Paola Tonino

Dr. Paola Tonino holds a Doctoral Degree in Cell Biology from the Universidad Central de Venezuela (Caracas, 1999), where she studied tumor angiogenesis in different regions of human gastrointestinal carcinomas. She currently works as an Associate Professor at the Universidad Central de Venezuela and has 15 years of experience teaching at undergraduate and graduate level. Her post doctoral work in the United States includes the study of the structure and function of myosin smooth muscle and nebulin skeletal muscle in a knockout mouse model. She has published her work in several peer reviewed journals and given oral and poster presentations at national and international conferences. In addition she has authored Venezuelan grants and participated in grants from the National Institute of Health. She was also awarded for the most outstanding programs in Venezuela in the past 16 years. Her fields of special expertise include cancer biology and angiogenic factors as biomarkers of diagnosis and prognosis in gastrointestinal carcinomas.

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Latest work with IntechOpen by Paola Tonino

This book is a comprehensive overview of invited contributions on Helicobacter pylori infection in gastritis and gastric carcinogenesis. The first part of the book covers topics related to the pathophysiology of gastric mucosal defense system and gastritis including the gastroprotective function of the mucus, the capsaicin-sensitive afferent nerves and the oxidative stress pathway involved in inflammation, apoptosis and autophagy in H. pylori related gastritis. The next chapters deal with molecular pathogenesis and treatment, which consider the role of neuroendocrine cells in gastric disease, DNA methylation in H. pylori infection, the role of antioxidants and phytotherapy in gastric disease. The final part presents the effects of cancer risk factors associated with H. pylori infection. These chapters discuss the serum pepsinogen test, K-ras mutations, cell kinetics, and H. pylori lipopolysaccharide, as well as the roles of several bacterial genes (cagA, cagT, vacA and dupA) as virulence factors in gastric cancer, and the gastrokine-1 protein in cancer progression.

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