Peter Mikuš

Peter Mikus (PM) received his M.Sc. in Analytical Chemistry in 1995 from the Faculty of Natural Sciences Comenius University in Bratislava, Slovak Republic. He received his Ph.D. in Analytical Chemistry from the same Faculty in 2002 under the supervision of Prof. Dr. Dusan Kaniansky, an excellent analyst and expert in the field of instrumental development of capillary electomigration techniques. During his Ph.D. study, in 1997, PM joined academic and research center, namely Consiglio Nazionale delle Ricerche, Istituto di Cromatografia in Rome, Italy. Here, he made research for a period of three months under the supervision of Prof. Dr. Salvatore Fanali, an expert in the field of advanced methodology and application of chiral capillary electomigration methods. From 2002 he worked at the Faculty of Pharmacy Comenius University as a teacher and research scientist. PM received his Assoc. Prof. qualification in Pharmaceutical Chemistry from the Faculty of Pharmacy Comenius University in 2007. Currently, he is Assistant Professor, the Head of the Department of Pharmaceutical Analysis and Nuclear Pharmacy, Vice-dean for Foreign Relations and Development of the Faculty, and Departmental Erasmus Coordinator at the Faculty of Pharmacy Comenius University. Research interests of PM include development of new progressive (chiral) capillary electrophoresis separation methods for the advanced pharmaceutical and biomedical analyses of drugs, their (bio)degradation products, and biomarkers. Within this field it is mainly (i) implementation and testing of new (chiral) buffer additives in the ITP and CZE systems (i.e. advanced separation mechanisms, such as countercurrent and carrier selector systems), (ii) proposals of the 2D capillary electrophoresis methods for the ultratrace analytes present in the multicomponent matrices (i.e. advanced sample preparation, such as on-line sample concentration and clean-up), and (iii) study of analytical possibilities of the hyphenated electrophoretic and detection techniques (i.e. advanced detection stage, such as spectral DAD, LIF, MS: QQQ, Q-TOF for the decreasing of the detection limits and/or structural identification of the known as well as unknown analytes). Within his current research, supported by and carried out in the Excellence Center of Pharmacy at the Faculty of Pharmacy Comenius University, are besides the advanced electrophoretic methods also advanced chromatographic ones (HPLC/2D HPLC-Q-TOF/QQQ). These are developed for the current pharmaceutical and biomedical research program of the Faculty of Pharmacy Comenius University and cooperating institutions.

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The scientific monograph by the author Peter Mikus entitled "Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis" provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The advances in the chiral electrophoresis analytical approaches are divided and theoretically described in three sections involving (i) advanced chiral separations for the optimization of chiral resolution (separation mechanisms; electrophoresis techniques in capillary and microchip format; electrophoretic modes such as ITP, CZE/EKC, CEC; chiral additives / pseudophases / phases), (ii) advanced sample preparation for the on-line preconcentration, sample clean-up and analyte derivatization (implementation of electrophoretic effects such as stacking; non-electrophoretic effects such as SPE, chromatography, dialysis; combinations of these effects; multidimensional CE systems; instrumental schemes), (iii) advanced combinations of detection and electrophoresis for the optimization in qualitative and quantitative evaluation (the most important universal as well as selective detection approaches such as absorption and fluorescence spectrophotometry, electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real analytical potential (benefits and limitations) of these advanced analytical approaches is emphasized by selected performance parameters of the methods and illustrated by many current practical applications including chiral analyses of drugs, their (bio)degradation products and biomarkers in pharmaceutical and biological matrices. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.

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