Chapters authored
Skeletal Regeneration by Mesenchymal Stem Cells: What Else?
Part of the book: Regenerative Medicine and Tissue Engineering
Brucellosis – Granulomatous Spine Infection
Brucellosis mainly affects the musculoskeletal system, with the spine as the most common location. Diagnosis is based on clinical symptoms, but in some cases, they may be lacking. Laboratory diagnosis is mainly made on the combination of high erythrocyte sedimentation rate (ESR) together with high levels of C-reactive protein (CRP) and leukocytosis. Blood culture is a very cost-effective investigation; plain radiographs may be useful, but magnetic resonance images (MRI) with gadolinium enhancement is the choice for diagnosing osteoarticular and spinal complications of human brucellosis. MRI diffusion-weighted imaging fast sequence is the most sensitive for differentiating acute and chronic forms of spondylodiscitis. The basis for treatment is usually the medical management. The indications for surgical treatment (endoscopy or open) are when: no microorganism has been isolated, spinal cord or dural compression is seen in MRI, or there's spinal instability or severe deformity. Open surgery is the standard: the anterior approach allows for anterior disc and bone debridement. If there is an epidural abscess or posterior elements are involved it's indicated as a posterior approach. To prevent relapses and reduce the rate of sequelae, it's necessary to have an appropriate duration of antimicrobial therapy and a timely indication to perform surgery.
Part of the book: Updates on Brucellosis