Sabine Wislet

University of LiègeBelgium

Dr. Sabine Wislet-Gendebien obtained her PhD from the Center of Cellular and Molecular Neurobiology at the University of Liège under the supervision of Dr. Bernard Rogister and Dr. Gustave Moonen. She completed her postdoctoral training at the Center for Research in Neurodegenerative Disorders directed by Professor St George-Hyslop, in Dr. Anurag Tandon’s laboratory, at the university of Toronto. She is currently a Senior Scientist at the GIGA Neurosciences and an Assistant Professor in the Department of Biomedical and Preclinical Sciences, at the University of Liège. Dr Wislet-Gendebien research focuses on cell replacement therapy in neurological disorders, using adult bone marrow stromal cells.

3books edited

2chapters authored

Latest work with IntechOpen by Sabine Wislet

Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

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