Mani T. Valarmathi

The University of Alabama at Birmingham

Dr. Mani T. Valarmathi received his B.Sc. in Chemistry, M.B.B.S. in Medicine & Surgery and M.D. in Pathology from the University of Madras, Madras, India; as well as Ph.D. in Medical Biotechnology from All-India Institute of Medical Sciences (AIIMS), New Delhi, India. He was appointed as an Assistant Professor in the Department of Pathology in SRMC & RI (Deemed University), affiliated with Harvard Medical International, Madras, India. He received a Visiting Scientist Fellowship from the National Institute of Health (NIH) and spent two years with Dr. Ira Pastan in the Laboratory of Molecular Biology (LMB). He joined the Department of Comparative Biosciences at the University of Illinois at Urbana-Champaign (UIUC) in 2013 after working as a Research Assistant Professor at the University of South Carolina (USC) in Columbia, South Carolina. In UIUC, he conducted his cardiovascular physiology teaching and cardiovascular research in College of Medicine, College of Veterinary Medicine and the Beckman Institute for Advanced Science and Technology. His past research experience includes human cancer genetics. He is serving as a member of various prestigious national and international scientific societies and organizations such as ISSCR, TERMIS, AACR, ASIP, ACS, ESC, ISHR, ASGCT and AHA. Currently, his research mainly focuses on creating functional vascularized tissue-engineered constructs for cardiovascular repair and regeneration.

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Latest work with IntechOpen by Mani T. Valarmathi

Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

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