Alexandra Travesre-Glehen
Hospices Civils de Lyon, Institut de pathologie multisite, Hôpital Lyon Sud, Lyon, France Centre International de Recherche en Infectiologie (CIRI), Université Claude Bernard Lyon-1, Lyon, France
Mediastinal gray zone lymphoma is now recognized as a distinct entity in the newly updated classification of hematolymphoid malignancies. In recent years, several clinicopathological and molecular studies have helped to clarify the spectrum of this entity, which is intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-cell Lymphoma. The mediastinal location remains an important feature of the disease and it needs to be cautious to do this diagnosis in extramediastinal location. In addition, cases with EBV association should be better classified in polymorphic EBV+ B-cell lymphomas until a better understanding of this entity. As in PMBCL and CHL, MGZ exhibits a high rate of immune escape with CIITA break and PDL1/PDL2 abnormalities.
Part of the book: Molecular Diagnostics of Cancer