Maurizio Balestrino was born in Genoa, Italy, the birthplace of Christopher Columbus and of the blue jeans. He received there the Degree in Medicine and the Diploma of Specialist in Neurology. In 1983-1986 he was Research Associate in the Department of Physiology at Duke University, where he started an interest in ischemic brain damage. Back in Italy he has always combined clinical responsibilities as a neurologist and experimental research in brain anoxia or ischemia. He is currently Senior Researcher in the Stroke Unit of the University of Genoa, where he also directs the Laboratory of Experimental Neurophysiology. He has been partner or coordinator in national and international research projects aiming at bridging the gap between experimental research and clinical therapy.