Chapters authored
Mice as an Experimental Model to Understand the Pathobiology of Diseases
Murine models are widely used in scientific research because they share many genetic similarities with humans, making them a valuable tool for studying various diseases. C57BL/6 is an experimental mouse model to study the demyelination and inflammation aetiology of multiple sclerosis (MS). Intracranial inoculation of neurotropic murine β-coronavirus strain of mouse hepatitis virus in C57BL/6 mice induces demyelination with or without axonal loss, providing many insights regarding the mechanism of MS as well as SARS-CoV-2-mediated pulmonary and neuropathology in humans. By selectively using knockout mice in the wild-type C57BL/6 background, researchers can gain insights into the immunomodulatory nexus and can identify pathways involved in immune regulation which further can be efficiently studied with CD4−/−, CD40−/−, and CD40L−/− mice. In addition, C57BL/6 mice can also be used to generate syngeneic mouse models to investigate the aetiology and mechanism of various cancers, including ovarian cancer. Similarly, along with C57BL/6 mice, different immunocompromised mice models, such as nude mice, SCID mice, and NOD/SCID mice, can be used to study the aetiology, host-tumour interaction, function of the microenvironment, and tumour heterogeneity in tumour metastasis.
Part of the book: Rodents and Their Role in Ecology, Medicine and Agriculture