I have been an investigator in the field of immunology for the past 25 years, which includes 3 years of post-doctoral research work in USA at the National Institute of Health in Bethesda, MD and the Hospital for Joint Diseases at New York University, NY. Currently, I hold joint appointments as Head of the Cellular and Molecular Allergology Unit at the San Raffaele Scientific Institute and as adjunct Professor of Molecular Allergy and Clinical Immunology in the Faculty of Medicine at Vita-Salute University, Milan, Italy. I made scientific publications on international peer-reviewed Journals (see Publications) in the field of immunology, primarily in the area of allergy, autoimmunity and AIDS immunotherapy. I am serving on numerous grant review committees, including the National AIDS program funded by the Italian ministry of health and education, the Nederland Asthma Foundation and the European Community. I am the Scientific Director of ALLTOX (www.alltox.it), which is a commercial spin-off of the San Raffaele science park, for the in vitro evaluation, testing and prediction of allergenicity of chemicals and xenobiotics. I serve as a supervisor for PhD students and post-doctoral fellows specializing in several fields of allergy, immunology and immunotherapy. I am a member of the Editorial Board of Clinical Immunology and an active reviewer in Clinical and Experimental Allergy, Journal of Allergy and European Journal of immunology, among others. I am responsible for supervision of multicentric clinical trials evaluating safety and efficacy of immunotherapy in allergic individuals. I am also responsible for research projects on the role of dendritic cells in the immune response to allergens and on the role of T lymphocytes in lower respiratory tract of asthmatic individuals.