measures.
\nQuestionnaires and functional scale classification schema.
Another form in which self-report tools can be organized is in relation to the clinical function (see \nFigure 2\n). Within this context, they can be discriminative or evaluative instruments. The selection of one type over the other depends on the desired use of the instrument. Discriminative instruments, such as the Cumberland ankle instability tool (CAIT), can be used to identify individuals with a particular disorder, in this case, chronic ankle instability. Evaluative instruments are developed to follow up and measure an individual’s change, thus assessing the effectiveness and outcome of treatment. The foot and ankle ability measure (FAAM) and lower extremity functional scale (LEFS) are examples of evaluative instruments. Information acquired from an evaluative instrument is useful only if evidence is available to support the interpretation of scores obtained in the specific population in which the instrument is intended to be used.
\nThe main factors when considering practicality are the following:
The time expended to self-answer or to administer the questionnaire
The necessity of formal training or prior experience
Special or specific set up
Scoring method and use of electronic devices or software
Although patients may appear to have time to complete self-report measures in the waiting room before being seen for therapy, lengthy or numerous self-report forms may interfere with patient care. Some people may fatigue while completing self-report forms, and this fatigue could influence their responses. When selecting a self-report instrument, clinicians should pay attention on the time needed to fulfill the questionnaire. Usually, the authors report this time in scientific publications or in user’s manual, when applicable. For a self-administered questionnaire, ideally no more than 10 min should be needed to answer all items.
\nAnother important point to consider is the form of test administration. Some self-report questionnaires, especially translated versions, may require a structured interview for a proper measurement reliability. Although this procedure is likely to increase the time needed to fill in the questionnaire, it is essential to achieve an acceptable level of accuracy in measurement. Instructions for taking a test are sometimes not sufficient, and special training and experience may be necessary. Usually, there is no need for special training, but test familiarization and reading the user’s guide, when applicable and suggested by the test developers, may be helpful. A great advantage of self-report measures is that no equipment or specific setups, and no professional or support staff are needed to help with the tests.
\nA strong point for a clinician is the importance of immediate feedback and interpretation of test result. Consequently, a scoring method that can be done manually without any software or computer assistance is desirable. It is common practice for a test’s score to be attained by just summing up the individual items score and then transforming this result into a percentage. It is important to know the correct interpretation of this value, whether 100% means full function or the worst score for functionality.
\nSome instruments result in a single composite score or in a composite score and subscale scores for components of the item being measured. A single composite score can be desirable for communicating findings to others and for identifying people who are at risk for chronic ankle instability, for example. A composite score can be useful for discriminative instruments once a single cutoff score is an important clinical information for a diagnosis process. However, a single composite score may not represent a comprehensive analysis about physical function or ankle-related functionality for a specific task or domain. Subscale scores for components of physical function, like activities of daily living or sport related tasks, may be more useful for planning intervention and monitoring outcomes.
\nIn order to ascertain that a questionnaire has proper methodological quality, information about its psychometric properties must be available. Ideally, although potentially time-consuming, information about the development of the questionnaire can sometimes be useful for a better comprehension about target population and/or medical conditions. Some author’s suggest eight criteria that should be taken into account when assessing the quality of such outcome measures. These include (1) conceptual and measurement model; (2) content and construct validity; (3) reliability; (4) responsiveness; (5) floor and ceiling effects; (6) internal consistency; (7) feasibility to answer, administer, and interpret; and (8) cultural and language adaptations (translations). Reference values for each of these variables have also been suggested aiming to help clinicians and researchers in the selection and use of the clinical assessment tool that bests suits their necessity.
\nFor the purposes of this chapter, four basic variables will be addressed in detail. They contain the minimum information needed to select and use a self-report questionnaire. They are validity, reliability, internal consistency, and responsiveness.
\nContent validity examines the extent to which the concepts of interest are comprehensively represented by the items in the questionnaire. It is very important to know about the following aspects regarding the development of a questionnaire for an appropriate judgment of content validity:
\n
\n
\n
\n
\n
Evidence for construct validity includes how the scores on the instrument relate to other measures of the construct, in a manner that is consistent with theoretically derived hypotheses concerning the concepts that are being measured. Construct validity should be assessed by testing predefined hypotheses. When testing expected correlations between measures, this can be called convergent validity or divergent validity when dealing with expected differences in scores between “known” groups.
\nSimilar to construct validity is the criterion validity, which refers to the extent to which scores on a particular instrument relate to a gold standard. In a situation where there is no gold standard test or, at least, a well-established measurement tool for a given clinical condition, the analysis of criterion validity can become quite challenging. In these cases, face validity can be achieved by the process of item selection and item reduction. This indicates whether a measure appears to have been designed to measure what it is supposed to measure, in case, ankle-related functionality. Face validity, while contributing to the validity of the data obtained with a measure, is not represented by the outcome of a statistical test but by the judgment of the tester to make sure the measure has been used under similar conditions of measurement.
\nEvidence of validity is the first step when choosing an instrument to assess and interpret the effect of pathology and subsequent impairment on physical function, as well as to compare clinical intervention effectiveness.
\nReliability relates to score stability, and it concerns the degree to which patients can be distinguished from each other, despite measurement error. Reliability coefficients such intra-class correlation coefficient (ICC) take into account three sources of variation, that is:
The variation among individuals, also known as interindividual variation
The personal variation, which is the same as intraindividual variation
At last, a variation that combines those previous mentioned, which is the error attributed to the measurement itself (measurement error)
Index like ICC is used for continuous measures and is expressed as a ration between 0 (low reliability) and 1 (high reliability). High reliability is particularly important for discriminative purposes because the difference observed in a measure should be a perfect reflection of a real change and not overlapped or shadowed by any sources of error.
\nAuthors and test developers should provide clear information about which reliability measure they have used; if ICC is the case, the two-way random effect model is the best option for the far majority of cases. Pearson correlation coefficient is inadequate, because systematic differences are not considered. The correspondent of ICC for ordinal measures is the weighted Cohen’s kappa coefficient, which is so the preferred option for such variables. In groups or samples with 50 subjects or above, the value of 0.70 is the minimum recommendation for both indexes.
\nWhen adding up items with the purpose to measure, a construct is very important to know if those items are well correlated with each other and with the total score generated by them. In other words, it is highly desirable to know if the instrument is homogenous or unidimensional and so if the questionnaire as a whole measure the same concept or construct. This measure of unidimensionality is the internal consistency and is quite presumable that it should be as high or as good as possible.
\nThere are many ways to measure internal consistency. Usually they complement each other in the process of measuring unidimensionality. The principal component analysis or the factor analysis is both very good ways to determine whether the items form only one overall dimension or not. Also confirmatory or exploratory analysis, when applicable, is useful to determine if a given group of items measure one same construct, and therefore are grouped in one scale, or if it would be better to join the items in two or more subscales. The Rasch model is also a way to measure internal consistency by using the fit statistics, which is used to assess unidimensionality, and can be simply explained as a ratio between the observed response and the response predicted by the model. This analysis is also important for evidence of construct validity, which will be better explained in the proper section ahead in this chapter.
\nOnce the scale(s) is(are) defined, then the Cronbach’s alpha is the appropriate measure of choice. Here we have two possible situations:
A very low Cronbach’s alpha indicates that there is no reason to group the items together in a same scale or questionnaire, because there are not well correlated with each other
On the other hand, a very high Cronbach’s alpha suggests that maybe there are redundant items, which means that they measure almost the same attribute of functionality. When this happens it is valuable to judge if one or more items could be removed from the questionnaire.
Cronbach’s alpha should be interpreted with caution when applied to questionnaires with too many items, approximately more than 20 items. In these cases, the index is usually very high, because Cronbach’s alpha is dependent upon the number of items in a scale. The reference value for adequate internal consistency when using the Cronbach’s alpha range between 0.70 and 0.95.
\nA large number of definitions and methods have been proposed for assessing responsiveness. A very good comprehensive definition for responsiveness is the ability of the instrument to detect clinically important changes in an individual’s status over time even when these changes are small. This ability is the accuracy of the instrument that must be able to differentiate clinical observed changes from measurement error. Even though an instrument can capture very small changes, what really matters is to know if a change is clinically relevant. The Guyatt’s responsiveness ratio (RR) does precisely this comparison by relating the variability found within the subject with between the subjects. The reference value for RR is 1.96 because this happens when the minimal important change equals the smallest detectable change.
\nAnother adequate and common measure of responsiveness is the area under the receiver-operating characteristics (ROC) curve. It is very useful to define cutoff scores for discriminative purposes and to define injury severity. The reference value for the area under the curve is at least 0.70.
\nOne point that impact negatively on responsiveness is the presence of floor or ceiling effects. They are considered to be present when more than 15% of respondents achieved the lowest or highest possible score. Thus, the responsiveness is limited because changes cannot be measured in these patients nor is it possible to distinguish one from another, which compromises reliability.
\nLimitations in measurements, such as ceiling or floor effects, can usually be avoided by selecting measures that have been demonstrated to provide meaningful information about people who are similar to those being measured. In other words, the target population of each measurement tool must be considered by matching the sample, e.g., patients with the appropriate questionnaire or functional scale.
\nThe Rasch model and the factor analysis constitute two ways of assessing psychometric properties of an instrument and can be, and frequently are, used in functional scales development. These two statistical procedures have the same theoretical model, which is the item response theory. The basic concept behind IRT is that the probability of choosing a response for each item is a function of both the subject’s or patient’s ability and the difficulty level of each item.
\nWhen applying the concepts of IRT to psychometric properties analysis, it is possible to obtain more detailed information about validity, accuracy, and targeting that helps understanding the clinical meaning of a self-report instrument. It goes beyond just looking at the final score of a questionnaire or at cutoff scores. This closer look at outcome measures like functional scales adds information to those obtained by traditional statistical tests, e.g., Cronbach alpha or ICC. IRT not only improves the methodological quality when elaborating new instruments but gives clearly insights into effects of intervention as well, whether comparing groups or the subject longitudinally.
\nRasch analysis can be applied to examine instruments or assessment scales applicable in wide spectrum of disciplines, including studies in health area, education, marketing, economy, and social sciences. In the majority of evaluations, a well-defined group is selected to answer a series of predefined items. The Rasch model offers a mathematical theoretical reference by which researches that elaborate instruments are able to create comparable measures. The main point behind this model is the concept of unidimensionality, which can be summarized by the idea that useful clinical measures involve the analysis of only one human attribute at the time. In other words, it implies that the instrument measures a single latent ability. Taking a self-report questionnaire as an example, this would mean the items are organized according to their difficulty level and are placed in a single linear hierarchic scale.
\nThe Rasch model transforms ordinal scales into interval measures. This process allows us to calibrate item difficulty and subject’s ability in a same linear
where
If all items meet this probabilistic expectation, it is possible to state that the questionnaire, as a whole, assesses an unidimensional construct. This probabilistic framework constitutes the basis of Rasch model and thereby makes it possible to organize items by their difficulty level as well as by the patients’ ability level, both based on the observed answering pattern.
\nQuestionnaires should be responsive to changes in the status of the patient across the spectrum of ability. Another benefit of IRT is that it provides the amount of information that each item contributes at varying levels of ability. Easy items should provide information among low-ability levels examinees, and conversely, hard items that describe difficult tasks give information among high-ability examinees. The questionnaire final score is, therefore, the sum of all these information collected by each item, and the accuracy of it is directly proportional to the amount of information provided. The target of an evaluative instrument is to provide information across all ability ranges. Therefore, such an appropriate evaluative questionnaire should contain items that assess an individual’s ability to perform activities that span from easy to more challenging ones.
\nThe results of an item characteristic curve are valuable only when the following requirements are met:
Unidimensionality
The questionnaire measures a single latent trait.
Local independence
The answer for each item is independent from another item.
No time constraints
Should be no time limit or restriction when answering the test.
No guessing as an answer
A correct answer may not due to guessing but reflect the person’s ability.
This implies that only one latent ability accounts for the individual’s response for each of the items contained on the instrument, which is exactly the unidimensionality mentioned throughout this section. Both factor analysis and the Rasch model can ascertain this aspect of construct validity. Those items that did not fit to the model should be revised or eliminated accordingly with scale’s goals.
\nMeasures should be chosen based on whether they have been designed for and have been used with people similar to the people to be measured. For example, to assess an elite athlete’s functionality after an ankle sprain, sport subscale of the foot and ankle ability measure questionnaire should provide more clinical useful information than the whole lower extremity functional scale (LEFS). This is not because one instrument is better than the other is, but because it is a better instrument selection to the target population or the right patient.
\nThe next section shows four self-report questionnaires that are currently available for measuring ankle-related functionality. Some systematic reviews report that these instruments have very good psychometric properties and are quite useful for clinical scenarios as well as for research contexts. A brief overview for each of them is provided. For full information, we suggest to read the original studies about their development.
\nThe LEFS is a measure of activity limitation developed for musculoskeletal conditions of the lower extremity. On this scale, participants rate the difficulty in performing 20 activities of the lower extremity on a 5-point Likert scale, rating grade 0, meaning “extreme difficulty or unable to perform activity,” to grade 4, meaning “no difficulty”. The responses are summed to give a score ranging from 0 to 80, with 0 indicating high functional limitation and 80 indicating low functional restriction. LEFS was tested in a heterogeneous population with different lower limb conditions and was found to have high internal consistency (.96) and high test-retest reliability (
The FAAM is composed of two subscales named activities of daily living (ADL) and sports subscale, respectively. ADL subscale has 21 items and the sports subscale 8 items. Each item is scored on a 5-point Likert scale anchored by 4 (no difficulty at all) and 0 (unable to do). Item score totals, which range from 0 to 84 for the ADL subscale and from 0 to 32 for the sports subscale, are transformed to percentage scores. A higher score represents a higher level of function for each subscale.
\nThe FAOS is a 42-item questionnaire divided into 5 subscales: “pain” (9 items), “other symptoms” (7 items), “activities of daily living” (17 items), “sport and recreation function” (5 items), and “foot- and ankle-related quality of life” (4 items). Each question can be scored on a 5-point Likert scale (from zero to four) and each of the five subscale scores is calculated as the sum of the items included. Raw scores are then transformed to a 0 to 100, worst to best score.
\nThe CAIT is a nine-item questionnaire designed to be a discriminative instrument of chronic ankle instability. The questionnaire is structured so that the feeling of instability is reported for different types of activities such as running, walking, hopping, and descending stairs. The nine items generate a total score from 0 to 30 for each foot, in which 0 is the worst possible score, meaning severe instability, and 30 is the best possible score, meaning normal stability. The CAIT is a reliable (ICC 0.96) instrument that can discriminate stable from unstable ankles and measure the severity of functional ankle instability.
\nTable 1 summarizes the main psychometric properties of each instruments reported above.
\n\n\n | \n | \n\n | \n\n | \n\n | \n
---|---|---|---|---|
\n | \n92% of variance explained at baseline Concurrent validity r = .80 and .87, at short and medium term follow up, respectively (correlation with Olerud-Molander ankle score) | \nExperts and patients were involved in item generation and reduction | \nItem selection and reduction by patients (n = 213) Experts: not involved | \nCAIT and LEFS (α = .50, P < .01) and VAS (α.76, P < .01) Construct validity and internal reliability were acceptable (α = .83; point measure correlation for all items, >0.5; item reliability index, .99) | \n
\n | \nNo information | \nADL subscale: ICC = .89; SEM = 2,1 points Sport subscale: ICC = .87; SEM = 4,5 points | \nSubscale pain, rs = .96; subscale symptoms, rs = .89; subscale ADL, rs = .85; subscale sports, rs = .92; subscale quality of life, rs = .92 | \nICC, 0,96 | \n
\n | \nα = .92 at base line; .94 short term; .90 long term. | \nCronbach alpha for ADL subscale, α = .96 in stable group (n = 79); in changed group, α = .98 (n = 164) Cronbach alpha for sport subscale from a combined sample, α = .98 | \nSubscale pain, α = .94; subscale symptoms, α = .88; subscale ADL, α = .97; subscale sports, α = .94; subscale “quality of life,” α = .92 | \nThe threshold CAIT score was 27.5 (Youden index, 68.1); sensitivity was 82.9% and specificity was 74.7%. | \n
\n | \nGuyatt = 1.99 AUC ROC = 0.79 (95% CI = 0.70-0.88) | \nMDC ADL subscale, 5.7 MDC Sport subscale, 12.3 | \nNo information | \nNo information | \n
Main psychometric properties of ankle-related self-report measures.
\n
The main purpose of this chapter is to present a clinical and scientific perspective of the applicability of self-report outcome measures on the assessment of rehabilitation intervention designed to treat ankle/foot disorders. Some aspects about the development of these clinical tools will be briefly discussed in order to offer clinicians and scientists some criteria to better select an appropriate measure for a given clinical goal. In addition, a presentation is given of how the item response theory (IRT), by using Rasch analysis, can be used to assess such clinical measurement tools and to enrich rehabilitation data concerning clinical intervention effectiveness.
\nThroughout the history of orthopedic field, the main focus of clinical relevant outcome measures used to be those related to body structure and function, quantifying movement restrictions, such as range of motion or functional impairments like muscle strength. By this point of view, treatment goals and definitions of successful interventions captured mainly what is direct important for the healthcare professional rather than for the patient. However, what is crucial and naturally understandable for patients is functionality and disability, which brings a clear necessity to measure dysfunction at this level. Furthermore, the International Classification of Functionality (ICF) proposed by the World Health Organization (WHO) suggests that health issues should be considered by taking into account individual function, activity, and social participation. The impact that injuries, illnesses, and any other harm might have upon health, especially over functionality and quality of life, must be considered in a context of clinical evaluation in the health area.
\nUsually, ankle dysfunctions require the involvement of a wide variety of healthcare professionals in order to achieve excellence in recovery and functionality. This is particularly true when the treatment plan includes surgery, medications, rehabilitation program, and many other interventions carried out by different professionals. Multidisciplinary healthcare thus requires instruments that work across distinct disciplines in a sense of combining them and unifying perspectives.
\nThe health team may have priorities that can diverge from patient-specific needs or beliefs. This may happen often because both look for a health condition from different backgrounds and starting points and this communication noise may lead to inappropriate treatment plan and can decrease patient’s compliance.
\nFocusing on the patient, who is most interested in full recovering of his/her health, quantifying subjective perception of functional status as well as health-related quality of life represents a challenge both for clinicians and researches, particularly in the field of rehabilitation. A patient-centered or also called client-based assessment tool is needed and should meet the clinical needs of both the patient and the healthcare team, in such a way that it must be practical and accepted by everyone involved in a treatment context [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17].
\nClient-based assessment instruments, like questionnaires, are tools suitable to comprise the domains of activity and social participation being commonly the selected instrument for the assessment of health-related quality of life. They have the ultimate goal of transforming subjective measures into objective data that can be quantified and analyzed. Self-report questionnaires are useful both for clinical and scientific research purposes once they combine efficiency, reliability, and low cost and, at the same time, meeting the necessity to quantify patient-centered clinical outcome measures.
\nEvery clinical outcome measure may have five goals in order to be useful in a clinical-based scenario. The acronym that exemplifies this feature is known as SMART goals and can be visualized in \nFigure 1\n.
\nSMART goals for a clinical assessment tool.
One way to classify questionnaires and functional scales is by their assessment application (see \nFigure 2\n). In this case, they can be categorized as being generic or specific. Generic questionnaires measure overall health, within biopsychosocial approach, and are intended to be applicable across a wide spectrum of diseases, interventions, demographic, and cultural subgroups. The most famous and used instrument that encompasses this properties is the 36-item short-form health survey (SF-36), which measure health-related quality of life in two main domains of mental and physical health. On the other hand, disease-specific measures aim to assess the most important traits usually affected by a condition of interest and that can be used to determine clinical improvement or deterioration. The foot and ankle outcome score (FAOS) and the American Orthopedic Foot and Ankle Society ankle-hindfoot scale (AOFAS) are both examples of condition-specific measures.
\nQuestionnaires and functional scale classification schema.
Another form in which self-report tools can be organized is in relation to the clinical function (see \nFigure 2\n). Within this context, they can be discriminative or evaluative instruments. The selection of one type over the other depends on the desired use of the instrument. Discriminative instruments, such as the Cumberland ankle instability tool (CAIT), can be used to identify individuals with a particular disorder, in this case, chronic ankle instability. Evaluative instruments are developed to follow up and measure an individual’s change, thus assessing the effectiveness and outcome of treatment. The foot and ankle ability measure (FAAM) and lower extremity functional scale (LEFS) are examples of evaluative instruments. Information acquired from an evaluative instrument is useful only if evidence is available to support the interpretation of scores obtained in the specific population in which the instrument is intended to be used.
\nThe main factors when considering practicality are the following:
The time expended to self-answer or to administer the questionnaire
The necessity of formal training or prior experience
Special or specific set up
Scoring method and use of electronic devices or software
Although patients may appear to have time to complete self-report measures in the waiting room before being seen for therapy, lengthy or numerous self-report forms may interfere with patient care. Some people may fatigue while completing self-report forms, and this fatigue could influence their responses. When selecting a self-report instrument, clinicians should pay attention on the time needed to fulfill the questionnaire. Usually, the authors report this time in scientific publications or in user’s manual, when applicable. For a self-administered questionnaire, ideally no more than 10 min should be needed to answer all items.
\nAnother important point to consider is the form of test administration. Some self-report questionnaires, especially translated versions, may require a structured interview for a proper measurement reliability. Although this procedure is likely to increase the time needed to fill in the questionnaire, it is essential to achieve an acceptable level of accuracy in measurement. Instructions for taking a test are sometimes not sufficient, and special training and experience may be necessary. Usually, there is no need for special training, but test familiarization and reading the user’s guide, when applicable and suggested by the test developers, may be helpful. A great advantage of self-report measures is that no equipment or specific setups, and no professional or support staff are needed to help with the tests.
\nA strong point for a clinician is the importance of immediate feedback and interpretation of test result. Consequently, a scoring method that can be done manually without any software or computer assistance is desirable. It is common practice for a test’s score to be attained by just summing up the individual items score and then transforming this result into a percentage. It is important to know the correct interpretation of this value, whether 100% means full function or the worst score for functionality.
\nSome instruments result in a single composite score or in a composite score and subscale scores for components of the item being measured. A single composite score can be desirable for communicating findings to others and for identifying people who are at risk for chronic ankle instability, for example. A composite score can be useful for discriminative instruments once a single cutoff score is an important clinical information for a diagnosis process. However, a single composite score may not represent a comprehensive analysis about physical function or ankle-related functionality for a specific task or domain. Subscale scores for components of physical function, like activities of daily living or sport related tasks, may be more useful for planning intervention and monitoring outcomes.
\nIn order to ascertain that a questionnaire has proper methodological quality, information about its psychometric properties must be available. Ideally, although potentially time-consuming, information about the development of the questionnaire can sometimes be useful for a better comprehension about target population and/or medical conditions. Some author’s suggest eight criteria that should be taken into account when assessing the quality of such outcome measures. These include (1) conceptual and measurement model; (2) content and construct validity; (3) reliability; (4) responsiveness; (5) floor and ceiling effects; (6) internal consistency; (7) feasibility to answer, administer, and interpret; and (8) cultural and language adaptations (translations). Reference values for each of these variables have also been suggested aiming to help clinicians and researchers in the selection and use of the clinical assessment tool that bests suits their necessity.
\nFor the purposes of this chapter, four basic variables will be addressed in detail. They contain the minimum information needed to select and use a self-report questionnaire. They are validity, reliability, internal consistency, and responsiveness.
\nContent validity examines the extent to which the concepts of interest are comprehensively represented by the items in the questionnaire. It is very important to know about the following aspects regarding the development of a questionnaire for an appropriate judgment of content validity:
\n
\n
\n
\n
\n
Evidence for construct validity includes how the scores on the instrument relate to other measures of the construct, in a manner that is consistent with theoretically derived hypotheses concerning the concepts that are being measured. Construct validity should be assessed by testing predefined hypotheses. When testing expected correlations between measures, this can be called convergent validity or divergent validity when dealing with expected differences in scores between “known” groups.
\nSimilar to construct validity is the criterion validity, which refers to the extent to which scores on a particular instrument relate to a gold standard. In a situation where there is no gold standard test or, at least, a well-established measurement tool for a given clinical condition, the analysis of criterion validity can become quite challenging. In these cases, face validity can be achieved by the process of item selection and item reduction. This indicates whether a measure appears to have been designed to measure what it is supposed to measure, in case, ankle-related functionality. Face validity, while contributing to the validity of the data obtained with a measure, is not represented by the outcome of a statistical test but by the judgment of the tester to make sure the measure has been used under similar conditions of measurement.
\nEvidence of validity is the first step when choosing an instrument to assess and interpret the effect of pathology and subsequent impairment on physical function, as well as to compare clinical intervention effectiveness.
\nReliability relates to score stability, and it concerns the degree to which patients can be distinguished from each other, despite measurement error. Reliability coefficients such intra-class correlation coefficient (ICC) take into account three sources of variation, that is:
The variation among individuals, also known as interindividual variation
The personal variation, which is the same as intraindividual variation
At last, a variation that combines those previous mentioned, which is the error attributed to the measurement itself (measurement error)
Index like ICC is used for continuous measures and is expressed as a ration between 0 (low reliability) and 1 (high reliability). High reliability is particularly important for discriminative purposes because the difference observed in a measure should be a perfect reflection of a real change and not overlapped or shadowed by any sources of error.
\nAuthors and test developers should provide clear information about which reliability measure they have used; if ICC is the case, the two-way random effect model is the best option for the far majority of cases. Pearson correlation coefficient is inadequate, because systematic differences are not considered. The correspondent of ICC for ordinal measures is the weighted Cohen’s kappa coefficient, which is so the preferred option for such variables. In groups or samples with 50 subjects or above, the value of 0.70 is the minimum recommendation for both indexes.
\nWhen adding up items with the purpose to measure, a construct is very important to know if those items are well correlated with each other and with the total score generated by them. In other words, it is highly desirable to know if the instrument is homogenous or unidimensional and so if the questionnaire as a whole measure the same concept or construct. This measure of unidimensionality is the internal consistency and is quite presumable that it should be as high or as good as possible.
\nThere are many ways to measure internal consistency. Usually they complement each other in the process of measuring unidimensionality. The principal component analysis or the factor analysis is both very good ways to determine whether the items form only one overall dimension or not. Also confirmatory or exploratory analysis, when applicable, is useful to determine if a given group of items measure one same construct, and therefore are grouped in one scale, or if it would be better to join the items in two or more subscales. The Rasch model is also a way to measure internal consistency by using the fit statistics, which is used to assess unidimensionality, and can be simply explained as a ratio between the observed response and the response predicted by the model. This analysis is also important for evidence of construct validity, which will be better explained in the proper section ahead in this chapter.
\nOnce the scale(s) is(are) defined, then the Cronbach’s alpha is the appropriate measure of choice. Here we have two possible situations:
A very low Cronbach’s alpha indicates that there is no reason to group the items together in a same scale or questionnaire, because there are not well correlated with each other
On the other hand, a very high Cronbach’s alpha suggests that maybe there are redundant items, which means that they measure almost the same attribute of functionality. When this happens it is valuable to judge if one or more items could be removed from the questionnaire.
Cronbach’s alpha should be interpreted with caution when applied to questionnaires with too many items, approximately more than 20 items. In these cases, the index is usually very high, because Cronbach’s alpha is dependent upon the number of items in a scale. The reference value for adequate internal consistency when using the Cronbach’s alpha range between 0.70 and 0.95.
\nA large number of definitions and methods have been proposed for assessing responsiveness. A very good comprehensive definition for responsiveness is the ability of the instrument to detect clinically important changes in an individual’s status over time even when these changes are small. This ability is the accuracy of the instrument that must be able to differentiate clinical observed changes from measurement error. Even though an instrument can capture very small changes, what really matters is to know if a change is clinically relevant. The Guyatt’s responsiveness ratio (RR) does precisely this comparison by relating the variability found within the subject with between the subjects. The reference value for RR is 1.96 because this happens when the minimal important change equals the smallest detectable change.
\nAnother adequate and common measure of responsiveness is the area under the receiver-operating characteristics (ROC) curve. It is very useful to define cutoff scores for discriminative purposes and to define injury severity. The reference value for the area under the curve is at least 0.70.
\nOne point that impact negatively on responsiveness is the presence of floor or ceiling effects. They are considered to be present when more than 15% of respondents achieved the lowest or highest possible score. Thus, the responsiveness is limited because changes cannot be measured in these patients nor is it possible to distinguish one from another, which compromises reliability.
\nLimitations in measurements, such as ceiling or floor effects, can usually be avoided by selecting measures that have been demonstrated to provide meaningful information about people who are similar to those being measured. In other words, the target population of each measurement tool must be considered by matching the sample, e.g., patients with the appropriate questionnaire or functional scale.
\nThe Rasch model and the factor analysis constitute two ways of assessing psychometric properties of an instrument and can be, and frequently are, used in functional scales development. These two statistical procedures have the same theoretical model, which is the item response theory. The basic concept behind IRT is that the probability of choosing a response for each item is a function of both the subject’s or patient’s ability and the difficulty level of each item.
\nWhen applying the concepts of IRT to psychometric properties analysis, it is possible to obtain more detailed information about validity, accuracy, and targeting that helps understanding the clinical meaning of a self-report instrument. It goes beyond just looking at the final score of a questionnaire or at cutoff scores. This closer look at outcome measures like functional scales adds information to those obtained by traditional statistical tests, e.g., Cronbach alpha or ICC. IRT not only improves the methodological quality when elaborating new instruments but gives clearly insights into effects of intervention as well, whether comparing groups or the subject longitudinally.
\nRasch analysis can be applied to examine instruments or assessment scales applicable in wide spectrum of disciplines, including studies in health area, education, marketing, economy, and social sciences. In the majority of evaluations, a well-defined group is selected to answer a series of predefined items. The Rasch model offers a mathematical theoretical reference by which researches that elaborate instruments are able to create comparable measures. The main point behind this model is the concept of unidimensionality, which can be summarized by the idea that useful clinical measures involve the analysis of only one human attribute at the time. In other words, it implies that the instrument measures a single latent ability. Taking a self-report questionnaire as an example, this would mean the items are organized according to their difficulty level and are placed in a single linear hierarchic scale.
\nThe Rasch model transforms ordinal scales into interval measures. This process allows us to calibrate item difficulty and subject’s ability in a same linear
where
If all items meet this probabilistic expectation, it is possible to state that the questionnaire, as a whole, assesses an unidimensional construct. This probabilistic framework constitutes the basis of Rasch model and thereby makes it possible to organize items by their difficulty level as well as by the patients’ ability level, both based on the observed answering pattern.
\nQuestionnaires should be responsive to changes in the status of the patient across the spectrum of ability. Another benefit of IRT is that it provides the amount of information that each item contributes at varying levels of ability. Easy items should provide information among low-ability levels examinees, and conversely, hard items that describe difficult tasks give information among high-ability examinees. The questionnaire final score is, therefore, the sum of all these information collected by each item, and the accuracy of it is directly proportional to the amount of information provided. The target of an evaluative instrument is to provide information across all ability ranges. Therefore, such an appropriate evaluative questionnaire should contain items that assess an individual’s ability to perform activities that span from easy to more challenging ones.
\nThe results of an item characteristic curve are valuable only when the following requirements are met:
Unidimensionality
The questionnaire measures a single latent trait.
Local independence
The answer for each item is independent from another item.
No time constraints
Should be no time limit or restriction when answering the test.
No guessing as an answer
A correct answer may not due to guessing but reflect the person’s ability.
This implies that only one latent ability accounts for the individual’s response for each of the items contained on the instrument, which is exactly the unidimensionality mentioned throughout this section. Both factor analysis and the Rasch model can ascertain this aspect of construct validity. Those items that did not fit to the model should be revised or eliminated accordingly with scale’s goals.
\nMeasures should be chosen based on whether they have been designed for and have been used with people similar to the people to be measured. For example, to assess an elite athlete’s functionality after an ankle sprain, sport subscale of the foot and ankle ability measure questionnaire should provide more clinical useful information than the whole lower extremity functional scale (LEFS). This is not because one instrument is better than the other is, but because it is a better instrument selection to the target population or the right patient.
\nThe next section shows four self-report questionnaires that are currently available for measuring ankle-related functionality. Some systematic reviews report that these instruments have very good psychometric properties and are quite useful for clinical scenarios as well as for research contexts. A brief overview for each of them is provided. For full information, we suggest to read the original studies about their development.
\nThe LEFS is a measure of activity limitation developed for musculoskeletal conditions of the lower extremity. On this scale, participants rate the difficulty in performing 20 activities of the lower extremity on a 5-point Likert scale, rating grade 0, meaning “extreme difficulty or unable to perform activity,” to grade 4, meaning “no difficulty”. The responses are summed to give a score ranging from 0 to 80, with 0 indicating high functional limitation and 80 indicating low functional restriction. LEFS was tested in a heterogeneous population with different lower limb conditions and was found to have high internal consistency (.96) and high test-retest reliability (
The FAAM is composed of two subscales named activities of daily living (ADL) and sports subscale, respectively. ADL subscale has 21 items and the sports subscale 8 items. Each item is scored on a 5-point Likert scale anchored by 4 (no difficulty at all) and 0 (unable to do). Item score totals, which range from 0 to 84 for the ADL subscale and from 0 to 32 for the sports subscale, are transformed to percentage scores. A higher score represents a higher level of function for each subscale.
\nThe FAOS is a 42-item questionnaire divided into 5 subscales: “pain” (9 items), “other symptoms” (7 items), “activities of daily living” (17 items), “sport and recreation function” (5 items), and “foot- and ankle-related quality of life” (4 items). Each question can be scored on a 5-point Likert scale (from zero to four) and each of the five subscale scores is calculated as the sum of the items included. Raw scores are then transformed to a 0 to 100, worst to best score.
\nThe CAIT is a nine-item questionnaire designed to be a discriminative instrument of chronic ankle instability. The questionnaire is structured so that the feeling of instability is reported for different types of activities such as running, walking, hopping, and descending stairs. The nine items generate a total score from 0 to 30 for each foot, in which 0 is the worst possible score, meaning severe instability, and 30 is the best possible score, meaning normal stability. The CAIT is a reliable (ICC 0.96) instrument that can discriminate stable from unstable ankles and measure the severity of functional ankle instability.
\nTable 1 summarizes the main psychometric properties of each instruments reported above.
\n\n\n | \n | \n\n | \n\n | \n\n | \n
---|---|---|---|---|
\n | \n92% of variance explained at baseline Concurrent validity r = .80 and .87, at short and medium term follow up, respectively (correlation with Olerud-Molander ankle score) | \nExperts and patients were involved in item generation and reduction | \nItem selection and reduction by patients (n = 213) Experts: not involved | \nCAIT and LEFS (α = .50, P < .01) and VAS (α.76, P < .01) Construct validity and internal reliability were acceptable (α = .83; point measure correlation for all items, >0.5; item reliability index, .99) | \n
\n | \nNo information | \nADL subscale: ICC = .89; SEM = 2,1 points Sport subscale: ICC = .87; SEM = 4,5 points | \nSubscale pain, rs = .96; subscale symptoms, rs = .89; subscale ADL, rs = .85; subscale sports, rs = .92; subscale quality of life, rs = .92 | \nICC, 0,96 | \n
\n | \nα = .92 at base line; .94 short term; .90 long term. | \nCronbach alpha for ADL subscale, α = .96 in stable group (n = 79); in changed group, α = .98 (n = 164) Cronbach alpha for sport subscale from a combined sample, α = .98 | \nSubscale pain, α = .94; subscale symptoms, α = .88; subscale ADL, α = .97; subscale sports, α = .94; subscale “quality of life,” α = .92 | \nThe threshold CAIT score was 27.5 (Youden index, 68.1); sensitivity was 82.9% and specificity was 74.7%. | \n
\n | \nGuyatt = 1.99 AUC ROC = 0.79 (95% CI = 0.70-0.88) | \nMDC ADL subscale, 5.7 MDC Sport subscale, 12.3 | \nNo information | \nNo information | \n
Main psychometric properties of ankle-related self-report measures.
\n
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