Part of the book: Stem Cells in Clinic and Research
Numerous novel spectroscopy techniques have been developed to perform detection and characterization at molecular level. Nevertheless, the resolution of spectroscopy remains to be the bottleneck, and local electric field is involved to solve this issue. Localized surface plasmon resonance (LSPR) occurred at the surface of noble metal nanoparticles is a major source of enhanced local electric field which provide notable enhancement factor of spectroscopy applying fluorescence and the Raman scattering. In this chapter, we will firstly present the physics of localized surface plasmon resonance to gain a basic understanding. Several current techniques to prepare a wide variety of nanoparticles and localized surface plasmon resonance detector are subsequently introduced. We further illustrate two examples taking advantage of experiments and modeling to elaborate the effect of localized surface plasmon resonance on spectroscopy under different circumstances. The combination of experimental and theoretical approaches elucidates the influence of each factor and promotes the design of localized surface plasmon resonance detector used in spectroscopy.