Ana Colette Maurício

University of Porto

Ana Colette Maurício has a degree in Veterinary Medicine, a Ph.D. in Veterinary Sciences from the Faculty of Veterinary Medicine (FMV) – University of Lisbon (UTL). Presently she is the Associate Professor with Habilitation in Veterinary Sciences at Abel Salazar Institute of Biomedical Sciences from University of Porto (ICBAS-UP), Head of the Veterinary Clinics Department, Director of the Veterinary Sciences Doctoral Program, Vice-President of the Pedagogic Council at ICBAS-UP, and Member of the Ethics Commission for Health Sciences from University of Porto. She is the Scientific Coordinator of the Regenerative Medicine and Experimental Surgery research sub-unit from Animal Science Studies Centre (CECA), Institute of Sciences, Technologies and Agro Environment from University of Porto (ICETA). She is one of the founding shareholders of Biosckin, Molecular and Cell Therapies, S.A, a private bank of umbilical cord blood and umbilical cord matrix stem cells authorized by the national authorities, also working in the development of new cell therapies and medical devices. She created a multidisciplinary team that has a crucial role in the development of biomaterials and cellular therapies, allowing a close share of knowledge between biomaterials design, development of cellular systems, and clinicians’ needs. She is the supervisor of several post-graduate students, co-author of a large number of scientific articles and book chapters. She has been a principal researcher of several national and international scientific projects.

2books edited

9chapters authored

Latest work with IntechOpen by Ana Colette Maurício

Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.

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