Part of the book: Hysterectomy
Part of the book: Enhancing Success of Assisted Reproduction
This chapter presents new views on thrombogenic risk factors, thrombophilia, and thrombotic state of readiness preceding the thrombus formation. The modern methods of laboratory diagnostics of thrombotic state of readiness are considered to initiate thromboprophylaxis in patients irrespective of the presence of thrombophilia, as well as certain thrombogenic risk factors.
Part of the book: Anticoagulation Therapy
This chapter presents the results of the prospective cohort study of 500 females with factor V Leiden, FVL, 1691 GA genotype, during 2008–2015. The association between FVL (regardless of its laboratory phenotype—factor Va resistance to activated protein C, APC resistance) and the development of VTEC (both outside of and during pregnancy) and gestational complications such as preeclampsia, fetal growth restriction, and miscarriage has been established. Additionally, the leading role of APC resistance degree in the clinical manifestation of FVL 1691 GA genotype as thrombotic events and pregnancy complications has been proved. Based on the data obtained, advanced approaches for the stratification of pregnant women into risk groups for the development of venous thromboembolic complications and pregnancy complications at different gestational ages adjusted for APC resistance degree are proposed. The found patterns can be useful in assessing the need for heparin prophylaxis during pregnancy from the standpoint of personalized medicine.
Part of the book: Pregnancy and Birth Outcomes