Patrick Arbuthnot

University of the WitwatersrandSouth Africa

Patrick Arbuthnot is Personal Professor and Director of the Antiviral Gene Therapy Research Unit of the University of the Witwatersrand (Wits) in South Africa. After graduating with a medical degree from Wits, Patrick Arbuthnot completed a PhD in 1992. From 1993 to 1994, he worked as a post-doctoral researcher at Necker Hospital in Paris, and investigated the development of gene therapy for treating liver cancer and hepatitis B virus (HBV) infection. On returning to South Africa, Patrick Arbuthnot established the Antiviral Gene Therapy Research Unit. This unit is now a Centre of Excellence of the African Network for Drug and Diagnostic Innovation (ANDI). The unit has a research interest in HBV infection, liver cancer, HIV-1 infection and developing new methods of treating these diseases.

1books edited

Latest work with IntechOpen by Patrick Arbuthnot

The articles that appear in Antiviral Drugs - Aspects of Clinical Use and Recent Advances cover several topics that reflect the varied mechanisms of viral disease pathogenesis and treatment. Clinical management and new developments in the treatment of virus-related diseases are the two main sections of the book. The first part reviews the treatment of hepatitis C virus infection, the management of virus-related acute retinal necrosis, the use of leflunomide therapy in renal transplant patients, and mathematical modeling of HIV-1 treatment responses. Basic research topics are dealt with in the second half of the book. New developments in the treatment of the influenza virus, the use of animal models for HIV-1 drug development, the use of single chain camelid antibodies against negative strand RNA viruses, countering norovirus infection, and the use of plant extracts to treat herpes simplex virus infection are described. The content of the book is not intended to be comprehensive, but aims to provide the reader with insights into selected aspects of established and new viral therapies.

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