Radu Albulescu

By Simona O. Dima, Cristiana Tanase, Radu Albulescu, Anca Botezatu and Irinel Popescu

Part of the book: Pancreatic Cancer

By Cristiana Pistol Tanase, Ana-Maria Enciu, Maria Linda Cruceru, Laura Georgiana Necula, Ana Iulia Neagu, Bogdan Calenic and Radu Albulescu

Part of the book: Pancreatic Cancer

By Radu Albulescu, Adrian Claudiu Popa, Elena Codrici, Daniela Ionela Popescu, Simona Mihai and Cristiana Tanase

Part of the book: Pancreatic Cancer

By Radu Albulescu, Andrei Jose Petrescu, Mirela Sarbu, Alice Grigore, Raluca Ica, Cristian V. A. Munteanu, Adrian Albulescu, Ioana V. Militaru, Alina-Diana Zamfir, Stefana Petrescu and Cristiana Tanase

Cancer is considered as the second cause of morbidity and also mortality, after cardiovascular diseases. Despite the immense progress in efficacious biomarkers made in the present time, there are very few of them that can timely detect cancers or that can predict treatment outcomes or stratify patients according to their response to the treatment. Among other modern instruments involved in the research of this disease, proteomics emerged strongly, since it analyzes the “molecular effectors.” Although it has some setbacks (like the lack of amplification of the signal), it is however one of the best means of investigating the presence and causes and predicting the evolution patterns of the disease. This chapter describes briefly pre-analytical (pre-MS steps), the main concepts, and the MS equipment used for such applications, followed by the presentation of several proteomic applications in melanoma, glioblastoma, pancreatic cancer, and colon cancer.

Part of the book: Proteomics Technologies and Applications