The Joint Center at Dalin Tzu Chi General Hospital in Taiwan has been studying knee osteoarthritis for more than a decade. According to our clinical observation and researches, we found the cause of knee osteoarthritis and develop an arthroscopic surgery, called Arthroscopic Cartilage Regeneration Facilitating Procedure(ACRFP), to eradicate the cause and factors of knee osteoarthritis and to create a healthy knee environment as well. We also provide a post-operative cartilage regeneration therapy helping reverse the natural course of disease. This comprehensive treatment plan is named \Knee Health Promotion Option\. During recent years, more than 500 patients receive KHPO in our center for each year. We routinely follow up their prognosis. The latest result of 3-year follow-up survey shows over 90% of patients have been satisfied with the improvement in knee pain and function. Also, more than 80% of patients\' knee x-rays indicate the statistically significant improvement in knee alignment and joint space width in comparison of pre-operative x-rays. Primary reference publications are listed here: Wang, H. S., Kuo, P. Y., Yang, C. C., & Lyu, S. R. (2011). Matrix metalloprotease-3 expression in medial plica and pannus-like tissue in knees from patients with medial compartment osteoarthritis. Histopathology, 58(4), 593-600. Shaw-Ruey Lyu, Jui-Kun Chiang, Chih-En Tseng, Medial plica in patients with knee osteoarthritis: a histomorphological study, Knee Surg Sports Traumatol Arthroscopy, Published online: 14 October 2009 Shaw-Ruey Lyu, Arthroscopic medial release for medial compartment osteoarthritis of the knee, J Bone Joint Surg Br, September, 2008, Vol 90-B, issue 9, Pages 1186-1192 Shaw-Ruey Lyu, Relationship of medial plica and medial femoral condyle during flexion. Clinical Biomechanics, 2007, Volume 22, Issue 9, Pages 1013-1016 Shaw-Ruey Lyu, Jeh-En Tzeng, Chia-Yuan Kuo, Ai-Ru Jian, De-Shin Liu, Mechanical strength of mediopatellar plica - The influence of its fiber content. Clinical Biomechanics, Volume 21, Issue 8, October 2006, Pages 860-863 Lyu SR, Hsu CC, Medial plicae and degeneration of the medial femoral condyle. Arthroscopy. 2006 Jan;22(1):17-26.